{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/53957"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/53957","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"The Role of e-Antigen in Hepatitis B Infection","abstract":"Mathematical modeling of biological systems has improved the knowledge of scientists for many years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, a particle produced by hepatitis B virus, in the pathogenesis of hepatitis B infection. To accomplish this goal, I will provide biological background as well as previous modeling work on the role of e-Antigen in hepatitis B virus infection, before finally developing a new model adapted specifically for connecting hepatitis B progression with e-Antigen and drug therapy. I will analyze the model both analytically and numerically, fit it to virus data from humans chronically infected with hepatitis B that undergo drug therapy, and draw conclusions about the relation between drugs, immune activation, and loss of e-Antigen.","abstract_html":"Mathematical modeling of biological systems has improved the knowledge of scientists for many years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, a particle produced by hepatitis B virus, in the pathogenesis of hepatitis B infection. To accomplish this goal, I will provide biological background as well as previous modeling work on the role of e-Antigen in hepatitis B virus infection, before finally developing a new model adapted specifically for connecting hepatitis B progression with e-Antigen and drug therapy. I will analyze the model both analytically and numerically, fit it to virus data from humans chronically infected with hepatitis B that undergo drug therapy, and draw conclusions about the relation between drugs, immune activation, and loss of e-Antigen.","abstract_has_math":false,"creators":["Saul, April Leigh"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Mathematics","degree_department":"Mathematics","school":null,"contributors":[],"advisors":[],"committee_chairs":["Ciupe, Stanca M."],"committee_members":["Zietsman, Lizette","Chung, Matthias"],"year":2015,"date_issued":"2015-06-29","date_published":"2015-06-29","updated_at":"2026-07-22T22:18:53Z","subjects":["Mathematical modeling","Hepatitis B Virus","e-Antigen"],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["vt_gsexam:5112"],"render_values":[{"text":"vt_gsexam:5112","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/53957","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Ciupe, Stanca M."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Zietsman, Lizette","Chung, Matthias"]},{"key":"dc:contributor.department","label":"Department","values":["Mathematics"]},{"key":"dc:creator","label":"Author","values":["Saul, April Leigh"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-06-30T08:03:15Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-06-30T08:03:15Z"]},{"key":"dc:date.issued","label":"Date","values":["2015-06-29"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mathematics"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Mathematical modeling","Hepatitis B Virus","e-Antigen"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["vt_gsexam:5112"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/53957"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Mathematical modeling of biological systems has improved the knowledge of scientists for many years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, a particle produced by hepatitis B virus, in the pathogenesis of hepatitis B infection. To accomplish this goal, I will provide biological background as well as previous modeling work on the role of e-Antigen in hepatitis B virus infection, before finally developing a new model adapted specifically for connecting hepatitis B progression with e-Antigen and drug therapy. I will analyze the model both analytically and numerically, fit it to virus data from humans chronically infected with hepatitis B that undergo drug therapy, and draw conclusions about the relation between drugs, immune activation, and loss of e-Antigen."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["ETD"]},{"key":"dc:title","label":"Title","values":["The Role of e-Antigen in Hepatitis B Infection"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Ciupe, Stanca M."],"dc:contributor.committeemember":["Zietsman, Lizette","Chung, Matthias"],"dc:contributor.department":["Mathematics"],"dc:creator":["Saul, April Leigh"],"dc:date.accessioned":["2015-06-30T08:03:15Z"],"dc:date.available":["2015-06-30T08:03:15Z"],"dc:date.issued":["2015-06-29"],"dc:description.abstract":["Mathematical modeling of biological systems has improved the knowledge of scientists for many years. 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