{"id":{"repo_id":"vcu","oai_identifier":"oai:scholarscompass.vcu.edu:etd-1018"},"canonical_url":"https://search.dev.ndltd.org/etd/vcu/oai:scholarscompass.vcu.edu:etd-1018","repository":{"repo_id":"vcu","name":"Virginia Commonwealth University","base_url":"https://scholarscompass.vcu.edu/do/oai/"},"display":{"title":"PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING","abstract":"A novel dendritic wound dressing was designed and characterized for its potential to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free environment and mimics the ECM to promote wound healing. The development of this new polymeric matrix is an important step in advancing the use of bioactive nanofibers with targeted and controlled drug delivery as a wound dressing.","abstract_html":"A novel dendritic wound dressing was designed and characterized for its potential to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free environment and mimics the ECM to promote wound healing. The development of this new polymeric matrix is an important step in advancing the use of bioactive nanofibers with targeted and controlled drug delivery as a wound dressing.","abstract_has_math":false,"creators":["Smith-Freshwater, Alicia P."],"institution":null,"degree_name":"Master of Science","degree_level":"Thesis","degree_discipline":"Biomedical Engineering","degree_department":null,"school":null,"contributors":["Hu Yang"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2009,"date_issued":"2009-08-14T07:00:00Z","date_published":"2009-08-14T07:00:00Z","updated_at":"2026-07-24T05:53:18Z","subjects":["PAMAM dendrimer","electrospinning","gelatin wound dressing","Biomedical Engineering and Bioengineering","Engineering"],"languages":[],"rights":["© The Author"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://scholarscompass.vcu.edu/etd/19"],"render_values":[{"text":"https://scholarscompass.vcu.edu/etd/19","href":"https://scholarscompass.vcu.edu/etd/19","code":true}]}]},"links":{"outbound_url":"https://doi.org/10.25772/ADHB-DE98","outbound_label":"DOI","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hu Yang"]},{"key":"dc:creator","label":"Author","values":["Smith-Freshwater, Alicia P."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2014-08-21T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biomedical Engineering"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["PAMAM dendrimer","electrospinning","gelatin wound dressing","Biomedical Engineering and Bioengineering","Engineering"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:rights","label":"Dc Rights","values":["© The Author"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.25772/ADHB-DE98","https://scholarscompass.vcu.edu/etd/19"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["A novel dendritic wound dressing was designed and characterized for its potential to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free environment and mimics the ECM to promote wound healing. The development of this new polymeric matrix is an important step in advancing the use of bioactive nanofibers with targeted and controlled drug delivery as a wound dressing."]},{"key":"dc:title","label":"Title","values":["PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING"]}]}],"canonical_facts":{"dc:contributor":["Hu Yang"],"dc:creator":["Smith-Freshwater, Alicia P."],"dc:date.available":["2014-08-21T07:00:00Z"],"dc:description.abstract":["A novel dendritic wound dressing was designed and characterized for its potential to treat chronic wounds. Comprised of gelatin, dendrimer, synthetic polymer and antibiotics, the dressing was electrospun to mimic the natural extracellular matrix (ECM). Gelatin is biocompatible, biodegradable, non-toxic, and easily available. The antibiotic, doxycycline, has the ability to inhibit matrix metalloproteinases. Matrix metalloproteinases, which occur in excess in chronic wounds, degrade the reconstituted ECM. Starburst™ polyamidoamine (PAMAM) dendrimer G3.5, which provides a versatile and structurally controlled architecture to construct nanomedicine, was covalently bonded to the gelatin backbone and electrospun into nanofibers with gelatin, doxycycline and stabilizing polymers. The proposed gelatin/dendrimer hybrid provides a bacterial free environment and mimics the ECM to promote wound healing. The development of this new polymeric matrix is an important step in advancing the use of bioactive nanofibers with targeted and controlled drug delivery as a wound dressing."],"dc:identifier":["https://doi.org/10.25772/ADHB-DE98","https://scholarscompass.vcu.edu/etd/19"],"dc:rights":["© The Author"],"dc:subject":["PAMAM dendrimer","electrospinning","gelatin wound dressing","Biomedical Engineering and Bioengineering","Engineering"],"dc:title":["PREPARATION AND CHARACTERIZATION OF AN ELECTROSPUN GELATIN/DENDRIMER HYBRID NANOFIBER DRESSING"],"thesis:degree_discipline":["Biomedical Engineering"],"thesis:degree_level":["Thesis"],"thesis:degree_name":["Master of Science"]},"updated_at":"2026-07-24T05:53:18Z"}