Recent Advances on Statistical Network Analysis and Multi-task Learning for Complex Data

Real-world data are increasingly complex, arising from diverse domains that demand sophisticated analytical approaches. This dissertation focuses on developing advanced statistical methods to address the challenges in analyzing social network data and clinical trial data. First, I propose a novel exponential random graph model (ERGM) to study the common knowledge (CK) phenomenon in Facebook social networks. Unlike traditional contagion models, CK allows individuals to coordinate their activation as a group, thereby facilitating both the initiation and propagation of information. To investigate how network structure influences CK-based contagion, I develop an ERGM to generate networks while controlling for bicliques, which are the characterizing graph substructures for generating CK. Second, according to FDA guidance, prognostic variables—baseline covariates associated with clinical trial study outcomes—must be pre-specified at the study design stage to improve the precision of treatment effect estimation. To support this, I develop a multi-task learning approach that leverages historical trials of the treatment being studied to identify prognostic variables, which can guide the design and analysis of new studies. The performance is validated through simulations and demonstrated using real-world clinical trial data. In addition, I propose a frequentist dynamic borrowing approach that borrows information from the control arms of historical trials similar to the current study. This approach augments the control arm, improving the precision of estimating the treatment effect and the efficiency of conducting randomized controlled trials.

Name thesis:degree_name

Doctor of Philosophy

Level thesis:degree_level

doctoral

Discipline thesis:degree_discipline

Statistics

Department dc:contributor.department

Statistics

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2025

Author dc:creator

• Liu, Xueying

Chair dc:contributor.committeechair

• Deng, Xinwei

Committee members dc:contributor.committeemember

• Du, Pang
• Hong, Yili
• Liu, Meimei
• Kuhlman, Christopher James

• Social network data
• Clinical trial data
• Multi-task learning
• Dynamic borrowing

Statement dc:rights

• In Copyright

Licence dc:rights.uri

• http://rightsstatements.org/vocab/InC/1.0/

Language dc:language.iso

en

Dc Identifier Other

vt_gsexam:44421

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/137278