{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/19249"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/19249","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Dispersive Characteristics of Left Ventricle Filling Waves","abstract":"Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle (LV). Despite the prevalence of this disease, it remains difficult to diagnose, mainly due to inherent compensatory mechanisms and a limited physical understanding of the filling process. LV filling can be non-invasively imaged using color m-mode echocardiography which provides a spatio-temporal map of inflow velocity. These filling patterns, or waves, are conventionally used to qualitatively assess the filling pattern, however, this work aims to physically quantify the filling waves to improve understanding of diastole and develop robust, reliable, and quantitative parameters. This work reveals that LV filling waves in a normal ventricle act as dispersive waves and not only propagate along the length of the LV but also spread and disperse in the direction of the apex. In certain diseased ventricles, this dispersion is limited due to changes in LV geometry and wall motion. This improved understanding could aid LVDD diagnostics not only for determining health and disease, but also for distinguishing between progressing disease states. This work also identifies a limitation in a current LVDD parameter, intra ventricular pressure difference (IVPD), and presents a new methodology to address this limitation. This methodology is also capable of synthesizing velocity information from a series of heartbeats to generating one representative heartbeat, addressing inaccuracies due to beat-to-beat variations. This single beat gives a comprehensive picture of that specific patient's filling pattern. Together, these methods improve the clinical utility of IVPD, making it more robust and limiting the chance for a misdiagnosis.","abstract_html":"Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle (LV). Despite the prevalence of this disease, it remains difficult to diagnose, mainly due to inherent compensatory mechanisms and a limited physical understanding of the filling process. LV filling can be non-invasively imaged using color m-mode echocardiography which provides a spatio-temporal map of inflow velocity. These filling patterns, or waves, are conventionally used to qualitatively assess the filling pattern, however, this work aims to physically quantify the filling waves to improve understanding of diastole and develop robust, reliable, and quantitative parameters. This work reveals that LV filling waves in a normal ventricle act as dispersive waves and not only propagate along the length of the LV but also spread and disperse in the direction of the apex. In certain diseased ventricles, this dispersion is limited due to changes in LV geometry and wall motion. This improved understanding could aid LVDD diagnostics not only for determining health and disease, but also for distinguishing between progressing disease states. This work also identifies a limitation in a current LVDD parameter, intra ventricular pressure difference (IVPD), and presents a new methodology to address this limitation. This methodology is also capable of synthesizing velocity information from a series of heartbeats to generating one representative heartbeat, addressing inaccuracies due to beat-to-beat variations. This single beat gives a comprehensive picture of that specific patient's filling pattern. Together, these methods improve the clinical utility of IVPD, making it more robust and limiting the chance for a misdiagnosis.","abstract_has_math":false,"creators":["Niebel, Casandra L."],"institution":"Virginia Tech","degree_name":"Master of Science","degree_level":"masters","degree_discipline":"Mechanical Engineering","degree_department":"Mechanical Engineering","school":null,"contributors":[],"advisors":[],"committee_chairs":["Vlachos, Pavlos P."],"committee_members":["Little, William Campbell","Grant, John Wallace","Jung, Sunghwan"],"year":2013,"date_issued":"2013-01-07","date_published":"2013-01-07","updated_at":"2026-07-22T22:19:45Z","subjects":["Left Ventricular Diastolic Dysfunction","Dispersive Waves","Intraventricular Pressure Difference","Color M-Mode Echocardiography"],"languages":[],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["vt_gsexam:205"],"render_values":[{"text":"vt_gsexam:205","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10919/19249","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.committeechair","label":"Committee Chair","values":["Vlachos, Pavlos P."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Little, William Campbell","Grant, John Wallace","Jung, Sunghwan"]},{"key":"dc:contributor.department","label":"Department","values":["Mechanical Engineering"]},{"key":"dc:creator","label":"Author","values":["Niebel, Casandra L."