{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/14832"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/14832","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking","abstract":"Conditioned stimuli (CSs) associated with reward object availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking behaviors and may likewise be involved in dietary relapse. These three novel experiments utilized a relapse to food-seeking paradigm to test the effects of intra-accumbal pharmacological manipulations on the reinstatement of responding for a food reinforcer by a CS previously associated with the reward. Rats received intra-accumbal infusions of saline or a selective D1 receptor antagonist, mu-opioid receptor agonist, or the neurotransmitter serotonin prior to cue-evoked reinstatement sessions. Both NAcc D1 receptor antagonism by SCH 23390 and mu-opioid receptor agonism by [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) effectively blunted the reinstatement of reward-directed responding by the CS as compared to infusions of the saline vehicle solution. In contrast, the stimulation of serotonin (5-HT) receptors by 5-HT hydrogen maleate did not affect the relapse to food seeking by the reward-associated cues. Together, these data indicate selective roles for specific NAcc receptor activation in the ability for a reward-paired CS to reinstate natural reward-seeking behaviors. Furthermore, these data suggest that the NAcc is likely involved in the failure to abstain from palatable foods in individuals undergoing dietary restriction.","abstract_html":"Conditioned stimuli (CSs) associated with reward object availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking behaviors and may likewise be involved in dietary relapse. These three novel experiments utilized a relapse to food-seeking paradigm to test the effects of intra-accumbal pharmacological manipulations on the reinstatement of responding for a food reinforcer by a CS previously associated with the reward. Rats received intra-accumbal infusions of saline or a selective D1 receptor antagonist, mu-opioid receptor agonist, or the neurotransmitter serotonin prior to cue-evoked reinstatement sessions. Both NAcc D1 receptor antagonism by SCH 23390 and mu-opioid receptor agonism by [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) effectively blunted the reinstatement of reward-directed responding by the CS as compared to infusions of the saline vehicle solution. In contrast, the stimulation of serotonin (5-HT) receptors by 5-HT hydrogen maleate did not affect the relapse to food seeking by the reward-associated cues. Together, these data indicate selective roles for specific NAcc receptor activation in the ability for a reward-paired CS to reinstate natural reward-seeking behaviors. Furthermore, these data suggest that the NAcc is likely involved in the failure to abstain from palatable foods in individuals undergoing dietary restriction.","abstract_has_math":false,"creators":["Glenn, Elizabeth Anderson"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-05-07T18:38:46Z","date_published":"2010-05-07T18:38:46Z","updated_at":"2026-07-27T22:01:01Z","subjects":["Food-Seeking"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/14832","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Glenn, Elizabeth Anderson"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2010-05-07T18:38:46Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2010-05-07T18:38:46Z"]},{"key":"dc:date.issued","label":"Date","values":["2010-05-07T18:38:46Z"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Food-Seeking"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/14832"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Conditioned stimuli (CSs) associated with reward object availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking behaviors and may likewise be involved in dietary relapse. These three novel experiments utilized a relapse to food-seeking paradigm to test the effects of intra-accumbal pharmacological manipulations on the reinstatement of responding for a food reinforcer by a CS previously associated with the reward. Rats received intra-accumbal infusions of saline or a selective D1 receptor antagonist, mu-opioid receptor agonist, or the neurotransmitter serotonin prior to cue-evoked reinstatement sessions. Both NAcc D1 receptor antagonism by SCH 23390 and mu-opioid receptor agonism by [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) effectively blunted the reinstatement of reward-directed responding by the CS as compared to infusions of the saline vehicle solution. In contrast, the stimulation of serotonin (5-HT) receptors by 5-HT hydrogen maleate did not affect the relapse to food seeking by the reward-associated cues. Together, these data indicate selective roles for specific NAcc receptor activation in the ability for a reward-paired CS to reinstate natural reward-seeking behaviors. Furthermore, these data suggest that the NAcc is likely involved in the failure to abstain from palatable foods in individuals undergoing dietary restriction."]},{"key":"dc:title","label":"Title","values":["A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking"]}]}],"canonical_facts":{"dc:creator":["Glenn, Elizabeth Anderson"],"dc:date.accessioned":["2010-05-07T18:38:46Z"],"dc:date.available":["2010-05-07T18:38:46Z"],"dc:date.issued":["2010-05-07T18:38:46Z"],"dc:description.abstract":["Conditioned stimuli (CSs) associated with reward object availability are known to reinstate reward-seeking behaviors after periods of suppressed responding for a reward. Previous research indicates that the nucleus accumbens (NAcc) is a critical brain region involved in the relapse to drug-seeking behaviors and may likewise be involved in dietary relapse. These three novel experiments utilized a relapse to food-seeking paradigm to test the effects of intra-accumbal pharmacological manipulations on the reinstatement of responding for a food reinforcer by a CS previously associated with the reward. Rats received intra-accumbal infusions of saline or a selective D1 receptor antagonist, mu-opioid receptor agonist, or the neurotransmitter serotonin prior to cue-evoked reinstatement sessions. Both NAcc D1 receptor antagonism by SCH 23390 and mu-opioid receptor agonism by [D-Ala2, N-MePhe4, Gly-ol]-enkephalin (DAMGO) effectively blunted the reinstatement of reward-directed responding by the CS as compared to infusions of the saline vehicle solution. In contrast, the stimulation of serotonin (5-HT) receptors by 5-HT hydrogen maleate did not affect the relapse to food seeking by the reward-associated cues. Together, these data indicate selective roles for specific NAcc receptor activation in the ability for a reward-paired CS to reinstate natural reward-seeking behaviors. Furthermore, these data suggest that the NAcc is likely involved in the failure to abstain from palatable foods in individuals undergoing dietary restriction."],"dc:identifier.uri":["http://hdl.handle.net/10339/14832"],"dc:language.iso":["en_US"],"dc:publisher":["Wake Forest University"],"dc:subject":["Food-Seeking"],"dc:title":["A Comparison of the Manipulations of Dopaminergic, Opioidergic or Serotonergic Systems within the Nucleus Acccumbens on the Cue-Evoked Relapse to Food-Seeking"],"dc:type":["Thesis"]},"updated_at":"2026-07-27T22:01:01Z"}