{"id":{"repo_id":"vilnius","oai_identifier":"oai:vu.lt:elaba:2001826"},"canonical_url":"https://search.dev.ndltd.org/etd/vilnius/oai:vu.lt:elaba:2001826","repository":{"repo_id":"vilnius","name":"Vilnius University","base_url":"https://epublications.vu.lt/oai"},"display":{"title":"Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /","abstract":"Study evaluates adenosine, which is used as an adjunct to conventional reperfusion therapy (percutaneous coronary intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used for infarct-related artery (IRA) re-opening. Study evaluates influence of complementary use of adenosine in reducing the myocardial ischemic-reperfusion injury, the manifestation of slow-reflow or no-reflow phenomenon. The results of reperfusion therapy with adjunctive adenosine and without adenosine were analyzed in two homogeneous patient groups. By using new non-invasive imaging methods (single photon emission computer tomography, transthoracic Doppler echocardiography, dobutamine stress echocardiography) it was estimated, that adenosine preserves myocardial contractility and coronary flow reserve during the acute phase of myocardial infarction, reduces the final infarct size, improves the recovery of left ventricular global and segmental contractile function at five months follow-up. Those results are achieved due to adenosine impact on improving blood flow restoration not only in major coronary arteries, but also at microcirculatory level and ensuring of adequate and effective myocardial reperfusion.","abstract_html":"Study evaluates adenosine, which is used as an adjunct to conventional reperfusion therapy (percutaneous coronary intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used for infarct-related artery (IRA) re-opening. Study evaluates influence of complementary use of adenosine in reducing the myocardial ischemic-reperfusion injury, the manifestation of slow-reflow or no-reflow phenomenon. The results of reperfusion therapy with adjunctive adenosine and without adenosine were analyzed in two homogeneous patient groups. By using new non-invasive imaging methods (single photon emission computer tomography, transthoracic Doppler echocardiography, dobutamine stress echocardiography) it was estimated, that adenosine preserves myocardial contractility and coronary flow reserve during the acute phase of myocardial infarction, reduces the final infarct size, improves the recovery of left ventricular global and segmental contractile function at five months follow-up. Those results are achieved due to adenosine impact on improving blood flow restoration not only in major coronary arteries, but also at microcirculatory level and ensuring of adequate and effective myocardial reperfusion.","abstract_has_math":false,"creators":["Sadauskienė, Eglė,"],"institution":"Institutional Repository of Vilnius University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T05:55:40Z","subjects":["Reperfusion therapy ; acute myocardial infarction ; adenosine ; ischemic-reperfusion injury"],"languages":["lit"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repository.vu.lt/VU:ELABAETD2001826&prefLang=en_US","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Sadauskienė, Eglė,"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Institutional Repository of Vilnius University"]},{"key":"dc:relation","label":"Dc Relation","values":["https://epublications.vu.lt/object/elaba:2001826/2001826.pdf"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Reperfusion therapy ; acute myocardial infarction ; adenosine ; ischemic-reperfusion injury"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["lit"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.vu.lt/VU:ELABAETD2001826&prefLang=en_US"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Study evaluates adenosine, which is used as an adjunct to conventional reperfusion therapy (percutaneous coronary intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used for infarct-related artery (IRA) re-opening. Study evaluates influence of complementary use of adenosine in reducing the myocardial ischemic-reperfusion injury, the manifestation of slow-reflow or no-reflow phenomenon. The results of reperfusion therapy with adjunctive adenosine and without adenosine were analyzed in two homogeneous patient groups. By using new non-invasive imaging methods (single photon emission computer tomography, transthoracic Doppler echocardiography, dobutamine stress echocardiography) it was estimated, that adenosine preserves myocardial contractility and coronary flow reserve during the acute phase of myocardial infarction, reduces the final infarct size, improves the recovery of left ventricular global and segmental contractile function at five months follow-up. Those results are achieved due to adenosine impact on improving blood flow restoration not only in major coronary arteries, but also at microcirculatory level and ensuring of adequate and effective myocardial reperfusion."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /","Complementary role of adenosine in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction."]}]}],"canonical_facts":{"dc:creator":["Sadauskienė, Eglė,"],"dc:date":["2011"],"dc:description":["Study evaluates adenosine, which is used as an adjunct to conventional reperfusion therapy (percutaneous coronary intervention, i.e. PCI), role in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction. During the study we examined patients with the left ventricular anterior wall acute myocardial infarction (AMI), when PCI and stenting were used for infarct-related artery (IRA) re-opening. Study evaluates influence of complementary use of adenosine in reducing the myocardial ischemic-reperfusion injury, the manifestation of slow-reflow or no-reflow phenomenon. The results of reperfusion therapy with adjunctive adenosine and without adenosine were analyzed in two homogeneous patient groups. By using new non-invasive imaging methods (single photon emission computer tomography, transthoracic Doppler echocardiography, dobutamine stress echocardiography) it was estimated, that adenosine preserves myocardial contractility and coronary flow reserve during the acute phase of myocardial infarction, reduces the final infarct size, improves the recovery of left ventricular global and segmental contractile function at five months follow-up. Those results are achieved due to adenosine impact on improving blood flow restoration not only in major coronary arteries, but also at microcirculatory level and ensuring of adequate and effective myocardial reperfusion."],"dc:format":["application/pdf"],"dc:identifier":["https://repository.vu.lt/VU:ELABAETD2001826&prefLang=en_US"],"dc:language":["lit"],"dc:publisher":["Institutional Repository of Vilnius University"],"dc:relation":["https://epublications.vu.lt/object/elaba:2001826/2001826.pdf"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:subject":["Reperfusion therapy ; acute myocardial infarction ; adenosine ; ischemic-reperfusion injury"],"dc:title":["Papildomas adenozino vaidmuo mažinant infarkto dydį ir išsaugant kairiojo skilvelio funkciją pacientams, sergantiems ūminiu miokardo infarktu /","Complementary role of adenosine in reducing the infarct size and preserving the left ventricular function in patients with acute myocardial infarction."],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-24T05:55:40Z"}