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2013-02-19T22:40:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2013-02-19T22:40:41Z"]},{"key":"dc:date.issued","label":"Date","values":["2013-01-07"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Tech"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Mechanical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Left Ventricular Diastolic Dysfunction","Dispersive Waves","Intraventricular Pressure Difference","Color M-Mode Echocardiography"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.other","label":"Dc Identifier Other","values":["vt_gsexam:205"]},{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/19249"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle (LV). Despite the prevalence of this disease, it remains difficult to diagnose, mainly due to inherent compensatory mechanisms and a limited physical understanding of the filling process. LV filling can be non-invasively imaged using color m-mode echocardiography which provides a spatio-temporal map of inflow velocity. These filling patterns, or waves, are conventionally used to qualitatively assess the filling pattern, however, this work aims to physically quantify the filling waves to improve understanding of diastole and develop robust, reliable, and quantitative parameters. This work reveals that LV filling waves in a normal ventricle act as dispersive waves and not only propagate along the length of the LV but also spread and disperse in the direction of the apex. In certain diseased ventricles, this dispersion is limited due to changes in LV geometry and wall motion. This improved understanding could aid LVDD diagnostics not only for determining health and disease, but also for distinguishing between progressing disease states. This work also identifies a limitation in a current LVDD parameter, intra ventricular pressure difference (IVPD), and presents a new methodology to address this limitation. This methodology is also capable of synthesizing velocity information from a series of heartbeats to generating one representative heartbeat, addressing inaccuracies due to beat-to-beat variations. This single beat gives a comprehensive picture of that specific patient's filling pattern. Together, these methods improve the clinical utility of IVPD, making it more robust and limiting the chance for a misdiagnosis."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["Master of Science"]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["ETD"]},{"key":"dc:title","label":"Title","values":["Dispersive Characteristics of Left Ventricle Filling Waves"]}]}],"canonical_facts":{"dc:contributor.committeechair":["Vlachos, Pavlos P."],"dc:contributor.committeemember":["Little, William Campbell","Grant, John Wallace","Jung, Sunghwan"],"dc:contributor.department":["Mechanical Engineering"],"dc:creator":["Niebel, Casandra L."],"dc:date.accessioned":["2013-02-19T22:40:41Z"],"dc:date.available":["2013-02-19T22:40:41Z"],"dc:date.issued":["2013-01-07"],"dc:description.abstract":["Left ventricular diastolic dysfunction (LVDD) is any abnormality in the filling of the left ventricle (LV). Despite the prevalence of this disease, it remains difficult to diagnose, mainly due to inherent compensatory mechanisms and a limited physical understanding of the filling process. LV filling can be non-invasively imaged using color m-mode echocardiography which provides a spatio-temporal map of inflow velocity. These filling patterns, or waves, are conventionally used to qualitatively assess the filling pattern, however, this work aims to physically quantify the filling waves to improve understanding of diastole and develop robust, reliable, and quantitative parameters. This work reveals that LV filling waves in a normal ventricle act as dispersive waves and not only propagate along the length of the LV but also spread and disperse in the direction of the apex. In certain diseased ventricles, this dispersion is limited due to changes in LV geometry and wall motion. This improved understanding could aid LVDD diagnostics not only for determining health and disease, but also for distinguishing between progressing disease states. This work also identifies a limitation in a current LVDD parameter, intra ventricular pressure difference (IVPD), and presents a new methodology to address this limitation. This methodology is also capable of synthesizing velocity information from a series of heartbeats to generating one representative heartbeat, addressing inaccuracies due to beat-to-beat variations. This single beat gives a comprehensive picture of that specific patient's filling pattern. Together, these methods improve the clinical utility of IVPD, making it more robust and limiting the chance for a misdiagnosis."],"dc:description.degree":["Master of Science"],"dc:format.medium":["ETD"],"dc:identifier.other":["vt_gsexam:205"],"dc:identifier.uri":["http://hdl.handle.net/10919/19249"],"dc:publisher":["Virginia Tech"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:subject":["Left Ventricular Diastolic Dysfunction","Dispersive Waves","Intraventricular Pressure Difference","Color M-Mode Echocardiography"],"dc:title":["Dispersive Characteristics of Left Ventricle Filling Waves"],"dc:type":["Thesis"],"thesis:degree_discipline":["Mechanical Engineering"],"thesis:degree_level":["masters"],"thesis:degree_name":["Master of Science"],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:19:45Z"}