High-Frequency Irreversible Electroporation (H-FIRE) optimization for the treatment of highly invasive cells beyond the tumor margin

Irreversible electroporation (IRE) is a non-thermal ablation technique that allows for eradication of unresectable tumors in a minimally invasive procedure. While IRE will preferentially kill larger cells over smaller ones, it does not discriminate between cells with larger and small nuclei. Given that one of the hallmarks of cancer cell morphology is larger, more abundant nuclei, our team set out to explore the possibility of preferentially targeting this physical and geometrical characteristic.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Engineering Mechanics

Department dc:contributor.department

Engineering Science and Mechanics

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2016

Author dc:creator

• Latouche, Eduardo L.

Chair dc:contributor.committeechair

• Davalos, Rafael V.

Committee members dc:contributor.committeemember

• Lesko, John J.
• Rossmeisl, John H. Jr.
• Verbridge, Scott

• IRE
• 3D cell culture
• focal ablation
• FEA
• treatment planning
• glioblastoma

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

vt_gsexam:7929

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/81131