The transfer of endrin via the milk to pine mouse pups and the resultant effects on hepatic microsomal activity

Many lipophilic pesticides are known to be transferred to offspring via the mother's milk. The present study was conducted to determine how much endrin was transferred from endrin resistant and susceptible dams to their suckling pups and to further characterize the effects that endrin may have on the hepatic mixed function oxidase (MFO) system in the pups. Dosing of the dams with endrin began one day after birth with either (l) oral doses of endrin in corn oil or (2) a mixture of endrin in ground feed. The total amount of endrin in the pup was determined by gas chromatography. MFO activity was determined in 2-1/2 week old pups and for adult animals using maximal activities for the demethylation of ethylmorphine and hydroxylation of aniline. No difference in the amount of endrin present in the pups was observed between strains provided both received equal amounts of endrin. MFO activity for endrin dosed mature animals and for 2-1/2 week old pups from endrin dosed dams exhibited a significant decrease from control activities. There was no difference in MFO activities between age groups. A significantly higher ethylmorphine demethylase activity was observed in comparing the resistant to the susceptible strain but there was no significant difference in aniline hydroxylase activity.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Biochemistry and Nutrition

Department dc:contributor.department

Biochemistry and Nutrition

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

1974

Author dc:creator

• Hundley, Stephen Gilbert

Chair dc:contributor.committeechair

• Webb, Ryland E.

Committee members dc:contributor.committeemember

• Campbell, T. Colin
• Eaton, John L.

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

etd-07242012-040021

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/43882