{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/46204"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/46204","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"The Development of Gelatin Based Tissue Adhesives for Use in Soft Tissue Biomedical Applications","abstract":"Experiments were performed to characterize the pH, gelation time, diffusion processes, material properties, adhesive properties, and the drying variables on the material and adhesive properties of Gelatin Resorcinol Dialdehyde (GR-DIAL) tissue adhesives by varying formulation. Three adhesive formulations with altered weight content of water and glyoxal (a dialdehyde) were utilized. The adhesive formulations were characterized by pH and gelation time in situ, and absorption/desorption of water in the formed resin. Thermal analysis, mechanical testing, and lap shear adhesive bond testing were utilized to characterize fresh GR-DIAL adhesive formulations and formulations dried at 370C. From the results, the diffusion processes, material and adhesive properties of the adhesive formulations were primarily affected by hydrogen bonding, chemical cross-linking, and the existence of bound water within the bulk adhesive. Formulations with increased glyoxal content had both a higher degree of cross-linking and proportion of bound water within the bulk adhesive. The increased number of chemical cross-links greatly increased the swelling resistance of the adhesives, while, the existence of bound water within the adhesive increased the resistance to drying, and plasticized the resin by depressing the resin glass transition temperature, and increased the adhesive ductility. Hydrogen bonding increased with increased gelatin content or decreased water content, resulting in increased strength and modulus of the adhesives as well as increased adhesive strength.","abstract_html":"Experiments were performed to characterize the pH, gelation time, diffusion processes, material properties, adhesive properties, and the drying variables on the material and adhesive properties of Gelatin Resorcinol Dialdehyde (GR-DIAL) tissue adhesives by varying formulation. Three adhesive formulations with altered weight content of water and glyoxal (a dialdehyde) were utilized. The adhesive formulations were characterized by pH and gelation time in situ, and absorption/desorption of water in the formed resin. Thermal analysis, mechanical testing, and lap shear adhesive bond testing were utilized to characterize fresh GR-DIAL adhesive formulations and formulations dried at 370C. From the results, the diffusion processes, material and adhesive properties of the adhesive formulations were primarily affected by hydrogen bonding, chemical cross-linking, and the existence of bound water within the bulk adhesive. Formulations with increased glyoxal content had both a higher degree of cross-linking and proportion of bound water within the bulk adhesive. The increased number of chemical cross-links greatly increased the swelling resistance of the adhesives, while, the existence of bound water within the adhesive increased the resistance to drying, and plasticized the resin by depressing the resin glass transition temperature, and increased the adhesive ductility. Hydrogen bonding increased with increased gelatin content or decreased water content, resulting in increased strength and modulus of the adhesives as well as increased adhesive strength.","abstract_has_math":false,"creators":["Droesch, Kristen L."],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Materials Science and Engineering","degree_department":"Materials Science and Engineering","school":null,"contributors":[],"advisors":[],"committee_chairs":["Love, Brian J."],"committee_members":["Corcoran, Sean G.","Foy, Jonette Rogers"],"year":1999,"date_issued":"1999-07-28","date_published":"1999-07-28","updated_at":"2026-07-24T05:55:57Z","subjects":["Tissue Adhesive","Gelatin","Glyoxal","Resorcinol"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-121399-111758"],"render_values":[{"text":"etd-121399-111758","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/46204","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Love, Brian J."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Corcoran, Sean G.","Foy, Jonette Rogers"]},{"key":"dc:contributor.department","label":"Department","values":["Materials Science and Engineering"]},{"key":"dc:creator","label":"Author","values":["Droesch, Kristen L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:51:25Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:51:25Z","2000-12-16"]},{"key":"dc:date.issued","label":"Date","values":["1999-07-28"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Materials Science and Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Tissue Adhesive","Gelatin","Glyoxal","Resorcinol"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-121399-111758"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/46204"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Experiments were performed to characterize the pH, gelation time, diffusion processes, material properties, adhesive properties, and the drying variables on the material and adhesive properties of Gelatin Resorcinol Dialdehyde (GR-DIAL) tissue adhesives by varying formulation. Three adhesive formulations with altered weight content of water and glyoxal (a dialdehyde) were utilized. The adhesive formulations were characterized by pH and gelation time in situ, and absorption/desorption of water in the formed resin. Thermal analysis, mechanical testing, and lap shear adhesive bond testing were utilized to characterize fresh GR-DIAL adhesive formulations and formulations dried at 370C. From the results, the diffusion processes, material and adhesive properties of the adhesive formulations were primarily affected by hydrogen bonding, chemical cross-linking, and the existence of bound water within the bulk adhesive. Formulations with increased glyoxal content had both a higher degree of cross-linking and proportion of bound water within the bulk adhesive. The increased number of chemical cross-links greatly increased the swelling resistance of the adhesives, while, the existence of bound water within the adhesive increased the resistance to drying, and plasticized the resin by depressing the resin glass transition temperature, and increased the adhesive ductility. Hydrogen bonding increased with increased gelatin content or decreased water content, resulting in increased strength and modulus of the adhesives as well as increased adhesive strength."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:title","label":"Title","values":["The Development of Gelatin Based Tissue Adhesives for Use in Soft Tissue Biomedical Applications"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Love, Brian J."],"dc:contributor.committeemember":["Corcoran, Sean G.","Foy, Jonette Rogers"],"dc:contributor.department":["Materials Science and Engineering"],"dc:creator":["Droesch, Kristen L."],"dc:date.accessioned":["2014-03-14T21:51:25Z"],"dc:date.available":["2014-03-14T21:51:25Z","2000-12-16"],"dc:date.issued":["1999-07-28"],"dc:description.abstract":["Experiments were performed to characterize the pH, gelation time, diffusion processes, material properties, adhesive properties, and the drying variables on the material and adhesive properties of Gelatin Resorcinol Dialdehyde (GR-DIAL) tissue adhesives by varying formulation. Three adhesive formulations with altered weight content of water and glyoxal (a dialdehyde) were utilized. The adhesive formulations were characterized by pH and gelation time in situ, and absorption/desorption of water in the formed resin. Thermal analysis, mechanical testing, and lap shear adhesive bond testing were utilized to characterize fresh GR-DIAL adhesive formulations and formulations dried at 370C. From the results, the diffusion processes, material and adhesive properties of the adhesive formulations were primarily affected by hydrogen bonding, chemical cross-linking, and the existence of bound water within the bulk adhesive. Formulations with increased glyoxal content had both a higher degree of cross-linking and proportion of bound water within the bulk adhesive. The increased number of chemical cross-links greatly increased the swelling resistance of the adhesives, while, the existence of bound water within the adhesive increased the resistance to drying, and plasticized the resin by depressing the resin glass transition temperature, and increased the adhesive ductility. Hydrogen bonding increased with increased gelatin content or decreased water content, resulting in increased strength and modulus of the adhesives as well as increased adhesive strength."],"dc:description.degree":["Master of Science"],"dc:identifier.other":["etd-121399-111758"],"dc:identifier.uri":["http://hdl.handle.net/10919/46204"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["Tissue Adhesive","Gelatin","Glyoxal","Resorcinol"],"dc:title":["The Development of Gelatin Based Tissue Adhesives for Use in Soft Tissue Biomedical Applications"],"dc:type":["Thesis"],"thesis:degree_discipline":["Materials Science and Engineering"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-24T05:55:57Z"}