{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/44315"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/44315","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Ruthenium-Platinum Polypyridyl Complexes: Synthesis and Characterization","abstract":"A series of bimetallic (Ru<sup>II</sup>, Pt<sup>II</sup) complexes were synthesized with the general formula [(tpy)RuCl(BL)PtCl₂](PF₆) (tpy = 2,2':6',2\"-terpyridine and BL = bridging ligand) and their spectroscopic, electrochemical, and DNA binding properties studied. The bridging ligands used in these complexes were 2,3-bis(2'-pyridyl)pyrazine (dpp), 2,3-bis(2'-pyridyl)quinoxaline (dpq) and 2,3-bis(2'-pyridyl)benzoquinoxaline (dpb). These complexes combine light-absorbing Ru<sup>II</sup>-polypyridyl chromophores and a cis-PtCl₂ structural motif known to bind DNA. The Ru-bound chloride may be substituted, enabling further modification of the spectroscopic properties. The synthesis of [(tpy)RuCl(BL)PtCl₂](PF₆) utilizes a building block approach that allows modifications to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes. The lowest-energy absorption for the three complexes is assigned to a Ru(dπ) → BL(π*) charge transfer transition. This transition shifts to lower energy as the ligand is varied from dpp to dpq to dpb. The first and second reductions are BL<sup>0/-</sup> and BL<sup>-/2-</sup> based and shift to more positive potentials from dpp to dpq to dpb. The Ru<sup>II/III</sup> redox couple remains at a nearly constant potential for the series. All three compounds show DNA binding when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration.","abstract_html":"A series of bimetallic (Ru&lt;sup&gt;II&lt;/sup&gt;, Pt&lt;sup&gt;II&lt;/sup) complexes were synthesized with the general formula [(tpy)RuCl(BL)PtCl₂](PF₆) (tpy = 2,2&#x27;:6&#x27;,2&quot;-terpyridine and BL = bridging ligand) and their spectroscopic, electrochemical, and DNA binding properties studied. The bridging ligands used in these complexes were 2,3-bis(2&#x27;-pyridyl)pyrazine (dpp), 2,3-bis(2&#x27;-pyridyl)quinoxaline (dpq) and 2,3-bis(2&#x27;-pyridyl)benzoquinoxaline (dpb). These complexes combine light-absorbing Ru&lt;sup&gt;II&lt;/sup&gt;-polypyridyl chromophores and a cis-PtCl₂ structural motif known to bind DNA. The Ru-bound chloride may be substituted, enabling further modification of the spectroscopic properties. The synthesis of [(tpy)RuCl(BL)PtCl₂](PF₆) utilizes a building block approach that allows modifications to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes. The lowest-energy absorption for the three complexes is assigned to a Ru(dπ) → BL(π*) charge transfer transition. This transition shifts to lower energy as the ligand is varied from dpp to dpq to dpb. The first and second reductions are BL&lt;sup&gt;0/-&lt;/sup&gt; and BL&lt;sup&gt;-/2-&lt;/sup&gt; based and shift to more positive potentials from dpp to dpq to dpb. The Ru&lt;sup&gt;II/III&lt;/sup&gt; redox couple remains at a nearly constant potential for the series. All three compounds show DNA binding when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration.","abstract_has_math":false,"creators":["Williams, R. Lee"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Chemistry","degree_department":"Chemistry","school":null,"contributors":[],"advisors":[],"committee_chairs":["Brewer, Karen J."],"committee_members":["Tissue, Brian M.","Deck, Paul A.","Winkel, Brenda S. J."],"year":2001,"date_issued":"2001-04-09","date_published":"2001-04-09","updated_at":"2026-07-22T22:19:21Z","subjects":["ruthenium","DNA","cisplatin","bridging ligand","platinum","polymetallic","polyazine","polypyridyl"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-08212001-145348"],"render_values":[{"text":"etd-08212001-145348","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/44315","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Brewer, Karen J."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Tissue, Brian M.","Deck, Paul A.","Winkel, Brenda S. J."]