Applications of Control Charts in Medicine and Epidemiology

We consider two applications of control charts in health care. The first involves the comparison of four methods designed to detect an increase in the incidence rate of a rare health event, such as a congenital malformation. A number of methods have been proposed: among these are the Sets method, two modifications of the Sets method, and the CUSUM method based on the Poisson distribution. Many of the previously published comparisons of these methods used unrealistic assumptions or ignored implicit assumptions which led to misleading conclusions. We consider the situation where data are observed as a sequence of Bernoulli trials and propose the Bernoulli CUSUM chart as a desirable method for the surveillance of rare health events. We compare the steady-state average run length performance of the Sets methods and its modifications to the Bernoulli CUSUM chart under a wide variety of circumstances. Except in a very few instances we find that the Bernoulli CUSUM chart performs better than the Sets method and its modifications for the extensive number of cases considered. The second application area involves monitoring clinical outcomes, which requires accounting for the fact that each patient has a different risk of death prior to undergoing a health care procedure. We propose a risk-adjusted survival time CUSUM chart (RAST CUSUM) for monitoring clinical outcomes where the primary endpoint is a continuous, time-to-event variable that is right censored. Risk adjustment is accomplished using accelerated failure time regression models. We compare the average run length performance of the RAST CUSUM chart to the risk-adjusted Bernoulli CUSUM chart, using data from cardiac surgeries to motivate the details of the comparison. The comparisons show that the RAST CUSUM chart is more efficient at detecting deterioration in the quality of a clinical procedure than the risk-adjusted Bernoulli CUSUM chart, especially when the fraction of censored observations is not too high. We address details regarding the implementation of a prospective monitoring scheme using the RAST CUSUM chart.

Name thesis:degree_name

Ph. D.

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Statistics

Department dc:contributor.department

Statistics

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2006

Author dc:creator

• Sego, Landon Hugh

Chairs dc:contributor.committeechair

• Woodall, William H.
• Reynolds, Marion R. Jr.

Committee members dc:contributor.committeemember

• Spitzner, Dan J.
• Vining, G. Geoffrey
• Birch, Jeffrey B.

• Sets
• monitoring
• CUSCORE
• steady-state
• control chart
• risk-adjusted
• survival time
• CUSUM

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Dc Identifier Other

etd-04122006-182352

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/26795