{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4379"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4379","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"COVID-19 In Patients with End-Stage Renal Disease - Complications, Risk Factors and Mortality // COVID-19 при пациенти с краен стадий бъбречна недостатъчност – усложнения, рискови фактори и смъртност","abstract":"The infection caused by the novel coronavirus SARS-CoV-2 has triggered a global health crisis with profound medical, social, and organisational consequences. Since the beginning of 2020, COVID-19 has become one of the most significant challenges facing modern medicine, putting healthcare systems around the world under pressure and requiring the adaptation of clinical practices to the dynamically changing epidemiological environment. Patients with chronic diseases have been particularly affected. Among the most vulnerable groups of patients are patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis. Chronic uraemia is associated with complex disorders in the immune system. In addition, patients on chronic haemodialysis are often elderly and have many comorbidities such as arterial hypertension, cardiovascular disease, and diabetes mellitus. All these factors put them at particularly high risk when exposed to SARS-CoV-2. This study followed patients on chronic haemodialysis undergoing the same treatment at St. Marina University Hospital – Varna in the period 2020-2022. The impact of COVID-19 infection on the quality of dialysis, the impact of dialysis quality on the frequency of complications in COVID-19, the survival of patients on chronic hemodialysis, as well as risk factors in patients on chronic hemodialysis and COVID-19 infection were monitored.","abstract_html":"The infection caused by the novel coronavirus SARS-CoV-2 has triggered a global health crisis with profound medical, social, and organisational consequences. Since the beginning of 2020, COVID-19 has become one of the most significant challenges facing modern medicine, putting healthcare systems around the world under pressure and requiring the adaptation of clinical practices to the dynamically changing epidemiological environment. Patients with chronic diseases have been particularly affected. Among the most vulnerable groups of patients are patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis. Chronic uraemia is associated with complex disorders in the immune system. In addition, patients on chronic haemodialysis are often elderly and have many comorbidities such as arterial hypertension, cardiovascular disease, and diabetes mellitus. All these factors put them at particularly high risk when exposed to SARS-CoV-2. This study followed patients on chronic haemodialysis undergoing the same treatment at St. Marina University Hospital – Varna in the period 2020-2022. The impact of COVID-19 infection on the quality of dialysis, the impact of dialysis quality on the frequency of complications in COVID-19, the survival of patients on chronic hemodialysis, as well as risk factors in patients on chronic hemodialysis and COVID-19 infection were monitored.","abstract_has_math":false,"creators":["Zhelyazkov, Kiril","Желязков, Кирил"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-04-02T13:06:31Z","date_published":"2026-04-02T13:06:31Z","updated_at":"2026-07-27T21:56:32Z","subjects":["renal disease","SARS-CoV-2","haemodialysis (HD)","Нефрология / Nephrology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4379","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Zhelyazkov, Kiril","Желязков, Кирил"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-04-02T13:06:31Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["renal disease","SARS-CoV-2","haemodialysis (HD)","Нефрология / Nephrology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4379"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The infection caused by the novel coronavirus SARS-CoV-2 has triggered a global health crisis with profound medical, social, and organisational consequences. Since the beginning of 2020, COVID-19 has become one of the most significant challenges facing modern medicine, putting healthcare systems around the world under pressure and requiring the adaptation of clinical practices to the dynamically changing epidemiological environment. Patients with chronic diseases have been particularly affected. Among the most vulnerable groups of patients are patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis. Chronic uraemia is associated with complex disorders in the immune system. In addition, patients on chronic haemodialysis are often elderly and have many comorbidities such as arterial hypertension, cardiovascular disease, and diabetes mellitus. All these factors put them at particularly high risk when exposed to SARS-CoV-2. This study followed patients on chronic haemodialysis undergoing the same treatment at St. Marina University Hospital – Varna in the period 2020-2022. The impact of COVID-19 infection on the quality of dialysis, the impact of dialysis quality on the frequency of complications in COVID-19, the survival of patients on chronic