{"id":{"repo_id":"washington","oai_identifier":"oai:digital.lib.washington.edu:1773/26176"},"canonical_url":"https://search.dev.ndltd.org/etd/washington/oai:digital.lib.washington.edu:1773/26176","repository":{"repo_id":"washington","name":"University of Washington","base_url":"https://digital.lib.washington.edu/server/oai/request"},"display":{"title":"Tracking buffers of mutation and noise to the genome","abstract":"Phenotypes are buffered from both genetic perturbations and developmental noise; however, the mechanisms by which this buffering occurs and its evolutionary relevance are poorly understood. In this dissertation, a combination of genetic and computational approaches were undertaken to not only identify genetic loci that are buffered from phenotypes but also map genes that provide phenotypic buffering. For example, I found that substrates of Heat shock protein 90 (Hsp90), the best-understood source of buffering, tend to accumulate genetic changes in a manner that affects evolution. Hsp90 is also a proven buffer of developmental noise, so the mechanism by which this ability arises was explored. To expand the number of known developmental noise buffers, innovative methods for genome-wide association were used to map novel regulators. The ability to identify loci that are buffered and provide buffering indicates that the distribution of phenotypes across a population arises through complex interactions between genetic loci, including genes that act as buffers.","abstract_html":"Phenotypes are buffered from both genetic perturbations and developmental noise; however, the mechanisms by which this buffering occurs and its evolutionary relevance are poorly understood. In this dissertation, a combination of genetic and computational approaches were undertaken to not only identify genetic loci that are buffered from phenotypes but also map genes that provide phenotypic buffering. For example, I found that substrates of Heat shock protein 90 (Hsp90), the best-understood source of buffering, tend to accumulate genetic changes in a manner that affects evolution. Hsp90 is also a proven buffer of developmental noise, so the mechanism by which this ability arises was explored. To expand the number of known developmental noise buffers, innovative methods for genome-wide association were used to map novel regulators. The ability to identify loci that are buffered and provide buffering indicates that the distribution of phenotypes across a population arises through complex interactions between genetic loci, including genes that act as buffers.","abstract_has_math":false,"creators":["Lachowiec, Jennifer Anna"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Queitsch, Christine"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-10-13","date_published":"2014-10-13","updated_at":"2026-07-24T05:58:18Z","subjects":["buffering; developmental noise; evolution; genetic variation; robustness"],"languages":["en_US"],"rights":["Copyright is held by the individual authors."],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1773/26176","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Queitsch, Christine"]},{"key":"dc:creator","label":"Author","values":["Lachowiec, Jennifer Anna"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-10-13T16:58:58Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-12-14T17:55:52Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-10-13"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["buffering; developmental noise; evolution; genetic variation; robustness"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["Copyright is held by the individual authors."]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["Lachowiec_washington_0250E_13725.pdf"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1773/26176"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Thesis (Ph.D.)--University of Washington, 2014"]},{"key":"dc:description.abstract","label":"Abstract","values":["Phenotypes are buffered from both genetic perturbations and developmental noise; however, the mechanisms by which this buffering occurs and its evolutionary relevance are poorly understood. In this dissertation, a combination of genetic and computational approaches were undertaken to not only identify genetic loci that are buffered from phenotypes but also map genes that provide phenotypic buffering. For example, I found that substrates of Heat shock protein 90 (Hsp90), the best-understood source of buffering, tend to accumulate genetic changes in a manner that affects evolution. Hsp90 is also a proven buffer of developmental noise, so the mechanism by which this ability arises was explored. To expand the number of known developmental noise buffers, innovative methods for genome-wide association were used to map novel regulators. 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