{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/9783"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/9783","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Reproduction and Enzyme Detoxification Activities in Mouse Lines Selected for Response to Fescue Toxicosis","abstract":"In previous work, mouse lines were selected for resistance (R) or for susceptibility (S) to fescue toxicosis based upon reductions in post-weaning growth rate caused by an endophyte-infected diet. The first objective of the current experiment was to determine whether long term reproduction of S mice was more severely depressed than that of R mice by the toxic diet. The second objective was to quantify glutathione-S-epoxytransferase (GST) and uridine diphosphate glucuronosyl-transferase (UDPGT) activities in R and S dams form the experiment and to determine whether reproduction during continuous cohabitation and liver detoxification enzyme activities were correlated within line x diet groups. Effects of the toxic diet were detectable within the first litters produced. Reproduction was more seriously influenced by the toxic diet within the S line than within the R line when these measures were compared within four equal time phases. The effects of the toxic diet on reproduction were greatest early in the experiment; by the fourth time phase differences among line x diet groups, with the exception of litter weight, were not significant. Percentage differences in total reproduction were greater between S mice fed the non-toxic diet and S mice fed the toxic diet than those between the R mice fed the non-toxic and toxic diets. Averaged across diets, GST activities were higher in R mice, but UDPGT activities were not significant. Within R line mice, GST was correlated with three reproductive measures, but UDPGT activity was not correlated with reproduction within any line x diet group.","abstract_html":"In previous work, mouse lines were selected for resistance (R) or for susceptibility (S) to fescue toxicosis based upon reductions in post-weaning growth rate caused by an endophyte-infected diet. The first objective of the current experiment was to determine whether long term reproduction of S mice was more severely depressed than that of R mice by the toxic diet. The second objective was to quantify glutathione-S-epoxytransferase (GST) and uridine diphosphate glucuronosyl-transferase (UDPGT) activities in R and S dams form the experiment and to determine whether reproduction during continuous cohabitation and liver detoxification enzyme activities were correlated within line x diet groups. Effects of the toxic diet were detectable within the first litters produced. Reproduction was more seriously influenced by the toxic diet within the S line than within the R line when these measures were compared within four equal time phases. The effects of the toxic diet on reproduction were greatest early in the experiment; by the fourth time phase differences among line x diet groups, with the exception of litter weight, were not significant. Percentage differences in total reproduction were greater between S mice fed the non-toxic diet and S mice fed the toxic diet than those between the R mice fed the non-toxic and toxic diets. Averaged across diets, GST activities were higher in R mice, but UDPGT activities were not significant. Within R line mice, GST was correlated with three reproductive measures, but UDPGT activity was not correlated with reproduction within any line x diet group.","abstract_has_math":false,"creators":["Wagner, Catherine Ann Robertson"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Animal and Poultry Sciences","degree_department":"Animal and Poultry Sciences","school":null,"contributors":[],"advisors":[],"committee_chairs":["Hohenboken, William D."],"committee_members":["Wong, Eric A.","Blodgett, Dennis J."],"year":1998,"date_issued":"1998-09-18","date_published":"1998-09-18","updated_at":"2026-07-22T22:19:47Z","subjects":["Mice","Festuca arundinacea","Reproductive Performance","UDP","Glutathione Transferase"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-051099-130149"],"render_values":[{"text":"etd-051099-130149","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/9783","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Hohenboken, William D."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Wong, Eric A.","Blodgett, Dennis J."]},{"key":"dc:contributor.department","label":"Department","values":["Animal and Poultry Sciences"]},{"key":"dc:creator","label":"Author","values":["Wagner, Catherine Ann Robertson"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2011-08-06T14:48:57Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2011-08-06T14:48:57Z","2000-05-21"]},{"key":"dc:date.issued","label":"Date","values":["1998-09-18"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Animal and Poultry Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mice","Festuca arundinacea","Reproductive Performance","UDP","Glutathione Transferase"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-051099-130149"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/9783"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["In previous work, mouse lines were selected for resistance (R) or for susceptibility (S) to fescue toxicosis based upon reductions in post-weaning growth rate caused by an endophyte-infected diet. The first objective of the current experiment was to determine whether long term reproduction of S mice was more severely depressed than that of R mice by the toxic diet. The second objective was to quantify glutathione-S-epoxytransferase (GST) and uridine diphosphate glucuronosyl-transferase (UDPGT) activities in R and S dams form the experiment and to determine whether reproduction during continuous cohabitation and liver detoxification enzyme activities were correlated within line x diet groups. Effects of the toxic diet were detectable within the first litters produced. Reproduction was more seriously influenced by the toxic diet within the S line than within the R line when these measures were compared within four equal time phases. The effects of the toxic diet on reproduction were greatest early in the experiment; by the fourth time phase differences among line x diet groups, with the exception of litter weight, were not significant. Percentage differences in total reproduction were greater between S mice fed the non-toxic diet and S mice fed the toxic diet than those between the R mice fed the non-toxic and toxic diets. Averaged across diets, GST activities were higher in R mice, but UDPGT activities were not significant. Within R line mice, GST was correlated with three reproductive measures, but UDPGT activity was not correlated with reproduction within any line x diet group."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["ETD"]},{"key":"dc:title","label":"Title","values":["Reproduction and Enzyme Detoxification Activities in Mouse Lines Selected for Response to Fescue Toxicosis"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Hohenboken, William D."],"dc:contributor.committeemember":["Wong, Eric A.","Blodgett, Dennis J."],"dc:contributor.department":["Animal and Poultry Sciences"],"dc:creator":["Wagner, Catherine Ann Robertson"],"dc:date.accessioned":["2011-08-06T14:48:57Z"],"dc:date.available":["2011-08-06T14:48:57Z","2000-05-21"],"dc:date.issued":["1998-09-18"],"dc:description.abstract":["In previous work, mouse lines were selected for resistance (R) or for susceptibility (S) to fescue toxicosis based upon reductions in post-weaning growth rate caused by an endophyte-infected diet. The first objective of the current experiment was to determine whether long term reproduction of S mice was more severely depressed than that of R mice by the toxic diet. The second objective was to quantify glutathione-S-epoxytransferase (GST) and uridine diphosphate glucuronosyl-transferase (UDPGT) activities in R and S dams form the experiment and to determine whether reproduction during continuous cohabitation and liver detoxification enzyme activities were correlated within line x diet groups. Effects of the toxic diet were detectable within the first litters produced. Reproduction was more seriously influenced by the toxic diet within the S line than within the R line when these measures were compared within four equal time phases. The effects of the toxic diet on reproduction were greatest early in the experiment; by the fourth time phase differences among line x diet groups, with the exception of litter weight, were not significant. Percentage differences in total reproduction were greater between S mice fed the non-toxic diet and S mice fed the toxic diet than those between the R mice fed the non-toxic and toxic diets. Averaged across diets, GST activities were higher in R mice, but UDPGT activities were not significant. Within R line mice, GST was correlated with three reproductive measures, but UDPGT activity was not correlated with reproduction within any line x diet group."],"dc:description.degree":["Master of Science"],"dc:format.medium":["ETD"],"dc:identifier.other":["etd-051099-130149"],"dc:identifier.uri":["http://hdl.handle.net/10919/9783"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["Mice","Festuca arundinacea","Reproductive Performance","UDP","Glutathione Transferase"],"dc:title":["Reproduction and Enzyme Detoxification Activities in Mouse Lines Selected for Response to Fescue Toxicosis"],"dc:type":["Thesis"],"thesis:degree_discipline":["Animal and Poultry Sciences"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:19:47Z"}