Abstract
dc:description.abstractBiocatalytic conversion of chlorobenzene to the corresponding homochiral cyclohexadiene cis-diol (113) allows, through careful symmetry-based planning, the stereodivergent synthesis of all sphingosine stereoisomers. This was achieved via the selective preparation of the appropriate diastereomer of azido alcohol (118), were C-4 and C-5 correspond to C-3 and C-2 of the sphingosine skeleton, respectively (Scheme 1).
Degree
thesis:*- Name thesis:degree_name
- Ph. D.
- Level thesis:degree_level
- doctoral
- Discipline thesis:degree_discipline
- Chemistry
- Department dc:contributor.department
- Chemistry
- Grantor dc:publisher
- Virginia Tech
- Year dc:date.issued
- 1995
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Nugent, Thomas C.
- Chair dc:contributor.committeechair
-
- Hudlicky, Tomas
- Committee members dc:contributor.committeemember
-
- Tanko, James M.
- White, Robert H.
- Gibson, Harry W.
- Brewer, Karen J.
Rights
dc:rights- Statement dc:rights
-
- In Copyright
- Licence dc:rights.uri
- Language dc:language.iso
- en
Identifiers
dc:identifier.*- Dc Identifier Other
- etd-06062008-152643
- OAI identifier oai:identifier
- oai:vtechworks.lib.vt.edu:10919/38065