{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/76422"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/76422","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Characterization of penicillin production by an immobilized biofilm of Penicillium chrysogenum","abstract":"A stable biofilm of Penicillium chrysogenum in a slab geometry was characterized with respect to penicillin production at various sugar and oxygen concentrations by studies using a novel bench scale bioreactor. The biofilm was submerged in aerated liquid media, mounted vertically in a tube and oriented so that the liquid media and sparged gas bubbles flow uniformly over the two slab faces. The conditions necessary for definite oxygen and sugar limitations were found by operating under various bulk nutrient concentrations. The periodic determination of total biofilm volume (rate of growth) and dry cell weight provided additional information. Definite oxygen mass transfer limitations were found to exist in the biofilm. These limitations could be overcome by increasing the oxygen supply rate to the biofilm.","abstract_html":"A stable biofilm of Penicillium chrysogenum in a slab geometry was characterized with respect to penicillin production at various sugar and oxygen concentrations by studies using a novel bench scale bioreactor. The biofilm was submerged in aerated liquid media, mounted vertically in a tube and oriented so that the liquid media and sparged gas bubbles flow uniformly over the two slab faces. The conditions necessary for definite oxygen and sugar limitations were found by operating under various bulk nutrient concentrations. The periodic determination of total biofilm volume (rate of growth) and dry cell weight provided additional information. Definite oxygen mass transfer limitations were found to exist in the biofilm. These limitations could be overcome by increasing the oxygen supply rate to the biofilm.","abstract_has_math":false,"creators":["Daly, Mary Margaret"],"institution":"Virginia Polytechnic Institute and State University","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Chemical Engineering","degree_department":"Chemical Engineering","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1984,"date_issued":"1984","date_published":"1984","updated_at":"2026-07-22T22:19:16Z","subjects":[],"languages":["en_US"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10919/76422","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Chemical Engineering"]},{"key":"dc:creator","label":"Author","values":["Daly, Mary Margaret"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2017-03-10T21:43:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2017-03-10T21:43:42Z"]},{"key":"dc:date.issued","label":"Date","values":["1984"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Polytechnic Institute and State University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/76422"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A stable biofilm of Penicillium chrysogenum in a slab geometry was characterized with respect to penicillin production at various sugar and oxygen concentrations by studies using a novel bench scale bioreactor. 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