{"id":{"repo_id":"vcu","oai_identifier":"oai:scholarscompass.vcu.edu:etd-2040"},"canonical_url":"https://search.dev.ndltd.org/etd/vcu/oai:scholarscompass.vcu.edu:etd-2040","repository":{"repo_id":"vcu","name":"Virginia Commonwealth University","base_url":"https://scholarscompass.vcu.edu/do/oai/"},"display":{"title":"Comparison of Leukocyte Classes Most Likely to Cause Vascular Dysfunction in Preeclampsia","abstract":"Leukocytes are activated in women with preeclampsia, but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In this study we compared vascular infiltration of neutrophils (CD66b) with monocytes/macrophages (CD14) and lymphocytes (CD99) in normal non-pregnant women (NNP), normal pregnant women (NP), and preeclamptic women (PE). There was no significant difference in the infiltration of lymphocytes into the maternal vasculature in PE as compared to NNP or NP. There was significantly more neutrophil infiltration into the systemic vasculature in PE women than in NP and NNP women. Monocytes/macrophages were present in tissue but not in vessels. We speculate that neutrophils are the class of leukocyte that causes the majority of vascular cell dysfunction in preeclampsia.","abstract_html":"Leukocytes are activated in women with preeclampsia, but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In this study we compared vascular infiltration of neutrophils (CD66b) with monocytes/macrophages (CD14) and lymphocytes (CD99) in normal non-pregnant women (NNP), normal pregnant women (NP), and preeclamptic women (PE). There was no significant difference in the infiltration of lymphocytes into the maternal vasculature in PE as compared to NNP or NP. There was significantly more neutrophil infiltration into the systemic vasculature in PE women than in NP and NNP women. Monocytes/macrophages were present in tissue but not in vessels. We speculate that neutrophils are the class of leukocyte that causes the majority of vascular cell dysfunction in preeclampsia.","abstract_has_math":false,"creators":["Cadden, Kristen Anne"],"institution":null,"degree_name":"Master of Science","degree_level":"Thesis","degree_discipline":"Physiology","degree_department":null,"school":null,"contributors":["Dr. Scott W. Walsh"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2006,"date_issued":"2006-01-01T08:00:00Z","date_published":"2006-01-01T08:00:00Z","updated_at":"2026-07-24T05:54:47Z","subjects":["vascular infiltration","macrophages","monocytes","CD14","CD66b","lymphocytes","womens health","Life Sciences","Physiology"],"languages":[],"rights":["© The Author"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarscompass.vcu.edu/etd/1041"],"render_values":[{"text":"https://scholarscompass.vcu.edu/etd/1041","href":"https://scholarscompass.vcu.edu/etd/1041","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25772/RP16-9F56","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Dr. Scott W. Walsh"]},{"key":"dc:creator","label":"Author","values":["Cadden, Kristen Anne"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2014-07-09T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Physiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["vascular infiltration","macrophages","monocytes","CD14","CD66b","lymphocytes","womens health","Life Sciences","Physiology"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["© The Author"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.25772/RP16-9F56","https://scholarscompass.vcu.edu/etd/1041"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Leukocytes are activated in women with preeclampsia, but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In this study we compared vascular infiltration of neutrophils (CD66b) with monocytes/macrophages (CD14) and lymphocytes (CD99) in normal non-pregnant women (NNP), normal pregnant women (NP), and preeclamptic women (PE). There was no significant difference in the infiltration of lymphocytes into the maternal vasculature in PE as compared to NNP or NP. There was significantly more neutrophil infiltration into the systemic vasculature in PE women than in NP and NNP women. Monocytes/macrophages were present in tissue but not in vessels. We speculate that neutrophils are the class of leukocyte that causes the majority of vascular cell dysfunction in preeclampsia."]},{"key":"dc:title","label":"Title","values":["Comparison of Leukocyte Classes Most Likely to Cause Vascular Dysfunction in Preeclampsia"]}]}],"canonical_facts":{"dc:contributor":["Dr. Scott W. Walsh"],"dc:creator":["Cadden, Kristen Anne"],"dc:date.available":["2014-07-09T07:00:00Z"],"dc:description.abstract":["Leukocytes are activated in women with preeclampsia, but the class of leukocyte most likely to cause vascular dysfunction is not known. We hypothesized that neutrophils may be the class of leukocyte most involved in causing this dysfunction because neutrophils are the most abundant of the leukocytes and their numbers increase during pregnancy. In this study we compared vascular infiltration of neutrophils (CD66b) with monocytes/macrophages (CD14) and lymphocytes (CD99) in normal non-pregnant women (NNP), normal pregnant women (NP), and preeclamptic women (PE). There was no significant difference in the infiltration of lymphocytes into the maternal vasculature in PE as compared to NNP or NP. There was significantly more neutrophil infiltration into the systemic vasculature in PE women than in NP and NNP women. Monocytes/macrophages were present in tissue but not in vessels. We speculate that neutrophils are the class of leukocyte that causes the majority of vascular cell dysfunction in preeclampsia."],"dc:identifier":["https://doi.org/10.25772/RP16-9F56","https://scholarscompass.vcu.edu/etd/1041"],"dc:rights":["© The Author"],"dc:subject":["vascular infiltration","macrophages","monocytes","CD14","CD66b","lymphocytes","womens health","Life Sciences","Physiology"],"dc:title":["Comparison of Leukocyte Classes Most Likely to Cause Vascular Dysfunction in Preeclampsia"],"thesis:degree_discipline":["Physiology"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T05:54:47Z"}