Use Of Focused Ultrasound For Transcranial Sonothrombolysis

<p>Worldwide, stroke is the second most common cause of death. Ischemic stroke remains accountable for the majority of the 20 million devastating stroke events occurring globally each year. Use of transcranial focused ultrasound (FUS) for sonothrombolysis is a new research field for ischemic stroke treatment. If shown to be effective, FUS sonothrombolysis could become a widely available treatment option for the majority of the stroke sufferers that do not qualify or do not have access to current thrombolytic treatment options, such as tPA or neurointerventional methods.</p> <p>The current study was an in vitro transcranial FUS headsystem investigation for the potential treatment of stroke. It was segmented and approached as four progressively building, specific objectives that were developed to collectively answer the investigational question: is focused ultrasound effective for transcranial sonothrombolysis in stroke? </p> <p>(1) Determine the technique feasibility of a FUS system for transcranial sonothrombolysis</p> <p>(2) Perform a parameter optimization for the FUS system for effective sonothrombolysis by varying duty cycle and pulse width settings</p> <p>(3) Characterize the acoustic field produced by the transcranial FUS and determine how it is affected by the skull</p> <p>(4) Determine how sonothrombolysis efficacy and potential clot fragmentation are impacted by varying the FUS intensity</p> <p>The observed, novel in vitro experiences using this new technology are very encouraging. From the four sets of experiments, we have learned that: 1) FUS sonothrombolysis is feasible in an in vitro transcranial flow model; 2) FUS operating parameters such as duty cycle and pulse width can be varied for optimized clot lysis efficacy; 3) transcranial sonothrombolysis efficacy is also dependent on individual skull bone characteristics; and 4) clot lysis depends on the acoustic output power of the FUS system as it relates to effective clot breakdown and potential clot fragments.</p>

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Open Access Dissertation

Discipline thesis:degree_discipline

Biomedical Engineering

Year dc:date.available

2013

Author dc:creator

• Ahadi, Golnaz

Contributors dc:contributor

• Michele J. Grimm
• Thilo Hoelscher

• Focused Ultrasound
• Sonothrombolysis
• Stroke
• Biomedical Engineering and Bioengineering

Repository record dc:identifier

https://digitalcommons.wayne.edu/oa_dissertations/744

OAI identifier oai:identifier

oai:digitalcommons.wayne.edu:oa_dissertations-1743