{"id":{"repo_id":"vilnius","oai_identifier":"oai:vu.lt:elaba:1955869"},"canonical_url":"https://search.dev.ndltd.org/etd/vilnius/oai:vu.lt:elaba:1955869","repository":{"repo_id":"vilnius","name":"Vilnius University","base_url":"https://epublications.vu.lt/oai"},"display":{"title":"Migrena sergančių moterų ląstelinės hemostazės ir periferinių kraujagyslių kitimai /","abstract":"Migraine is a common chronic disease that is usually suffered by young people. During the attacks due to pain and other concomitant phenomena everyday activities of the patients are interrupted. Furthermore, people with migraine, especially with migraine with aura, are subject to 2-3 bigger risk of ischaemic stroke, as well as other ischaemc-blood vessel complications. The goal of the thesis is to determine the relation between migraine with aura (MA) and without aura (M0) (in women) and common cardiovascular risk factors, particularity of inflammatory markers, particularities of cellular hemostasis, as well as changes in functionality and stiffness of endothelium of peripheral blood vessels of various diameter during period between the attacks. 60 healthy women, as well as 30 with MA and 30 with M0 participated in the research. Higher systolic and diastolic blood pressure, as well as hypodynamia was registered in the M0 group. The relation between serum amyloid A, C reactive proteine and types of migraine, changes in functional activity of platelets and changes in functionality or stiffness of endothelium of peripheral blood vessels of various diameter was not proved. Women with migraine had an increased functional activity of platelets that depended on the type of migraine, frequency of attack and was more common in women with M0. In the migraine group endothelial function was unbalanced only in microcirculation. MA group demonstrated a higher flow-induced dilation than the M0 group. There was a direct relation determined between amount of platelet-monocyte aggregates and changes in microcirculation, as well as inverse relation with endothelial function in the small peripheral blood-vessels.","abstract_html":"Migraine is a common chronic disease that is usually suffered by young people. During the attacks due to pain and other concomitant phenomena everyday activities of the patients are interrupted. Furthermore, people with migraine, especially with migraine with aura, are subject to 2-3 bigger risk of ischaemic stroke, as well as other ischaemc-blood vessel complications. The goal of the thesis is to determine the relation between migraine with aura (MA) and without aura (M0) (in women) and common cardiovascular risk factors, particularity of inflammatory markers, particularities of cellular hemostasis, as well as changes in functionality and stiffness of endothelium of peripheral blood vessels of various diameter during period between the attacks. 60 healthy women, as well as 30 with MA and 30 with M0 participated in the research. Higher systolic and diastolic blood pressure, as well as hypodynamia was registered in the M0 group. The relation between serum amyloid A, C reactive proteine and types of migraine, changes in functional activity of platelets and changes in functionality or stiffness of endothelium of peripheral blood vessels of various diameter was not proved. Women with migraine had an increased functional activity of platelets that depended on the type of migraine, frequency of attack and was more common in women with M0. In the migraine group endothelial function was unbalanced only in microcirculation. MA group demonstrated a higher flow-induced dilation than the M0 group. There was a direct relation determined between amount of platelet-monocyte aggregates and changes in microcirculation, as well as inverse relation with endothelial function in the small peripheral blood-vessels.","abstract_has_math":false,"creators":["Marcijonienė, Aušra,"],"institution":"Institutional Repository of Vilnius University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Šapoka, Virginijus"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2011,"date_issued":"2011","date_published":"2011","updated_at":"2026-07-24T05:55:35Z","subjects":["migraine ; acivity of platelets ; blood-vessels function"],"languages":["lit"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://repository.vu.lt/VU:ELABAETD1955869&prefLang=en_US","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Šapoka, Virginijus"]},{"key":"dc:creator","label":"Author","values":["Marcijonienė, Aušra,"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2011"]},{"key":"dc:publisher","label":"Institution","values":["Institutional Repository of Vilnius University"]},{"key":"dc:relation","label":"Dc Relation","values":["https://epublications.vu.lt/object/elaba:1955869/1955869.pdf"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["migraine ; acivity of platelets ; blood-vessels function"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["lit"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://repository.vu.lt/VU:ELABAETD1955869&prefLang=en_US"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Migraine is a common chronic disease that is usually suffered by young people. During the attacks due to pain and other concomitant phenomena everyday activities of the patients are interrupted. Furthermore, people with migraine, especially with migraine with aura, are subject to 2-3 bigger risk of ischaemic stroke, as well as other ischaemc-blood vessel complications. The goal of the thesis is to determine the relation between migraine with aura (MA) and without aura (M0) (in women) and common cardiovascular risk factors, particularity of inflammatory markers, particularities of cellular hemostasis, as well as changes in functionality and stiffness of endothelium of peripheral blood vessels of various diameter during period between the attacks. 60 healthy women, as well as 30 with MA and 30 with M0 participated in the research. Higher systolic and diastolic blood pressure, as well as hypodynamia was registered in the M0 group. The relation between serum amyloid A, C reactive proteine and types of migraine, changes in functional activity of platelets and changes in functionality or stiffness of endothelium of peripheral blood vessels of various diameter was not proved. Women with migraine had an increased functional activity of platelets that depended on the type of migraine, frequency of attack and was more common in women with M0. In the migraine group endothelial function was unbalanced only in microcirculation. MA group demonstrated a higher flow-induced dilation than the M0 group. There was a direct relation determined between amount of platelet-monocyte aggregates and changes in microcirculation, as well as inverse relation with endothelial function in the small peripheral blood-vessels."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Migrena sergančių moterų ląstelinės hemostazės ir periferinių kraujagyslių kitimai /","Particularities of the cellular hemostasis and peripherial blood – vestels function in women with migraine."]}]}],"canonical_facts":{"dc:contributor":["Šapoka, Virginijus"],"dc:creator":["Marcijonienė, Aušra,"],"dc:date":["2011"],"dc:description":["Migraine is a common chronic disease that is usually suffered by young people. During the attacks due to pain and other concomitant phenomena everyday activities of the patients are interrupted. Furthermore, people with migraine, especially with migraine with aura, are subject to 2-3 bigger risk of ischaemic stroke, as well as other ischaemc-blood vessel complications. The goal of the thesis is to determine the relation between migraine with aura (MA) and without aura (M0) (in women) and common cardiovascular risk factors, particularity of inflammatory markers, particularities of cellular hemostasis, as well as changes in functionality and stiffness of endothelium of peripheral blood vessels of various diameter during period between the attacks. 60 healthy women, as well as 30 with MA and 30 with M0 participated in the research. Higher systolic and diastolic blood pressure, as well as hypodynamia was registered in the M0 group. The relation between serum amyloid A, C reactive proteine and types of migraine, changes in functional activity of platelets and changes in functionality or stiffness of endothelium of peripheral blood vessels of various diameter was not proved. Women with migraine had an increased functional activity of platelets that depended on the type of migraine, frequency of attack and was more common in women with M0. In the migraine group endothelial function was unbalanced only in microcirculation. MA group demonstrated a higher flow-induced dilation than the M0 group. There was a direct relation determined between amount of platelet-monocyte aggregates and changes in microcirculation, as well as inverse relation with endothelial function in the small peripheral blood-vessels."],"dc:format":["application/pdf"],"dc:identifier":["https://repository.vu.lt/VU:ELABAETD1955869&prefLang=en_US"],"dc:language":["lit"],"dc:publisher":["Institutional Repository of Vilnius University"],"dc:relation":["https://epublications.vu.lt/object/elaba:1955869/1955869.pdf"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:subject":["migraine ; acivity of platelets ; blood-vessels function"],"dc:title":["Migrena sergančių moterų ląstelinės hemostazės ir periferinių kraujagyslių kitimai /","Particularities of the cellular hemostasis and peripherial blood – vestels function in women with migraine."],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-24T05:55:35Z"}