{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/44379"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/44379","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Organo-iridium compounds: synthesis, characterization and reactivity","abstract":"Today, few water-soluble organometallic compounds are known, and little research has been done in this area. Water-soluble organometallic complexes are of interest for two reactions. First, a water-soluble compound that could be developed as a catalyst eliminates the need for organic solvents and allows the catalyst to be easily recycled. Secondly, water-soluble compounds can be introduced into biological systems, and like the water-soluble complex cisplatin may show anticancer activity. The compound, [lr(COD)(PMe3)3]CI (COD = 1,5-cyclooctadiene, Me = methyl), was synthesized and found to be water-soluble and fairly air-stable. Other water-soluble compounds, [lr(COD)(tripod)]CI, [lr(COD)(dmpe)]CI and [lrH(COD)(PMe3)3]CI2 [tripod = 1 ,1, 1-tris(diphenylphosphinomethyl)ethane, dmpe = (dimethylphosphino)ethane] were also synthesized by similar methods. All of the water-soluble compounds prepared were characterized by nmr and/or x-ray crystallography. [lr(COD)(PMe3)3]CI was found to undergo intramolecular rearrangement in solution and have a square pyramidal structure, which is unique for five-coordinate organometallic compounds. lr(COD) (tripod)]CI was also fluxional in solution, but it had the trigonal bipyramidal structure, usually observed in five-coordinate compounds. Several of the compounds synthesized were submitted to the National Cancer Institute for anticancer screening. Test results showed that the compounds exhibited some anticancer activity, but were non-selective towards a specific type of cancer. Nucleophilic addition reactions between [lr(COD)(PMe3)31CI and several nucleophiles were also studied.","abstract_html":"Today, few water-soluble organometallic compounds are known, and little research has been done in this area. Water-soluble organometallic complexes are of interest for two reactions. First, a water-soluble compound that could be developed as a catalyst eliminates the need for organic solvents and allows the catalyst to be easily recycled. Secondly, water-soluble compounds can be introduced into biological systems, and like the water-soluble complex cisplatin may show anticancer activity. The compound, [lr(COD)(PMe3)3]CI (COD = 1,5-cyclooctadiene, Me = methyl), was synthesized and found to be water-soluble and fairly air-stable. Other water-soluble compounds, [lr(COD)(tripod)]CI, [lr(COD)(dmpe)]CI and [lrH(COD)(PMe3)3]CI2 [tripod = 1 ,1, 1-tris(diphenylphosphinomethyl)ethane, dmpe = (dimethylphosphino)ethane] were also synthesized by similar methods. All of the water-soluble compounds prepared were characterized by nmr and/or x-ray crystallography. [lr(COD)(PMe3)3]CI was found to undergo intramolecular rearrangement in solution and have a square pyramidal structure, which is unique for five-coordinate organometallic compounds. lr(COD) (tripod)]CI was also fluxional in solution, but it had the trigonal bipyramidal structure, usually observed in five-coordinate compounds. Several of the compounds synthesized were submitted to the National Cancer Institute for anticancer screening. Test results showed that the compounds exhibited some anticancer activity, but were non-selective towards a specific type of cancer. Nucleophilic addition reactions between [lr(COD)(PMe3)31CI and several nucleophiles were also studied.","abstract_has_math":false,"creators":["Frazier, Joy Faith"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Chemistry","degree_department":"Chemistry","school":null,"contributors":[],"advisors":[],"committee_chairs":["Merola, Joseph S."],"committee_members":["Hanson, Brian E.","Anderson, Mark R."],"year":1991,"date_issued":"1991-01-15","date_published":"1991-01-15","updated_at":"2026-07-22T22:20:07Z","subjects":[],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-08222009-040309"],"render_values":[{"text":"etd-08222009-040309","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/44379","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Merola, Joseph S."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Hanson, Brian E.","Anderson, Mark R."]