{"id":{"repo_id":"vt","oai_identifier":"oai:vtechworks.lib.vt.edu:10919/111009"},"canonical_url":"https://search.dev.ndltd.org/etd/vt/oai:vtechworks.lib.vt.edu:10919/111009","repository":{"repo_id":"vt","name":"Virginia Tech","base_url":"https://vtechworks.lib.vt.edu/oai/request"},"display":{"title":"Mathematical modeling of the acetone-butanol fermentation for the purposes of bioreactor design","abstract":"The acetone-butanol fermentation by Clostridium acetobutylicum is receiving renewed interest as a process for large scale solvent production. The fermentation kinetics have been modeled as functions of substrate, butyrate, and butanol concentrations and pH. These models have been applied to simulate batch, single stage stirred continuous, and two stage stirred continuous fermentations. The batch simulation results accurately reproduced trends of cell growth, acid production, and solvent production reported in experimental studies. The performance of the two stage, continuous process was shown to be vastly superior to that of the single stage process on the basis of outlet butanol concentration, volumetric productivity, and substrate utilization. The ratio of the two reactor volumes which will yield the maximum productivity was found to depend upon the feed substrate concentration and the desired effluent butanol concentration. The dilution rate necessary to achieve this optimum operating state was dependent upon the ratio of the reactor volumes.","abstract_html":"The acetone-butanol fermentation by Clostridium acetobutylicum is receiving renewed interest as a process for large scale solvent production. The fermentation kinetics have been modeled as functions of substrate, butyrate, and butanol concentrations and pH. These models have been applied to simulate batch, single stage stirred continuous, and two stage stirred continuous fermentations. The batch simulation results accurately reproduced trends of cell growth, acid production, and solvent production reported in experimental studies. The performance of the two stage, continuous process was shown to be vastly superior to that of the single stage process on the basis of outlet butanol concentration, volumetric productivity, and substrate utilization. The ratio of the two reactor volumes which will yield the maximum productivity was found to depend upon the feed substrate concentration and the desired effluent butanol concentration. The dilution rate necessary to achieve this optimum operating state was dependent upon the ratio of the reactor volumes.","abstract_has_math":false,"creators":["Gray, Gary Cecil"],"institution":"Virginia Polytechnic Institute and State University","degree_name":"M.S.","degree_level":"masters","degree_discipline":"Chemical Engineering","degree_department":"Chemical Engineering","school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1983,"date_issued":"1983","date_published":"1983","updated_at":"2026-07-22T22:18:44Z","subjects":[],"languages":["en"],"rights":["In Copyright"],"rights_urls":["http://rightsstatements.org/vocab/InC/1.0/"],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10919/111009","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.department","label":"Department","values":["Chemical Engineering"]},{"key":"dc:creator","label":"Author","values":["Gray, Gary Cecil"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2022-06-29T19:26:44Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2022-06-29T19:26:44Z"]},{"key":"dc:date.issued","label":"Date","values":["1983"]},{"key":"dc:publisher","label":"Institution","values":["Virginia Polytechnic Institute and State University"]},{"key":"dc:type","label":"Dc Type","values":["Thesis"]},{"key":"dc:type.dcmitype","label":"Dc Type Dcmitype","values":["Text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["masters"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M.S."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["Virginia Polytechnic Institute and State University"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["In Copyright"]},{"key":"dc:rights.uri","label":"Rights URI","values":["http://rightsstatements.org/vocab/InC/1.0/"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10919/111009"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The acetone-butanol fermentation by Clostridium acetobutylicum is receiving renewed interest as a process for large scale solvent production. The fermentation kinetics have been modeled as functions of substrate, butyrate, and butanol concentrations and pH. These models have been applied to simulate batch, single stage stirred continuous, and two stage stirred continuous fermentations. The batch simulation results accurately reproduced trends of cell growth, acid production, and solvent production reported in experimental studies. The performance of the two stage, continuous process was shown to be vastly superior to that of the single stage process on the basis of outlet butanol concentration, volumetric productivity, and substrate utilization. The ratio of the two reactor volumes which will yield the maximum productivity was found to depend upon the feed substrate concentration and the desired effluent butanol concentration. The dilution rate necessary to achieve this optimum operating state was dependent upon the ratio of the reactor volumes."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M.S."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Mathematical modeling of the acetone-butanol fermentation for the purposes of bioreactor design"]}]}],"canonical_facts":{"dc:contributor.department":["Chemical Engineering"],"dc:creator":["Gray, Gary Cecil"],"dc:date.accessioned":["2022-06-29T19:26:44Z"],"dc:date.available":["2022-06-29T19:26:44Z"],"dc:date.issued":["1983"],"dc:description.abstract":["The acetone-butanol fermentation by Clostridium acetobutylicum is receiving renewed interest as a process for large scale solvent production. The fermentation kinetics have been modeled as functions of substrate, butyrate, and butanol concentrations and pH. These models have been applied to simulate batch, single stage stirred continuous, and two stage stirred continuous fermentations. The batch simulation results accurately reproduced trends of cell growth, acid production, and solvent production reported in experimental studies. The performance of the two stage, continuous process was shown to be vastly superior to that of the single stage process on the basis of outlet butanol concentration, volumetric productivity, and substrate utilization. The ratio of the two reactor volumes which will yield the maximum productivity was found to depend upon the feed substrate concentration and the desired effluent butanol concentration. 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