{"id":{"repo_id":"western-cape","oai_identifier":"oai:uwcscholar.uwc.ac.za:10566/21414"},"canonical_url":"https://search.dev.ndltd.org/etd/western-cape/oai:uwcscholar.uwc.ac.za:10566/21414","repository":{"repo_id":"western-cape","name":"University of the Western Cape","base_url":"https://uwcscholar.uwc.ac.za:8443/server/oai/request"},"display":{"title":"The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review","abstract":"Background: Periodontitis, a multifactorial inflammatory disease affecting the periodontal tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis development. The two main forms, IL-1α and IL-1β, contribute to inflammation, tissue breakdown, and bone loss. Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and periodontitis in persons living in Africa. Objectives: To determine the prevalence of IL-1 gene polymorphism in patients with periodontitis in Africa; determine the distribution of IL-1 gene polymorphisms with regard to geographical location, and demographic profile (age, gender, and ethnicity) and determine the association of combined and specific IL-1 polymorphisms and periodontitis. Method And Analysis: A systematic review was performed using four databases (PubMed, Scopus, Science Direct, EBSCO) were searched for English language case-control studies, reporting on the association between IL-1 and periodontitis in Africa, with no limit to the time until 2023. Covidence® software was used to manage title and abstract screening and full-text review by two reviewers independently, according to the eligibility of the studies, and the discrepancies were resolved by consensus. A random effects model for calculating the odds ratio was conducted using STATA 17 software, which was used for statistical analysis.","abstract_html":"Background: Periodontitis, a multifactorial inflammatory disease affecting the periodontal tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis development. The two main forms, IL-1α and IL-1β, contribute to inflammation, tissue breakdown, and bone loss. Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and periodontitis in persons living in Africa. Objectives: To determine the prevalence of IL-1 gene polymorphism in patients with periodontitis in Africa; determine the distribution of IL-1 gene polymorphisms with regard to geographical location, and demographic profile (age, gender, and ethnicity) and determine the association of combined and specific IL-1 polymorphisms and periodontitis. Method And Analysis: A systematic review was performed using four databases (PubMed, Scopus, Science Direct, EBSCO) were searched for English language case-control studies, reporting on the association between IL-1 and periodontitis in Africa, with no limit to the time until 2023. Covidence® software was used to manage title and abstract screening and full-text review by two reviewers independently, according to the eligibility of the studies, and the discrepancies were resolved by consensus. A random effects model for calculating the odds ratio was conducted using STATA 17 software, which was used for statistical analysis.","abstract_has_math":false,"creators":["Khalid, Reem"],"institution":"University of the Western Cape","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025","date_published":"2025","updated_at":"2026-07-24T06:00:30Z","subjects":["Periodontitis","Chronic Periodontitis","Gene polymorphism","Single nucleotide polymorphisms","Africa"],"languages":[],"rights":[],"rights_urls":["https://uwcscholar.uwc.ac.za/bitstreams/7496de6c-a94c-49af-9678-a6cee8a719bc/download"],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Khalid, Reem"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2025"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of the Western Cape"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://hdl.handle.net/10566/21414"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Periodontitis","Chronic Periodontitis","Gene polymorphism","Single nucleotide polymorphisms","Africa"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["https://uwcscholar.uwc.ac.za/bitstreams/7496de6c-a94c-49af-9678-a6cee8a719bc/download"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://uwcscholar.uwc.ac.za/bitstreams/fad71c95-9c18-401a-9dba-09094bd55b61/download"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Background: Periodontitis, a multifactorial inflammatory disease affecting the periodontal tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis development. The two main forms, IL-1α and IL-1β, contribute to inflammation, tissue breakdown, and bone loss. Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and periodontitis in persons living in Africa. Objectives: To determine the prevalence of IL-1 gene polymorphism in patients with periodontitis in Africa; determine the distribution of IL-1 gene polymorphisms with regard to geographical location, and demographic profile (age, gender, and ethnicity) and determine the association of combined and specific IL-1 polymorphisms and periodontitis. Method And Analysis: A systematic review was performed using four databases (PubMed, Scopus, Science Direct, EBSCO) were searched for English language case-control studies, reporting on the association between IL-1 and periodontitis in Africa, with no limit to the time until 2023. Covidence® software was used to manage title and abstract screening and full-text review by two reviewers independently, according to the eligibility of the studies, and the discrepancies were resolved by consensus. A random effects model for calculating the odds ratio was conducted using STATA 17 software, which was used for statistical analysis."]},{"key":"dc:format.checksum.md5","label":"Dc Format Checksum Md5","values":["386e6ebb79d0f6e34bc6c51a056b5fa4","bb9bdc0b3349e4284e09149f943790b4","fad60af7b6286ad234b293d4c46529d4"]},{"key":"dc:title","label":"Title","values":["The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review"]}]}],"canonical_facts":{"dc:creator":["Khalid, Reem"],"dc:date.issued":["2025"],"dc:description.abstract":["Background: Periodontitis, a multifactorial inflammatory disease affecting the periodontal tissue, is a global oral health concern. While bacterial infections initiate the problem, the body's inflammatory response impacts disease progression. Interleukin-1 (IL-1), a group of molecules known as pro-inflammatory cytokines, has emerged as a critical factor in periodontitis development. The two main forms, IL-1α and IL-1β, contribute to inflammation, tissue breakdown, and bone loss. Research suggests that variations within the genes coding for IL-1 i.e. (polymorphisms) can influence an individual's susceptibility to periodontitis. This systematic review aimed to identify, appraise, and synthesize the best evidence for the association between IL-1 gene polymorphism and periodontitis in persons living in Africa. Objectives: To determine the prevalence of IL-1 gene polymorphism in patients with periodontitis in Africa; determine the distribution of IL-1 gene polymorphisms with regard to geographical location, and demographic profile (age, gender, and ethnicity) and determine the association of combined and specific IL-1 polymorphisms and periodontitis. Method And Analysis: A systematic review was performed using four databases (PubMed, Scopus, Science Direct, EBSCO) were searched for English language case-control studies, reporting on the association between IL-1 and periodontitis in Africa, with no limit to the time until 2023. Covidence® software was used to manage title and abstract screening and full-text review by two reviewers independently, according to the eligibility of the studies, and the discrepancies were resolved by consensus. A random effects model for calculating the odds ratio was conducted using STATA 17 software, which was used for statistical analysis."],"dc:format.checksum.md5":["386e6ebb79d0f6e34bc6c51a056b5fa4","bb9bdc0b3349e4284e09149f943790b4","fad60af7b6286ad234b293d4c46529d4"],"dc:identifier.uri":["https://uwcscholar.uwc.ac.za/bitstreams/fad71c95-9c18-401a-9dba-09094bd55b61/download"],"dc:publisher.institution":["University of the Western Cape"],"dc:relation.isreferencedby":["https://hdl.handle.net/10566/21414"],"dc:rights":["https://uwcscholar.uwc.ac.za/bitstreams/7496de6c-a94c-49af-9678-a6cee8a719bc/download"],"dc:subject":["Periodontitis","Chronic Periodontitis","Gene polymorphism","Single nucleotide polymorphisms","Africa"],"dc:title":["The association between interleukin-1 gene polymorphism and periodontitis in adults in Africa: A systematic review"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T06:00:30Z"}