{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/46002"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/46002","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Studies on water-soluble taxol derivatives","abstract":"The importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. The synthetic pathways to these compounds are compared and discussed.","abstract_html":"The importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. The synthetic pathways to these compounds are compared and discussed.","abstract_has_math":false,"creators":["Zhao, Zhiyang"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Chemistry","degree_department":"Chemistry","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-22T22:19:42Z","subjects":[],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-11242009-020141"],"render_values":[{"text":"etd-11242009-020141","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/46002","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Chemistry"]},{"key":"dc:creator","label":"Author","values":["Zhao, Zhiyang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:50:35Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:50:35Z","2009-11-24"]},{"key":"dc:date.issued","label":"Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-11242009-020141"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/46002"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The importance of taxol as an anticancer drug lies not only in its activity in antitumor assays but also in its unique mechanism of action. Unfortunately, taxol is not water-soluble and therefore must be given in conjunction with emulsifying agents. Modifications of taxol were carried out in order to prepare water-soluble taxol derivatives. The C-2’ hydroxyl group of taxol was substituted with various groups to increase water solubility. The synthesized taxol derivatives, 2’-((3-sulfo-1-oxopropyl)oxy)taxol sodium salt, 2’-((4-((2-sulfoethyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt, and 2’-((4-((3-sulfopropyl)amino)-1,4-dioxobutyl)oxy)taxol sodium salt were more water-soluble than taxol. 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