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Virginia Tech
The synthesis of amino- and deutero- sugars from halo-cyclohexadiene-cis-diols
Abstract
dc:description.abstractA versatile method for the preparation of 2-amino-2-deoxy-, 3-amino-3-deoxy-, 4- amino-4-deoxy-, and 5-amino-5-deoxy-sugars from noncarbohydrate precursors, halobenzenes 1 (Figure 1), has been developed. See: Figure 1: Aminosugar Targets from Halobenzenes This methodology has also been applied to achieve the synthesis of protected D-mannose- 2,3,4,5,6-d₅ 191, and derivatives thereof, from the metabolite d₅- bromocyclohexadiene-cis-diol 189 obtained from the microbial oxidation of d₅- bromobenzene 2 (Figure 2). See: Figure 2: Perdeuterated Sugar Synthesis
Degree
thesis:*- Name thesis:degree_name
- Ph. D.
- Level thesis:degree_level
- doctoral
- Discipline thesis:degree_discipline
- Chemistry
- Department dc:contributor.department
- Chemistry
- Grantor dc:publisher
- Virginia Tech
- Year dc:date.issued
- 1995
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Pitzer, Kevin K.
- Chair dc:contributor.committeechair
-
- Hudlicky, Tomas
- Committee members dc:contributor.committeemember
-
- Tanko, James M.
- Gibson, Harry W.
- Merola, Joseph S.
- White, Robert H.
Rights
dc:rights- Statement dc:rights
-
- In Copyright
- Licence dc:rights.uri
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Dc Identifier Other
- etd-06062008-155317
- OAI identifier oai:identifier
- oai:vtechworks.lib.vt.edu:10919/38104