{"id":{"repo_id":"washington","oai_identifier":"oai:digital.lib.washington.edu:1773/44906"},"canonical_url":"https://search.dev.ndltd.org/etd/washington/oai:digital.lib.washington.edu:1773/44906","repository":{"repo_id":"washington","name":"University of Washington","base_url":"https://digital.lib.washington.edu/server/oai/request"},"display":{"title":"Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study","abstract":"Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine the associations of reported Mg intake, and the interaction of reported Mg intake with single nucleotide polymorphisms (SNPs) related to Mg metabolism and transport, on markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)) among American Indians (AIs). Methods: This cross-sectional study included AI participants (n=1,924) from the Strong Heart Family Study. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. CRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations were used to examine associations of Mg intake, and the interaction of rs3740393 x dietary Mg, on CRP and IL-6. Results: Reported Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP. However, we observed a significant interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. Among participants with the G/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.04 (95% CI: -0.10 to 0.17) mg/l higher. Among participants with the C/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.08 (95% CI: -0.21 to 0.05) mg/l lower, and among participants with the C/C genotype, for every 1 SD higher in log-Mg, log-CRP was 0.19 (95% CI: -0.38 to -0.01) mg/l lower. Conclusion: Among SHFS participants, dietary intake of Mg is not associated with CRP (irrespective of genotype). However, Mg intake is associated with lower IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake with inflammation.","abstract_html":"Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine the associations of reported Mg intake, and the interaction of reported Mg intake with single nucleotide polymorphisms (SNPs) related to Mg metabolism and transport, on markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)) among American Indians (AIs). Methods: This cross-sectional study included AI participants (n=1,924) from the Strong Heart Family Study. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. CRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations were used to examine associations of Mg intake, and the interaction of rs3740393 x dietary Mg, on CRP and IL-6. Results: Reported Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP. However, we observed a significant interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. Among participants with the G/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.04 (95% CI: -0.10 to 0.17) mg/l higher. Among participants with the C/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.08 (95% CI: -0.21 to 0.05) mg/l lower, and among participants with the C/C genotype, for every 1 SD higher in log-Mg, log-CRP was 0.19 (95% CI: -0.38 to -0.01) mg/l lower. Conclusion: Among SHFS participants, dietary intake of Mg is not associated with CRP (irrespective of genotype). However, Mg intake is associated with lower IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake with inflammation.","abstract_has_math":false,"creators":["Rao, Nandana D"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Fretts, Amanda"],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-10-15","date_published":"2019-10-15","updated_at":"2026-07-24T05:57:59Z","subjects":["Epidemiology"],"languages":["en_US"],"rights":["none"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1773/44906","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Fretts, Amanda"]},{"key":"dc:creator","label":"Author","values":["Rao, Nandana D"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2019-10-15T23:01:51Z"]},{"key":"dc:date.issued","label":"Date","values":["2019-10-15"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Epidemiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["none"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["Rao_washington_0250O_20786.pdf"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1773/44906"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (Master's)--University of Washington, 2019"]},{"key":"dc:description.abstract","label":"Abstract","values":["Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine the associations of reported Mg intake, and the interaction of reported Mg intake with single nucleotide polymorphisms (SNPs) related to Mg metabolism and transport, on markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)) among American Indians (AIs). Methods: This cross-sectional study included AI participants (n=1,924) from the Strong Heart Family Study. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. CRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations were used to examine associations of Mg intake, and the interaction of rs3740393 x dietary Mg, on CRP and IL-6. Results: Reported Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP. However, we observed a significant interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. Among participants with the G/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.04 (95% CI: -0.10 to 0.17) mg/l higher. Among participants with the C/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.08 (95% CI: -0.21 to 0.05) mg/l lower, and among participants with the C/C genotype, for every 1 SD higher in log-Mg, log-CRP was 0.19 (95% CI: -0.38 to -0.01) mg/l lower. Conclusion: Among SHFS participants, dietary intake of Mg is not associated with CRP (irrespective of genotype). However, Mg intake is associated with lower IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake with inflammation."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study"]}]}],"canonical_facts":{"dc:contributor.advisor":["Fretts, Amanda"],"dc:creator":["Rao, Nandana D"],"dc:date.accessioned":["2019-10-15T23:01:51Z"],"dc:date.issued":["2019-10-15"],"dc:description":["Thesis (Master's)--University of Washington, 2019"],"dc:description.abstract":["Background: Recent studies suggest that dietary factors, particularly magnesium (Mg) intake, influence systemic inflammation. Whether these associations are modified by genes associated with Mg metabolism and transport is unknown. Objective: To examine the associations of reported Mg intake, and the interaction of reported Mg intake with single nucleotide polymorphisms (SNPs) related to Mg metabolism and transport, on markers of inflammation (i.e., C-reactive protein (CRP) and interleukin 6 (IL-6)) among American Indians (AIs). Methods: This cross-sectional study included AI participants (n=1,924) from the Strong Heart Family Study. Intake of Mg from foods and dietary supplements was ascertained using a 119-item Block food frequency questionnaire. CRP and IL-6 were measured from blood collected after a 12-hour fast, and candidate SNP (rs3740393) was genotyped using MetaboChip. Generalized estimating equations were used to examine associations of Mg intake, and the interaction of rs3740393 x dietary Mg, on CRP and IL-6. Results: Reported Mg intake was not associated with CRP or IL-6. We observed no interaction of reported Mg intake with rs3740393 on CRP. However, we observed a significant interaction (p-interaction=0.018) of reported Mg intake with rs3740393 on IL-6. Among participants with the G/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.04 (95% CI: -0.10 to 0.17) mg/l higher. Among participants with the C/G genotype, for every 1 SD higher in log-Mg, log-CRP was 0.08 (95% CI: -0.21 to 0.05) mg/l lower, and among participants with the C/C genotype, for every 1 SD higher in log-Mg, log-CRP was 0.19 (95% CI: -0.38 to -0.01) mg/l lower. Conclusion: Among SHFS participants, dietary intake of Mg is not associated with CRP (irrespective of genotype). However, Mg intake is associated with lower IL-6 among carriers of the C allele at rs3740393. Future research is necessary to replicate this finding, and to examine other Mg-related genes that may influence associations of Mg intake with inflammation."],"dc:format.mimetype":["application/pdf"],"dc:identifier.other":["Rao_washington_0250O_20786.pdf"],"dc:identifier.uri":["http://hdl.handle.net/1773/44906"],"dc:language.iso":["en_US"],"dc:rights":["none"],"dc:subject":["Epidemiology"],"dc:title":["Dietary Magnesium, C-Reactive Protein and Interleukin-6: The Strong Heart Family Study"],"dc:type":["Thesis"]},"updated_at":"2026-07-24T05:57:59Z"}