Wayne State University
Preclinical Evaluation Of Infrared Light Therapy In A Rat Model Of Neonatal Hypoxic-Ischemic Encephalopathy
Abstract
dc:description.abstract<p>Hypoxic events encountered during the perinatal period leading to pathologic decreases in fetal cerebral oxygen availability are detrimental resulting in neonatal hypoxic-ischemic encephalopathy (HIE). This work focused on the characterization of a rat model of neonatal HIE for use in the preclinical evaluation of infrared light therapy (IRL). Consistent with results from previous IRL efficacy studies using a rat model of adult global brain ischemia, IRL treatment attenuated cerebral injury resulting from hypoxia-ischemia in the neonatal rat. Thus, and perhaps most importantly, this work contributes to the development of a potential novel therapeutic approach in the management of brain injuries arising as a result of perinatal asphyxia</p>
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Open Access Dissertation
- Discipline thesis:degree_discipline
- Physiology
- Year dc:date.available
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Reynolds, Christian Andrew
- Contributors dc:contributor
-
- Karin Przyklenk
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Repository record dc:identifier
- https://digitalcommons.wayne.edu/oa_dissertations/1294
- OAI identifier oai:identifier
- oai:digitalcommons.wayne.edu:oa_dissertations-2293