{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/36760"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/36760","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Periodontal Healing of Canine Experimental Grade III Furcation Defects Treated With Autologous Fibrinogen and Resolut® Barrier Membrane","abstract":"Experimental grade III furcation defects were developed bilaterally at the second and fourth premolars in 18 conditioned, laboratory-source, adult Beagles and maintained for 12 weeks. All defects were treated with debridement and mucoperiosteal flap repositioning alone, or with the addition of autologous fibrinogen, Resolut® barrier membrane, or autologous fibrinogen and Resolut® barrier membrane. The defects were analyzed by digital subtraction radiography, histopathologic, and histomorphometric analysis of healing at 1, 3, and 6 months post-treatment to determine: percent increase in defect bone volume, height and area, and length of periodontal regeneration along the perimeter of the defect. Comparisons at post-treatment intervals indicated significantly (P < 0.05) greater healing of debridement and autologous fibrinogen treated defects at 3 months, however by 6 months there were no significant differences in defect healing for all histomorphometric parameters. Defects receiving Resolut® were associated with significantly less root ankylosis. Defects receiving debridement alone had significantly greater increases in bone volume, as calculated with digital subtraction radiography, at 6 months post-treatment compared with groups receiving Resolut®. There was a significant correlation between regenerated bone area, bone volume, and periodontal regeneration for all treatments at 3 and 6 months post-treatment. In this study autologous fibrinogen and Resolut® barrier membrane did not enhance the amount of periodontal healing compared with debridement only. However, Resolut® treated defects were essentially absent of root ankylosis. Therefore, canine periodontitis causing grade III furcation involvement may respond equally well to conservative periodontal surgery compared with guided tissue regenerative techniques. However, the prevention of root ankylosis may provide a substantial benefit favoring this latter methodology.","abstract_html":"Experimental grade III furcation defects were developed bilaterally at the second and fourth premolars in 18 conditioned, laboratory-source, adult Beagles and maintained for 12 weeks. All defects were treated with debridement and mucoperiosteal flap repositioning alone, or with the addition of autologous fibrinogen, Resolut® barrier membrane, or autologous fibrinogen and Resolut® barrier membrane. The defects were analyzed by digital subtraction radiography, histopathologic, and histomorphometric analysis of healing at 1, 3, and 6 months post-treatment to determine: percent increase in defect bone volume, height and area, and length of periodontal regeneration along the perimeter of the defect. Comparisons at post-treatment intervals indicated significantly (P &lt; 0.05) greater healing of debridement and autologous fibrinogen treated defects at 3 months, however by 6 months there were no significant differences in defect healing for all histomorphometric parameters. Defects receiving Resolut® were associated with significantly less root ankylosis. Defects receiving debridement alone had significantly greater increases in bone volume, as calculated with digital subtraction radiography, at 6 months post-treatment compared with groups receiving Resolut®. There was a significant correlation between regenerated bone area, bone volume, and periodontal regeneration for all treatments at 3 and 6 months post-treatment. In this study autologous fibrinogen and Resolut® barrier membrane did not enhance the amount of periodontal healing compared with debridement only. However, Resolut® treated defects were essentially absent of root ankylosis. Therefore, canine periodontitis causing grade III furcation involvement may respond equally well to conservative periodontal surgery compared with guided tissue regenerative techniques. However, the prevention of root ankylosis may provide a substantial benefit favoring this latter methodology.","abstract_has_math":false,"creators":["Bianucci, Henri Chapman"],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Small Animal Clinical Sciences","degree_department":"Small Animal Clinical Sciences","school":null,"contributors":[],"advisors":[],"committee_chairs":["Smith, Mark M."],"committee_members":["Feldman, Bernard F.","Saunders, Geoffrey K.","Carrig, Colin B.","Johnston, Spencer A."],"year":1998,"date_issued":"1998-05-26","date_published":"1998-05-26","updated_at":"2026-07-22T22:18:47Z","subjects":["guided tissue regeneration","periodontitis","furcation","barrier membrane","periodontal","digital subtraction radiography"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-51098-11121"],"render_values":[{"text":"etd-51098-11121","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/36760","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Smith, Mark M."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Feldman, Bernard F.","Saunders, Geoffrey K.","Carrig, Colin B.","Johnston, Spencer A."]