Synthetic and spectroscopic studies of 6-substituted chromone derivatives
type: CreativeWork
description: Chromones and chromone derivatives are naturally occurring compounds found in the plant kingdom; for example, baicalein was used as a diuretic and anti-allergic drug in ancient Chinese medicine. A range of chromone-2-carboxylic acids were synthesized from six substituted 2- hydroxyacetophenones. From these chromone-2-carboxylic acids, the acid chlorides were synthesized, from which chromone-2-carboxamide derivatives such as N,N-dimethykhromone- 2-carboxamide, l-[(6-bromochromon-2-yl)-carbonyl]-pyrrolidine, 1-[(6-chlorochromon-2-yl)­ carbonyl]-pyrrolidine, l-[(6-methoxychromon-2-y1)-carbony1]-pyrrolidine, l-[(6-bromochromo- 2-yl)-carbonyl]-morpholine were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a benzene ring in the chromone moiety of several chromone-2-carboxamides. The compounds synthesized were purified either by flash chromatography or recrystallization using ethanol-water. The yields of chromone-2-carboxylic acids ranged from 85-90 %, those of the chromone-2-carboxamides ranged from 40-72 %, and for the Suzuki reaction the yields ranged from 40-55 %. The compounds synthesized were analysed by I H and 13C nuclear magnetic resonance spectroscopy. The spectra of these compounds were as expected for the target compounds. The synthesized compounds were also analysed by FTIR spectroscopy for their functional groups, confirming the identities of the target compounds.
abstract: Chromones and chromone derivatives are naturally occurring compounds found in the plant kingdom; for example, baicalein was used as a diuretic and anti-allergic drug in ancient Chinese medicine. A range of chromone-2-carboxylic acids were synthesized from six substituted 2- hydroxyacetophenones. From these chromone-2-carboxylic acids, the acid chlorides were synthesized, from which chromone-2-carboxamide derivatives such as N,N-dimethykhromone- 2-carboxamide, l-[(6-bromochromon-2-yl)-carbonyl]-pyrrolidine, 1-[(6-chlorochromon-2-yl)­ carbonyl]-pyrrolidine, l-[(6-methoxychromon-2-y1)-carbony1]-pyrrolidine, l-[(6-bromochromo- 2-yl)-carbonyl]-morpholine were also synthesized. The Suzuki cross-coupling reaction was also utilized, inserting a benzene ring in the chromone moiety of several chromone-2-carboxamides. The compounds synthesized were purified either by flash chromatography or recrystallization using ethanol-water. The yields of chromone-2-carboxylic acids ranged from 85-90 %, those of the chromone-2-carboxamides ranged from 40-72 %, and for the Suzuki reaction the yields ranged from 40-55 %. The compounds synthesized were analysed by I H and 13C nuclear magnetic resonance spectroscopy. The spectra of these compounds were as expected for the target compounds. The synthesized compounds were also analysed by FTIR spectroscopy for their functional groups, confirming the identities of the target compounds.
author: Ramonetha, Thata Golden
language: en
keywords: Chromones, Synthesis, Bioactivity, Spectroscopy, Flash chromatography, UCTD
date published: 2015-05
date modified: 2026-07-27T21:57:28Z
provider: University of Venda
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: University of Venda

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11602/772