},{"key":"dc:contributor.department","label":"Department","values":["Chemistry"]},{"key":"dc:creator","label":"Author","values":["Williams, R. Lee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T21:43:07Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T21:43:07Z","2005-02-04"]},{"key":"dc:date.issued","label":"Date","values":["2001-04-09"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ruthenium","DNA","cisplatin","bridging ligand","platinum","polymetallic","polyazine","polypyridyl"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-08212001-145348"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/44315"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A series of bimetallic (Ru<sup>II</sup>, Pt<sup>II</sup) complexes were synthesized with the general formula [(tpy)RuCl(BL)PtCl₂](PF₆) (tpy = 2,2':6',2\"-terpyridine and BL = bridging ligand) and their spectroscopic, electrochemical, and DNA binding properties studied. The bridging ligands used in these complexes were 2,3-bis(2'-pyridyl)pyrazine (dpp), 2,3-bis(2'-pyridyl)quinoxaline (dpq) and 2,3-bis(2'-pyridyl)benzoquinoxaline (dpb). These complexes combine light-absorbing Ru<sup>II</sup>-polypyridyl chromophores and a cis-PtCl₂ structural motif known to bind DNA. The Ru-bound chloride may be substituted, enabling further modification of the spectroscopic properties. The synthesis of [(tpy)RuCl(BL)PtCl₂](PF₆) utilizes a building block approach that allows modifications to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes. The lowest-energy absorption for the three complexes is assigned to a Ru(dπ) → BL(π*) charge transfer transition. This transition shifts to lower energy as the ligand is varied from dpp to dpq to dpb. The first and second reductions are BL<sup>0/-</sup> and BL<sup>-/2-</sup> based and shift to more positive potentials from dpp to dpq to dpb. The Ru<sup>II/III</sup> redox couple remains at a nearly constant potential for the series. All three compounds show DNA binding when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:title","label":"Title","values":["Ruthenium-Platinum Polypyridyl Complexes: Synthesis and Characterization"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Brewer, Karen J."],"dc:contributor.committeemember":["Tissue, Brian M.","Deck, Paul A.","Winkel, Brenda S. J."],"dc:contributor.department":["Chemistry"],"dc:creator":["Williams, R. Lee"],"dc:date.accessioned":["2014-03-14T21:43:07Z"],"dc:date.available":["2014-03-14T21:43:07Z","2005-02-04"],"dc:date.issued":["2001-04-09"],"dc:description.abstract":["A series of bimetallic (Ru<sup>II</sup>, Pt<sup>II</sup) complexes were synthesized with the general formula [(tpy)RuCl(BL)PtCl₂](PF₆) (tpy = 2,2':6',2\"-terpyridine and BL = bridging ligand) and their spectroscopic, electrochemical, and DNA binding properties studied. The bridging ligands used in these complexes were 2,3-bis(2'-pyridyl)pyrazine (dpp), 2,3-bis(2'-pyridyl)quinoxaline (dpq) and 2,3-bis(2'-pyridyl)benzoquinoxaline (dpb). These complexes combine light-absorbing Ru<sup>II</sup>-polypyridyl chromophores and a cis-PtCl₂ structural motif known to bind DNA. The Ru-bound chloride may be substituted, enabling further modification of the spectroscopic properties. The synthesis of [(tpy)RuCl(BL)PtCl₂](PF₆) utilizes a building block approach that allows modifications to the series of complexes within the general synthetic scheme. This illustrates the applicability of this scheme to the development of new series of complexes. The lowest-energy absorption for the three complexes is assigned to a Ru(dπ) → BL(π*) charge transfer transition. This transition shifts to lower energy as the ligand is varied from dpp to dpq to dpb. The first and second reductions are BL<sup>0/-</sup> and BL<sup>-/2-</sup> based and shift to more positive potentials from dpp to dpq to dpb. The Ru<sup>II/III</sup> redox couple remains at a nearly constant potential for the series. All three compounds show DNA binding when incubated with linearized plasmid DNA. Adduct formation was assessed by agarose gel electrophoresis as a retardation of band migration."],"dc:description.degree":["Master of Science"],"dc:identifier.other":["etd-08212001-145348"],"dc:identifier.uri":["http://hdl.handle.net/10919/44315"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["ruthenium","DNA","cisplatin","bridging ligand","platinum","polymetallic","polyazine","polypyridyl"],"dc:title":["Ruthenium-Platinum Polypyridyl Complexes: Synthesis and Characterization"],"dc:type":["Thesis"],"thesis:degree_discipline":["Chemistry"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:19:21Z"}