{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/46424"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/46424","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Impedance Measurement of Cells; Experiment and Analysis of Passivation Layer","abstract":"Biological cells like any other material do conduct electricity. Though they come across as insulators, the resistance to the flow of current, i.e. impedance, could be used to characterize the cell itself. In this aspect, the impedance of cells can be a promising tool to investigate the state of the cell. A simple way of measuring the impedance would be a planar-microelectrode method. The cells are contained in culture medium while measurements are taken with micro-electrodes fabricated on top of a substrate. Since both the probe \"tips\" do not come in contact with the probed object, the impedance to be measured includes some components apart from that contributed by the cells. There have been publications reporting the usage of impedance of a cell to determine changes in the state of cells due to healing, drug candidate testing, functional genomic studies and so on. In this thesis, an effort has been made to measure the impedance of cells. Further, a component of the sensor, the passivation layer has been investigated for its contribution to the measured impedance in a quantitative manner.","abstract_html":"Biological cells like any other material do conduct electricity. Though they come across as insulators, the resistance to the flow of current, i.e. impedance, could be used to characterize the cell itself. In this aspect, the impedance of cells can be a promising tool to investigate the state of the cell. A simple way of measuring the impedance would be a planar-microelectrode method. The cells are contained in culture medium while measurements are taken with micro-electrodes fabricated on top of a substrate. Since both the probe "tips" do not come in contact with the probed object, the impedance to be measured includes some components apart from that contributed by the cells. There have been publications reporting the usage of impedance of a cell to determine changes in the state of cells due to healing, drug candidate testing, functional genomic studies and so on. In this thesis, an effort has been made to measure the impedance of cells. Further, a component of the sensor, the passivation layer has been investigated for its contribution to the measured impedance in a quantitative manner.","abstract_has_math":false,"creators":["Sreedharan Nair, Shree Narayanan"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Electrical and Computer Engineering","degree_department":"Electrical and Computer Engineering","school":null,"contributors":[],"advisors":[],"committee_chairs":["Agah, Masoud"],"committee_members":["Meehan, Kathleen","Davalos, Rafael V."],"year":2009,"date_issued":"2009-11-20","date_published":"2009-11-20","updated_at":"2026-07-22T22:18:53Z","subjects":["bio-impedance","Modeling","analysis"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-12242009-232636"],"render_values":[{"text":"etd-12242009-232636","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/46424","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Agah, Masoud"]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Meehan, Kathleen","Davalos, Rafael V."]},{"key":"dc:contributor.department","label":"Department","values":["Electrical and Computer Engineering"]},{"key":"dc:creator","label":"Author","values":["Sreedharan Nair, Shree Narayanan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:52:34Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:52:34Z","2010-01-22"]},{"key":"dc:date.issued","label":"Date","values":["2009-11-20"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Electrical and Computer Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["bio-impedance","Modeling","analysis"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-12242009-232636"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/46424"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Biological cells like any other material do conduct electricity. Though they come across as insulators, the resistance to the flow of current, i.e. impedance, could be used to characterize the cell itself. In this aspect, the impedance of cells can be a promising tool to investigate the state of the cell. A simple way of measuring the impedance would be a planar-microelectrode method. The cells are contained in culture medium while measurements are taken with micro-electrodes fabricated on top of a substrate. Since both the probe \"tips\" do not come in contact with the probed object, the impedance to be measured includes some components apart from that contributed by the cells. There have been publications reporting the usage of impedance of a cell to determine changes in the state of cells due to healing, drug candidate testing, functional genomic studies and so on. In this thesis, an effort has been made to measure the impedance of cells. Further, a component of the sensor, the passivation layer has been investigated for its contribution to the measured impedance in a quantitative manner."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:title","label":"Title","values":["Impedance Measurement of Cells; Experiment and Analysis of Passivation Layer"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Agah, Masoud"],"dc:contributor.committeemember":["Meehan, Kathleen","Davalos, Rafael V."],"dc:contributor.department":["Electrical and Computer Engineering"],"dc:creator":["Sreedharan Nair, Shree Narayanan"],"dc:date.accessioned":["2014-03-14T21:52:34Z"],"dc:date.available":["2014-03-14T21:52:34Z","2010-01-22"],"dc:date.issued":["2009-11-20"],"dc:description.abstract":["Biological cells like any other material do conduct electricity. Though they come across as insulators, the resistance to the flow of current, i.e. impedance, could be used to characterize the cell itself. In this aspect, the impedance of cells can be a promising tool to investigate the state of the cell. A simple way of measuring the impedance would be a planar-microelectrode method. The cells are contained in culture medium while measurements are taken with micro-electrodes fabricated on top of a substrate. Since both the probe \"tips\" do not come in contact with the probed object, the impedance to be measured includes some components apart from that contributed by the cells. There have been publications reporting the usage of impedance of a cell to determine changes in the state of cells due to healing, drug candidate testing, functional genomic studies and so on. In this thesis, an effort has been made to measure the impedance of cells. Further, a component of the sensor, the passivation layer has been investigated for its contribution to the measured impedance in a quantitative manner."],"dc:description.degree":["Master of Science"],"dc:identifier.other":["etd-12242009-232636"],"dc:identifier.uri":["http://hdl.handle.net/10919/46424"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["bio-impedance","Modeling","analysis"],"dc:title":["Impedance Measurement of Cells; Experiment and Analysis of Passivation Layer"],"dc:type":["Thesis"],"thesis:degree_discipline":["Electrical and Computer Engineering"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:18:53Z"}