Multi-Focus Querying of the Human Genome using Virtual Reality and Desktop

The human genome is incredibly information dense, consisting of approximately 25,000 protein-coding genes contained within 24 unique chromosomes. An aspect of the genome that is critically important is maintaining spatial context which assists in understanding gene interactions and relationships. Existing methods of genome visualization that utilize spatial awareness are inefficient and prone to limitations in gene information and spatial context. The solution proposed in this thesis was the development and evaluation of alternative methods of genome visualization and exploration using virtual reality and desktop. To determine the optimal location of gene information within virtual reality and the influence of virtual reality, three interaction methods were implemented that interact with the ideograms. Multi-focus was applied to the ideogram interaction design to assist in visualizing multiple locations within the genome without sacrificing gene information detail or spatial awareness of the user. Two interaction methods were developed in virtual reality to determine if gene information is better suited embedded within the chromosome ideogram or separate from the ideogram. The final interaction method was implemented as a desktop application to evaluate if virtual reality provided an advantage. Results from the user study conducted determined that the use of virtual reality gave users a higher degree of confidence when navigating the chromosome ideograms and was preferred over desktop. In addition, depending on the type of task, the placement of gene information within the visualization had a notable impact on the ability of a user to work the task.

Name thesis:degree_name

Master of Science

Level thesis:degree_level

masters

Discipline thesis:degree_discipline

Computer Science & Applications

Department dc:contributor.department

Computer Science and Applications

Grantor dc:publisher

Virginia Tech

Year dc:date.issued

2023

Author dc:creator

• Reiske, Gunnar William

Chair dc:contributor.committeechair

• Yang, Yalong

Committee members dc:contributor.committeemember

• Gracanin, Denis
• Polys, Nicholas F.

• Virtual Reality
• Embodied Interaction
• Human Computer Interaction
• Multi-Focus
• Human Genome

Statement dc:rights

• Creative Commons Attribution-ShareAlike 4.0 International

Licence dc:rights.uri

• http://creativecommons.org/licenses/by-sa/4.0/

Language dc:language.iso

en

Dc Identifier Other

vt_gsexam:38150

OAI identifier oai:identifier

oai:vtechworks.lib.vt.edu:10919/115855