{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/118354"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/118354","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"A comparative study of the ventilatory responses of the golden hamster, Mesocricetus auratus and the laboratory rat, Rattus norvegicus, under hypercapnic and/or hypoxic gas mixtures","abstract":"Fossorial mammals are frequently exposed to hypercapnic and/or hypoxic conditions in their burrows. This research compares ventilatory responses of golden hamsters (<i>Mesocricetus auratus</i>) to different ambient respiratory gas concentrations with those of the white rat (<i>Rattus norvegicus</i>). Total body plethysmography was used to measure tidal volume (V<sub>T</sub>), respiratory frequency (R<sub>f</sub>), and minute volume (V<sub>E</sub>). The respiratory gases had carbon dioxide concentrations ranging from 0 to 790 and oxygen content ranging from 13 to 21%. Both hypercapnic and hypoxic gas mixtures caused hyperventilation in hamsters. The more a gas mixture deviated from normal air, the greater the ventilatory increase. Combining hypercapnic and hypoxic conditions did not potentiate the response. Rats exhibited a greater hyperventilation in response to hypercapnic-hypoxic and hypercapnic gas mixtures than did the hamsters. Hypoxia alone caused a greater response in the hamsters. Greater blood buffering capacity of hamsters offers a possible explanation for the different ventilatory responses observed between these two rodents.","abstract_html":"Fossorial mammals are frequently exposed to hypercapnic and/or hypoxic conditions in their burrows. This research compares ventilatory responses of golden hamsters (&lt;i&gt;Mesocricetus auratus&lt;/i&gt;) to different ambient respiratory gas concentrations with those of the white rat (&lt;i&gt;Rattus norvegicus&lt;/i&gt;). Total body plethysmography was used to measure tidal volume (V&lt;sub&gt;T&lt;/sub&gt;), respiratory frequency (R&lt;sub&gt;f&lt;/sub&gt;), and minute volume (V&lt;sub&gt;E&lt;/sub&gt;). The respiratory gases had carbon dioxide concentrations ranging from 0 to 790 and oxygen content ranging from 13 to 21%. Both hypercapnic and hypoxic gas mixtures caused hyperventilation in hamsters. The more a gas mixture deviated from normal air, the greater the ventilatory increase. Combining hypercapnic and hypoxic conditions did not potentiate the response. Rats exhibited a greater hyperventilation in response to hypercapnic-hypoxic and hypercapnic gas mixtures than did the hamsters. Hypoxia alone caused a greater response in the hamsters. Greater blood buffering capacity of hamsters offers a possible explanation for the different ventilatory responses observed between these two rodents.","abstract_has_math":false,"creators":["Holloway, Deborah Ann"],"institution":"Virginia Polytechnic Institute and State University","degree_name":"M.S.","degree_level":"masters","degree_discipline":"Zoology","degree_department":"Zoology","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1983,"date_issued":"1983","date_published":"1983","updated_at":"2026-07-22T22:19:54Z","subjects":[],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/10919/118354","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Zoology"]},{"key":"dc:creator","label":"Author","values":["Holloway, Deborah Ann"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2024-03-12T20:23:24Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2024-03-12T20:23:24Z"]},{"key":"dc:date.issued","label":"Date","values":["1983"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Polytechnic Institute and State University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Zoology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/10919/118354"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Fossorial mammals are frequently exposed to hypercapnic and/or hypoxic conditions in their burrows. This research compares ventilatory responses of golden hamsters (<i>Mesocricetus auratus</i>) to different ambient respiratory gas concentrations with those of the white rat (<i>Rattus norvegicus</i>). Total body plethysmography was used to measure tidal volume (V<sub>T</sub>), respiratory frequency (R<sub>f</sub>), and minute volume (V<sub>E</sub>). The respiratory gases had carbon dioxide concentrations ranging from 0 to 790 and oxygen content ranging from 13 to 21%. Both hypercapnic and hypoxic gas mixtures caused hyperventilation in hamsters. The more a gas mixture deviated from normal air, the greater the ventilatory increase. Combining hypercapnic and hypoxic conditions did not potentiate the response. Rats exhibited a greater hyperventilation in response to hypercapnic-hypoxic and hypercapnic gas mixtures than did the hamsters. Hypoxia alone caused a greater response in the hamsters. Greater blood buffering capacity of hamsters offers a possible explanation for the different ventilatory responses observed between these two rodents."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M.S."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["A comparative study of the ventilatory responses of the golden hamster, Mesocricetus auratus and the laboratory rat, Rattus norvegicus, under hypercapnic and/or hypoxic gas mixtures"]}]}],"canonical_facts":{"dc:contributor.department":["Zoology"],"dc:creator":["Holloway, Deborah Ann"],"dc:date.accessioned":["2024-03-12T20:23:24Z"],"dc:date.available":["2024-03-12T20:23:24Z"],"dc:date.issued":["1983"],"dc:description.abstract":["Fossorial mammals are frequently exposed to hypercapnic and/or hypoxic conditions in their burrows. This research compares ventilatory responses of golden hamsters (<i>Mesocricetus auratus</i>) to different ambient respiratory gas concentrations with those of the white rat (<i>Rattus norvegicus</i>). Total body plethysmography was used to measure tidal volume (V<sub>T</sub>), respiratory frequency (R<sub>f</sub>), and minute volume (V<sub>E</sub>). The respiratory gases had carbon dioxide concentrations ranging from 0 to 790 and oxygen content ranging from 13 to 21%. Both hypercapnic and hypoxic gas mixtures caused hyperventilation in hamsters. The more a gas mixture deviated from normal air, the greater the ventilatory increase. Combining hypercapnic and hypoxic conditions did not potentiate the response. Rats exhibited a greater hyperventilation in response to hypercapnic-hypoxic and hypercapnic gas mixtures than did the hamsters. Hypoxia alone caused a greater response in the hamsters. Greater blood buffering capacity of hamsters offers a possible explanation for the different ventilatory responses observed between these two rodents."],"dc:description.degree":["M.S."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/10919/118354"],"dc:language.iso":["en"],"dc:publisher":["Virginia Polytechnic Institute and State University"],"dc:rights":["In Copyright"],"dc:rights.uri":["http://rightsstatements.org/vocab/InC/1.0/"],"dc:title":["A comparative study of the ventilatory responses of the golden hamster, Mesocricetus auratus and the laboratory rat, Rattus norvegicus, under hypercapnic and/or hypoxic gas mixtures"],"dc:type":["Thesis"],"dc:type.dcmitype":["Text"],"thesis:degree_discipline":["Zoology"],"thesis:degree_level":["masters"],"thesis:degree_name":["M.S."],"thesis:institution_name":["Virginia Polytechnic Institute and State University"]},"updated_at":"2026-07-22T22:19:54Z"}