{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/30417"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/30417","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses","abstract":"Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. <italic>Bordetella</italic> species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the <italic>bps</italic> locus is required for biofilm formation and production of the <italic>Bordetella</italic> polysaccharide (Bps), a major constituent of <italic>Bordetella</italic> biofilms.","abstract_html":"Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. &lt;italic&gt;Bordetella&lt;/italic&gt; species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the &lt;italic&gt;bps&lt;/italic&gt; locus is required for biofilm formation and production of the &lt;italic&gt;Bordetella&lt;/italic&gt; polysaccharide (Bps), a major constituent of &lt;italic&gt;Bordetella&lt;/italic&gt; biofilms.","abstract_has_math":false,"creators":["Love, Cheraton Fabrice"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-27T22:01:14Z","subjects":["antimicrobial peptides"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/30417","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Love, Cheraton Fabrice"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-02-16T21:42:30Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-02-16T21:42:30Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["antimicrobial peptides"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/30417"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. <italic>Bordetella</italic> species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the <italic>bps</italic> locus is required for biofilm formation and production of the <italic>Bordetella</italic> polysaccharide (Bps), a major constituent of <italic>Bordetella</italic> biofilms."]},{"key":"dc:title","label":"Title","values":["The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses"]}]}],"canonical_facts":{"dc:creator":["Love, Cheraton Fabrice"],"dc:date.accessioned":["2011-02-16T21:42:30Z"],"dc:date.available":["2011-02-16T21:42:30Z"],"dc:date.issued":["2010"],"dc:description.abstract":["Bacteria face many challenges during infection of the host. Initiation of infection requires attachment to host surfaces. <italic>Bordetella</italic> species possess several virulence factors that mediate binding to the host such as filamentous hemagglutinin and pertactin. A crucial component of successful colonization is evasion of host defenses. Biofilms have been proposed to promote bacterial persistence by suppressing the effectiveness of host responses. A hallmark of mature biofilms is the production of a matrix composed of extracellular polymers including proteins, DNA and polysaccharides. We have shown that the <italic>bps</italic> locus is required for biofilm formation and production of the <italic>Bordetella</italic> polysaccharide (Bps), a major constituent of <italic>Bordetella</italic> biofilms."],"dc:identifier.uri":["http://hdl.handle.net/10339/30417"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["antimicrobial peptides"],"dc:title":["The Role of Bps Polysaccharide in Bordetella Resistance to Host Innate Defenses"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:01:14Z"}