{"id":{"repo_id":"vu-aus","oai_identifier":"oai:eprints.vu.edu.au:15641"},"canonical_url":"https://search.dev.ndltd.org/etd/vu-aus/oai:eprints.vu.edu.au:15641","repository":{"repo_id":"vu-aus","name":"Victoria University (Australia)","base_url":"https://vuir.vu.edu.au/cgi/oai2"},"display":{"title":"The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans","abstract":"The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise.","abstract_html":"The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise.","abstract_has_math":false,"creators":["Medved, Ivan"],"institution":"Victoria University of Technology","degree_name":"phd","degree_level":"doctoral","degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2005,"date_issued":"2005","date_published":"2005","updated_at":"2026-07-24T06:33:15Z","subjects":["1116 Medical Physiology","School of Sport and Exercise Science","1106 Human Movement and Sports Science"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Medved, Ivan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2005"]},{"key":"dc:date.issued","label":"Date","values":["2005"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["School of Human Movement, Recreation and Performance"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["Victoria University of Technology"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["https://vuir.vu.edu.au/15641/"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["phd"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["1116 Medical Physiology","School of Sport and Exercise Science","1106 Human Movement and Sports Science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://vuir.vu.edu.au/15641/3/MEDVED%20Ivan-thesis_no%20signature.pdf"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise."]},{"key":"dc:format","label":"Dc Format","values":["text"]},{"key":"dc:title","label":"Title","values":["The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans"]}]}],"canonical_facts":{"dc:creator":["Medved, Ivan"],"dc:date":["2005"],"dc:date.issued":["2005"],"dc:description.abstract":["The production of reactive oxygen species in skeletal muscle has been linked with muscle fatigue. Infusion of the antioxidant compound 7V-acetylcysteine (NAC) reduced fatigability in electrically evoked human muscle contractions, but numerous adverse reactions were reported. No studies have investigated NAC infusion effects during voluntary exercise in humans. This thesis investigated whether an NAC infusion protocol that was modified to minimise these adverse reactions, would augment time to fatigue, enhance glutathione availability and enhance potassium (K+) regulation during voluntary fatiguing exercise."],"dc:format":["text"],"dc:identifier.uri":["https://vuir.vu.edu.au/15641/3/MEDVED%20Ivan-thesis_no%20signature.pdf"],"dc:language":["en"],"dc:publisher.department":["School of Human Movement, Recreation and Performance"],"dc:publisher.institution":["Victoria University of Technology"],"dc:relation.isreferencedby":["https://vuir.vu.edu.au/15641/"],"dc:subject":["1116 Medical Physiology","School of Sport and Exercise Science","1106 Human Movement and Sports Science"],"dc:title":["The effects of N-acetylcysteine infusion on performance, glutathione and ion regulation during voluntary exercise in humans"],"dc:type":["Thesis"],"dc:type.qualificationlevel":["doctoral"],"dc:type.qualificationname":["phd"]},"updated_at":"2026-07-24T06:33:15Z"}