},{"key":"dc:contributor.department","label":"Department","values":["Small Animal Clinical Sciences"]},{"key":"dc:creator","label":"Author","values":["Bianucci, Henri Chapman"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-03-14T20:51:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-03-14T20:51:43Z","1999-07-08"]},{"key":"dc:date.issued","label":"Date","values":["1998-05-26"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Small Animal Clinical Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["guided tissue regeneration","periodontitis","furcation","barrier membrane","periodontal","digital subtraction radiography"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["etd-51098-11121"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/36760"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Experimental grade III furcation defects were developed bilaterally at the second and fourth premolars in 18 conditioned, laboratory-source, adult Beagles and maintained for 12 weeks. All defects were treated with debridement and mucoperiosteal flap repositioning alone, or with the addition of autologous fibrinogen, Resolut® barrier membrane, or autologous fibrinogen and Resolut® barrier membrane. The defects were analyzed by digital subtraction radiography, histopathologic, and histomorphometric analysis of healing at 1, 3, and 6 months post-treatment to determine: percent increase in defect bone volume, height and area, and length of periodontal regeneration along the perimeter of the defect. Comparisons at post-treatment intervals indicated significantly (P < 0.05) greater healing of debridement and autologous fibrinogen treated defects at 3 months, however by 6 months there were no significant differences in defect healing for all histomorphometric parameters. Defects receiving Resolut® were associated with significantly less root ankylosis. Defects receiving debridement alone had significantly greater increases in bone volume, as calculated with digital subtraction radiography, at 6 months post-treatment compared with groups receiving Resolut®. There was a significant correlation between regenerated bone area, bone volume, and periodontal regeneration for all treatments at 3 and 6 months post-treatment. In this study autologous fibrinogen and Resolut® barrier membrane did not enhance the amount of periodontal healing compared with debridement only. However, Resolut® treated defects were essentially absent of root ankylosis. Therefore, canine periodontitis causing grade III furcation involvement may respond equally well to conservative periodontal surgery compared with guided tissue regenerative techniques. However, the prevention of root ankylosis may provide a substantial benefit favoring this latter methodology."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:title","label":"Title","values":["Periodontal Healing of Canine Experimental Grade III Furcation Defects Treated With Autologous Fibrinogen and Resolut® Barrier Membrane"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Smith, Mark M."],"dc:contributor.committeemember":["Feldman, Bernard F.","Saunders, Geoffrey K.","Carrig, Colin B.","Johnston, Spencer A."],"dc:contributor.department":["Small Animal Clinical Sciences"],"dc:creator":["Bianucci, Henri Chapman"],"dc:date.accessioned":["2014-03-14T20:51:43Z"],"dc:date.available":["2014-03-14T20:51:43Z","1999-07-08"],"dc:date.issued":["1998-05-26"],"dc:description.abstract":["Experimental grade III furcation defects were developed bilaterally at the second and fourth premolars in 18 conditioned, laboratory-source, adult Beagles and maintained for 12 weeks. All defects were treated with debridement and mucoperiosteal flap repositioning alone, or with the addition of autologous fibrinogen, Resolut® barrier membrane, or autologous fibrinogen and Resolut® barrier membrane. The defects were analyzed by digital subtraction radiography, histopathologic, and histomorphometric analysis of healing at 1, 3, and 6 months post-treatment to determine: percent increase in defect bone volume, height and area, and length of periodontal regeneration along the perimeter of the defect. Comparisons at post-treatment intervals indicated significantly (P < 0.05) greater healing of debridement and autologous fibrinogen treated defects at 3 months, however by 6 months there were no significant differences in defect healing for all histomorphometric parameters. Defects receiving Resolut® were associated with significantly less root ankylosis. Defects receiving debridement alone had significantly greater increases in bone volume, as calculated with digital subtraction radiography, at 6 months post-treatment compared with groups receiving Resolut®. There was a significant correlation between regenerated bone area, bone volume, and periodontal regeneration for all treatments at 3 and 6 months post-treatment. In this study autologous fibrinogen and Resolut® barrier membrane did not enhance the amount of periodontal healing compared with debridement only. However, Resolut® treated defects were essentially absent of root ankylosis. Therefore, canine periodontitis causing grade III furcation involvement may respond equally well to conservative periodontal surgery compared with guided tissue regenerative techniques. However, the prevention of root ankylosis may provide a substantial benefit favoring this latter methodology."],"dc:description.degree":["Master of Science"],"dc:identifier.other":["etd-51098-11121"],"dc:identifier.uri":["http://hdl.handle.net/10919/36760"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["guided tissue regeneration","periodontitis","furcation","barrier membrane","periodontal","digital subtraction radiography"],"dc:title":["Periodontal Healing of Canine Experimental Grade III Furcation Defects Treated With Autologous Fibrinogen and Resolut® Barrier Membrane"],"dc:type":["Thesis"],"thesis:degree_discipline":["Small Animal Clinical Sciences"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:18:47Z"}