Calcium-boro-saccharate-gluconate: studies of preparation, toxicology and effect on serum calcium level in cows

From the results of the previously described experiments, the following conclusions were drawn: 1. Boric acid increases the solubility of calcium d-saccharate in water. An increase in the concentration of boric acid results in an increase in the solubility of the saccharate. 2. Boric acid in solution reacts with calcium d-saccharate to form a new compound to which the name calcium boro-saccharate has been given. 3. A solution containing 10 parts acid, 37.5 parts calcium d-saccharate and 100 parts calcium gluconate in 500 parts distilled water is stable and is less toxic for rabbits and no more toxic for cows, when injected intravenously, than is the commercial product, Calcium-Boro-Gluconate. 4. The intravenous injection of either of these solutions into cows causes an immediate, marked rise in the serum calcium level. This rise is followed by a rapid drop, and, in the case of C-B-S-G Solution, there is a second rise in about one-half hour after injection. 5. The special centrifuge tubes for the determination of serum calcium are not reliable. Changes in construction and technic are necessary before the efficacy of such tubes can be improved.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biology

Department dc:contributor.department

Biology

Grantor dc:publisher

Virginia Agricultural and Mechanical College and Polytechnic Institute

Year dc:date.issued

1942

Author dc:creator

• Appleby, Aaron

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/10919/52070

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/52070