},{"key":"dc:contributor.department","label":"Department","values":["Chemistry"]},{"key":"dc:creator","label":"Author","values":["Frazier, Joy Faith"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:43:24Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:43:24Z","2009-08-22"]},{"key":"dc:date.issued","label":"Date","values":["1991-01-15"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-08222009-040309"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/44379"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Today, few water-soluble organometallic compounds are known, and little research has been done in this area. Water-soluble organometallic complexes are of interest for two reactions. First, a water-soluble compound that could be developed as a catalyst eliminates the need for organic solvents and allows the catalyst to be easily recycled. Secondly, water-soluble compounds can be introduced into biological systems, and like the water-soluble complex cisplatin may show anticancer activity. The compound, [lr(COD)(PMe3)3]CI (COD = 1,5-cyclooctadiene, Me = methyl), was synthesized and found to be water-soluble and fairly air-stable. Other water-soluble compounds, [lr(COD)(tripod)]CI, [lr(COD)(dmpe)]CI and [lrH(COD)(PMe3)3]CI2 [tripod = 1 ,1, 1-tris(diphenylphosphinomethyl)ethane, dmpe = (dimethylphosphino)ethane] were also synthesized by similar methods. All of the water-soluble compounds prepared were characterized by nmr and/or x-ray crystallography. [lr(COD)(PMe3)3]CI was found to undergo intramolecular rearrangement in solution and have a square pyramidal structure, which is unique for five-coordinate organometallic compounds. lr(COD) (tripod)]CI was also fluxional in solution, but it had the trigonal bipyramidal structure, usually observed in five-coordinate compounds. Several of the compounds synthesized were submitted to the National Cancer Institute for anticancer screening. Test results showed that the compounds exhibited some anticancer activity, but were non-selective towards a specific type of cancer. Nucleophilic addition reactions between [lr(COD)(PMe3)31CI and several nucleophiles were also studied."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["BTD"]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Organo-iridium compounds: synthesis, characterization and reactivity"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Merola, Joseph S."],"dc:contributor.committeemember":["Hanson, Brian E.","Anderson, Mark R."],"dc:contributor.department":["Chemistry"],"dc:creator":["Frazier, Joy Faith"],"dc:date.accessioned":["2014-03-14T21:43:24Z"],"dc:date.available":["2014-03-14T21:43:24Z","2009-08-22"],"dc:date.issued":["1991-01-15"],"dc:description.abstract":["Today, few water-soluble organometallic compounds are known, and little research has been done in this area. Water-soluble organometallic complexes are of interest for two reactions. First, a water-soluble compound that could be developed as a catalyst eliminates the need for organic solvents and allows the catalyst to be easily recycled. Secondly, water-soluble compounds can be introduced into biological systems, and like the water-soluble complex cisplatin may show anticancer activity. The compound, [lr(COD)(PMe3)3]CI (COD = 1,5-cyclooctadiene, Me = methyl), was synthesized and found to be water-soluble and fairly air-stable. Other water-soluble compounds, [lr(COD)(tripod)]CI, [lr(COD)(dmpe)]CI and [lrH(COD)(PMe3)3]CI2 [tripod = 1 ,1, 1-tris(diphenylphosphinomethyl)ethane, dmpe = (dimethylphosphino)ethane] were also synthesized by similar methods. All of the water-soluble compounds prepared were characterized by nmr and/or x-ray crystallography. [lr(COD)(PMe3)3]CI was found to undergo intramolecular rearrangement in solution and have a square pyramidal structure, which is unique for five-coordinate organometallic compounds. lr(COD) (tripod)]CI was also fluxional in solution, but it had the trigonal bipyramidal structure, usually observed in five-coordinate compounds. Several of the compounds synthesized were submitted to the National Cancer Institute for anticancer screening. Test results showed that the compounds exhibited some anticancer activity, but were non-selective towards a specific type of cancer. Nucleophilic addition reactions between [lr(COD)(PMe3)31CI and several nucleophiles were also studied."],"dc:description.degree":["Master of Science"],"dc:format.medium":["BTD"],"dc:format.mimetype":["application/pdf"],"dc:identifier.other":["etd-08222009-040309"],"dc:identifier.uri":["http://hdl.handle.net/10919/44379"],"dc:language.iso":["en"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["Organo-iridium compounds: synthesis, characterization and reactivity"],"dc:type":["Thesis"],"dc:type.dcmitype":["Text"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:20:07Z"}