{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/45703"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/45703","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Some metabolic effects of high oxygen concentrations in relation to retrolental fibroplasia","abstract":"Newborn rats and young guinea pigs have been exposed to high oxygen concentrations with subsequent analyses of ascorbic acid in liver and brain tissue. Newborn vats show a depletion of liver ascorbic acid only after exposure to 100% oxygen. Extending the exposure period in 70% oxygen did not result in any depletion. Brain ascorbic acid levels in newborn rats were depleted by exposure to both 100% and 70% oxygen until the 14th day of life. After that age, exposure failed to cause depletion. Guinea pigs identically exposed showed ascorbic acid depletion in both brain and liver tissue with the more marked depletion occurring in liver tissue. Abnormalities in the eyes of the experimental guinea pigs were demonstrated. Results of the tissue Vitamin A analyses are incomplete and inconclusive at this time.","abstract_html":"Newborn rats and young guinea pigs have been exposed to high oxygen concentrations with subsequent analyses of ascorbic acid in liver and brain tissue. Newborn vats show a depletion of liver ascorbic acid only after exposure to 100% oxygen. Extending the exposure period in 70% oxygen did not result in any depletion. Brain ascorbic acid levels in newborn rats were depleted by exposure to both 100% and 70% oxygen until the 14th day of life. After that age, exposure failed to cause depletion. Guinea pigs identically exposed showed ascorbic acid depletion in both brain and liver tissue with the more marked depletion occurring in liver tissue. Abnormalities in the eyes of the experimental guinea pigs were demonstrated. Results of the tissue Vitamin A analyses are incomplete and inconclusive at this time.","abstract_has_math":false,"creators":["Swartz, Jean Gibson"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Biology","degree_department":"Biology","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1957,"date_issued":"1957","date_published":"1957","updated_at":"2026-07-22T22:19:42Z","subjects":[],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-11152013-040122"],"render_values":[{"text":"etd-11152013-040122","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/45703","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Biology"]},{"key":"dc:creator","label":"Author","values":["Swartz, Jean Gibson"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:49:42Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:49:42Z","2013-11-15"]},{"key":"dc:date.issued","label":"Date","values":["1957"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-11152013-040122"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/45703"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Newborn rats and young guinea pigs have been exposed to high oxygen concentrations with subsequent analyses of ascorbic acid in liver and brain tissue. Newborn vats show a depletion of liver ascorbic acid only after exposure to 100% oxygen. Extending the exposure period in 70% oxygen did not result in any depletion. Brain ascorbic acid levels in newborn rats were depleted by exposure to both 100% and 70% oxygen until the 14th day of life. After that age, exposure failed to cause depletion. Guinea pigs identically exposed showed ascorbic acid depletion in both brain and liver tissue with the more marked depletion occurring in liver tissue. Abnormalities in the eyes of the experimental guinea pigs were demonstrated. Results of the tissue Vitamin A analyses are incomplete and inconclusive at this time."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["BTD"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Some metabolic effects of high oxygen concentrations in relation to retrolental fibroplasia"]}]}],"canonical_facts":{"dc:contributor.department":["Biology"],"dc:creator":["Swartz, Jean Gibson"],"dc:date.accessioned":["2014-03-14T21:49:42Z"],"dc:date.available":["2014-03-14T21:49:42Z","2013-11-15"],"dc:date.issued":["1957"],"dc:description.abstract":["Newborn rats and young guinea pigs have been exposed to high oxygen concentrations with subsequent analyses of ascorbic acid in liver and brain tissue. Newborn vats show a depletion of liver ascorbic acid only after exposure to 100% oxygen. Extending the exposure period in 70% oxygen did not result in any depletion. Brain ascorbic acid levels in newborn rats were depleted by exposure to both 100% and 70% oxygen until the 14th day of life. After that age, exposure failed to cause depletion. Guinea pigs identically exposed showed ascorbic acid depletion in both brain and liver tissue with the more marked depletion occurring in liver tissue. Abnormalities in the eyes of the experimental guinea pigs were demonstrated. Results of the tissue Vitamin A analyses are incomplete and inconclusive at this time."],"dc:description.degree":["Master of Science"],"dc:format.medium":["BTD"],"dc:format.mimetype":["application/pdf"],"dc:identifier.other":["etd-11152013-040122"],"dc:identifier.uri":["http://hdl.handle.net/10919/45703"],"dc:language.iso":["en"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["Some metabolic effects of high oxygen concentrations in relation to retrolental fibroplasia"],"dc:type":["Thesis"],"dc:type.dcmitype":["Text"],"thesis:degree_discipline":["Biology"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute"]},"updated_at":"2026-07-22T22:19:42Z"}