{"id":{"repo_id":"westminster","oai_identifier":"oai:westminsterresearch.westminster.ac.uk:90750"},"canonical_url":"https://search.dev.ndltd.org/etd/westminster/oai:westminsterresearch.westminster.ac.uk:90750","repository":{"repo_id":"westminster","name":"University of Westminster","base_url":"https://westminsterresearch.westminster.ac.uk/oai2"},"display":{"title":"A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma","abstract":"The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression.","abstract_html":"The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression.","abstract_has_math":false,"creators":["Orchard, G.R."],"institution":"University of Westminster","degree_name":null,"degree_level":"PhD thesis","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-24T06:02:09Z","subjects":["Cutaneous T cell lymphoma (CTCL), malignant melanoma (MM),immunocytochemistry (IMC)"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:westminsterresearch.westminster.ac.uk:90750"],"render_values":[{"text":"oai:westminsterresearch.westminster.ac.uk:90750","href":null,"code":true}]}]},"links":{"outbound_url":"https://doi.org/10.34737/90750","outbound_label":"DOI","outbound_source":"dc:identifier.doi"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Orchard, G.R."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2010"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher","label":"Institution","values":["University of Westminster"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Life Sciences"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Westminster"]},{"key":"dc:relation","label":"Dc Relation","values":["https://westminsterresearch.westminster.ac.uk/item/90750/a-study-of-activation-antigens-involved-in-the-pathologicalmechanisms-and-pathways-of-cutaneous-malignant-disease-withparticular-emphasis-on-cutaneous-t-cell-lymphoma-andmalignant-melanoma"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://westminsterresearch.westminster.ac.uk/item/90750/a-study-of-activation-antigens-involved-in-the-pathologicalmechanisms-and-pathways-of-cutaneous-malignant-disease-withparticular-emphasis-on-cutaneous-t-cell-lymphoma-andmalignant-melanoma"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["PhD thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Cutaneous T cell lymphoma (CTCL), malignant melanoma (MM),immunocytochemistry (IMC)"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["oai:westminsterresearch.westminster.ac.uk:90750"]},{"key":"dc:identifier.doi","label":"DOI","values":["https://doi.org/10.34737/90750"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://westminsterresearch.westminster.ac.uk/download/4536e840c67141f76e10cf6eebcef20557d455a1f4158a3cefb00549f561ce2b/196381/Orchard.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression."]},{"key":"dc:description.abstract","label":"Abstract","values":["The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression."]},{"key":"dc:title","label":"Title","values":["A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma"]}]}],"canonical_facts":{"dc:creator":["Orchard, G.R."],"dc:date":["2010"],"dc:date.issued":["2010"],"dc:description":["The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression."],"dc:description.abstract":["The investigation of dermatological conditions embraces the concept of a clinicopathological correlation. The studies into cutaneous T cell lymphoma (CTCL) and malignant melanoma (MM), presented here involved predominantly immunocytochemical procedures and relate to the investigations into AP-1 protein expression in CTCL and melanocyte activation antigens in MM. Results: Findings indicate that expression of AP-1 proteins differs not only according to type of CTCL but also according to stages of tumour progression. In MM activation antigen expression varies with tumour metastasis. Consideration of the role of techniques in terms of sensitivity and specificity form a pivitol component in the evaluation of tumour antigen expression."],"dc:identifier":["oai:westminsterresearch.westminster.ac.uk:90750"],"dc:identifier.doi":["https://doi.org/10.34737/90750"],"dc:identifier.uri":["https://westminsterresearch.westminster.ac.uk/download/4536e840c67141f76e10cf6eebcef20557d455a1f4158a3cefb00549f561ce2b/196381/Orchard.pdf"],"dc:publisher":["University of Westminster"],"dc:publisher.department":["School of Life Sciences"],"dc:publisher.institution":["University of Westminster"],"dc:relation":["https://westminsterresearch.westminster.ac.uk/item/90750/a-study-of-activation-antigens-involved-in-the-pathologicalmechanisms-and-pathways-of-cutaneous-malignant-disease-withparticular-emphasis-on-cutaneous-t-cell-lymphoma-andmalignant-melanoma"],"dc:relation.isreferencedby":["https://westminsterresearch.westminster.ac.uk/item/90750/a-study-of-activation-antigens-involved-in-the-pathologicalmechanisms-and-pathways-of-cutaneous-malignant-disease-withparticular-emphasis-on-cutaneous-t-cell-lymphoma-andmalignant-melanoma"],"dc:subject":["Cutaneous T cell lymphoma (CTCL), malignant melanoma (MM),immunocytochemistry (IMC)"],"dc:title":["A study of activation antigens involved in the pathologicalmechanisms and pathways of cutaneous malignant disease withparticular emphasis on cutaneous T cell lymphoma andmalignant melanoma"],"dc:type":["Thesis or dissertation"],"dc:type.qualificationlevel":["PhD thesis"]},"updated_at":"2026-07-24T06:02:09Z"}