hemodialysis, as well as risk factors in patients on chronic hemodialysis and COVID-19 infection were monitored.","Инфекцията, причинена от новия коронавирус SARS-CoV-2, предизвика глобална здравна криза с дълбоки медицински, социални и организационни последици. От началото на 2020 година COVID-19 се превърна в едно от най-значимите предизвикателства пред съвременната медицина, поставяйки под натиск здравните системи по целия свят и изисквайки адаптиране на клиничните практики към динамично променящата се епидемиологична среда. Особено засегнати се оказаха пациентите с хронични заболявания. Сред най-уязвимите групи от пациенти се открояват болните с краен стадий на бъбречно заболяване (ESRD), провеждащи хронична хемодиализа. Хроничната уремия е свързана с комплексни нарушения в имунната система. Освен това пациентите на хронична хемодиализа са често в напреднала възраст и с много съпътстващи заболявания като артериална хипертония, сърдечно-съдови заболявания и захарен диабет. Всички тези фактори ги поставят в особено висок риск при експозиция към SARS-CoV-2. В това изследване бяха проследени пациенти на хронична хемодиализа провеждащи същата в УМБАЛ „Св. Марина“ гр. Варна в периода на 2020-2022г. като бяха проследено влиянието на COVID-19 инфекцията върху качеството на диализа, влиянието на качеството на диализата върху честотата на усложненията при COVID-19, преживяемостта на пациентите на хронична хемодиализа, както и рискови фактори при пациенти на хронична хемодиализа и COVID-19 инфекция."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["COVID-19 In Patients with End-Stage Renal Disease - Complications, Risk Factors and Mortality // COVID-19 при пациенти с краен стадий бъбречна недостатъчност – усложнения, рискови фактори и смъртност"]}]}],"canonical_facts":{"dc:creator":["Zhelyazkov, Kiril","Желязков, Кирил"],"dc:date":["2026-04-02T13:06:31Z","2025"],"dc:description":["The infection caused by the novel coronavirus SARS-CoV-2 has triggered a global health crisis with profound medical, social, and organisational consequences. Since the beginning of 2020, COVID-19 has become one of the most significant challenges facing modern medicine, putting healthcare systems around the world under pressure and requiring the adaptation of clinical practices to the dynamically changing epidemiological environment. Patients with chronic diseases have been particularly affected. Among the most vulnerable groups of patients are patients with end-stage renal disease (ESRD) undergoing chronic haemodialysis. Chronic uraemia is associated with complex disorders in the immune system. In addition, patients on chronic haemodialysis are often elderly and have many comorbidities such as arterial hypertension, cardiovascular disease, and diabetes mellitus. All these factors put them at particularly high risk when exposed to SARS-CoV-2. This study followed patients on chronic haemodialysis undergoing the same treatment at St. Marina University Hospital – Varna in the period 2020-2022. The impact of COVID-19 infection on the quality of dialysis, the impact of dialysis quality on the frequency of complications in COVID-19, the survival of patients on chronic hemodialysis, as well as risk factors in patients on chronic hemodialysis and COVID-19 infection were monitored.","Инфекцията, причинена от новия коронавирус SARS-CoV-2, предизвика глобална здравна криза с дълбоки медицински, социални и организационни последици. От началото на 2020 година COVID-19 се превърна в едно от най-значимите предизвикателства пред съвременната медицина, поставяйки под натиск здравните системи по целия свят и изисквайки адаптиране на клиничните практики към динамично променящата се епидемиологична среда. Особено засегнати се оказаха пациентите с хронични заболявания. Сред най-уязвимите групи от пациенти се открояват болните с краен стадий на бъбречно заболяване (ESRD), провеждащи хронична хемодиализа. Хроничната уремия е свързана с комплексни нарушения в имунната система. Освен това пациентите на хронична хемодиализа са често в напреднала възраст и с много съпътстващи заболявания като артериална хипертония, сърдечно-съдови заболявания и захарен диабет. Всички тези фактори ги поставят в особено висок риск при експозиция към SARS-CoV-2. В това изследване бяха проследени пациенти на хронична хемодиализа провеждащи същата в УМБАЛ „Св. Марина“ гр. Варна в периода на 2020-2022г. като бяха проследено влиянието на COVID-19 инфекцията върху качеството на диализа, влиянието на качеството на диализата върху честотата на усложненията при COVID-19, преживяемостта на пациентите на хронична хемодиализа, както и рискови фактори при пациенти на хронична хемодиализа и COVID-19 инфекция."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4379"],"dc:publisher":["Medical University of Varna"],"dc:subject":["renal disease","SARS-CoV-2","haemodialysis (HD)","Нефрология / Nephrology"],"dc:title":["COVID-19 In Patients with End-Stage Renal Disease - Complications, Risk Factors and Mortality // COVID-19 при пациенти с краен стадий бъбречна недостатъчност – усложнения, рискови фактори и смъртност"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:32Z"}