{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4376"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4376","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Study of the relationship between obesity and cardiovascular damage in an experimental model of metabolic syndrome // Изследване на връзката затлъстяване и кардиоваскуларни увреждания в експериментален модел на метаболитен синдром","abstract":"Obesity is a chronic, multifactorial disease in which the accumulation of body fat leads to adipose tissue dysfunction and the development of dyslipidemia, type 2 diabetes, atherosclerosis, and arterial hypertension—key components of the metabolic syndrome. Endothelial dysfunction, insulin resistance, chronic inflammation, and oxidative stress play crucial roles in the pathogenesis of the associated cardiovascular complications. Based on this, we formulated the hypothesis that in obesity, elevated inflammatory and oxidative markers lead to more pronounced endothelial and cardiomyocyte dysfunction, thereby promoting the progression of cardiovascular diseases. Research in this field is challenging due to the complexity of the mechanisms involved in endothelial and myocardial injury. The analysis of endothelial-protective and antioxidant agents may enhance our understanding of the processes related to the protection and partial restoration of impaired function. Despite existing data, the literature remains limited regarding the reversible manifestations of endothelial dysfunction. A promising approach is the use of experimental animal models to reproduce these alterations. The present study aims to elucidate the molecular mechanisms underlying endothelial and cardiomyocyte damage and the potential antioxidant protection, as well as to outline opportunities for future therapeutic interventions aimed at improving vascular and cardiac function in obesity.","abstract_html":"Obesity is a chronic, multifactorial disease in which the accumulation of body fat leads to adipose tissue dysfunction and the development of dyslipidemia, type 2 diabetes, atherosclerosis, and arterial hypertension—key components of the metabolic syndrome. Endothelial dysfunction, insulin resistance, chronic inflammation, and oxidative stress play crucial roles in the pathogenesis of the associated cardiovascular complications. Based on this, we formulated the hypothesis that in obesity, elevated inflammatory and oxidative markers lead to more pronounced endothelial and cardiomyocyte dysfunction, thereby promoting the progression of cardiovascular diseases. Research in this field is challenging due to the complexity of the mechanisms involved in endothelial and myocardial injury. The analysis of endothelial-protective and antioxidant agents may enhance our understanding of the processes related to the protection and partial restoration of impaired function. Despite existing data, the literature remains limited regarding the reversible manifestations of endothelial dysfunction. A promising approach is the use of experimental animal models to reproduce these alterations. The present study aims to elucidate the molecular mechanisms underlying endothelial and cardiomyocyte damage and the potential antioxidant protection, as well as to outline opportunities for future therapeutic interventions aimed at improving vascular and cardiac function in obesity.","abstract_has_math":false,"creators":["Kyuchukova, Diyana","Кючукова, Дияна"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-04-02T12:51:08Z","date_published":"2026-04-02T12:51:08Z","updated_at":"2026-07-27T21:56:32Z","subjects":["obesity","adipose tissue","cardiovascular disease","antioxidant","Физиология и патофизиология / Physiology and Pathophysiology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4376","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Kyuchukova, Diyana","Кючукова, Дияна"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-04-02T12:51:08Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["obesity","adipose tissue","cardiovascular disease","antioxidant","Физиология и патофизиология / Physiology and Pathophysiology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4376"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Obesity is a chronic, multifactorial disease in which the accumulation of body fat leads to adipose tissue dysfunction and the development of dyslipidemia, type 2 diabetes, atherosclerosis, and arterial hypertension—key components of the metabolic syndrome. Endothelial dysfunction, insulin resistance, chronic inflammation, and oxidative stress play crucial roles in the pathogenesis of the associated cardiovascular complications. Based on this, we formulated the hypothesis that in obesity, elevated inflammatory and oxidative markers lead to more pronounced endothelial and cardiomyocyte dysfunction, thereby promoting the progression of cardiovascular diseases. Research in this field is challenging due to the complexity of the mechanisms involved in endothelial and myocardial injury. The analysis of endothelial-protective and antioxidant agents may enhance our understanding of the processes related to the protection and partial restoration of impaired function. Despite existing data, the literature remains limited regarding the reversible manifestations of endothelial dysfunction. A promising approach is the use of experimental animal models to reproduce these alterations. The present study aims to elucidate the molecular mechanisms underlying endothelial and cardiomyocyte damage and the potential antioxidant protection, as well as to outline opportunities for future therapeutic interventions aimed at improving vascular and cardiac function in obesity.","Затлъстяването е хронично, мултифакторно заболяване, при което натрупването на телесни мазнини води до дисфункция на мастната тъкан и развитие на дислипидемия, диабет тип 2, атеросклероза и артериална хипертония – основни елементи на метаболитния синдром. Ендотелната дисфункция, инсулиновата резистентност, хроничното възпаление и оксидативният стрес играят ключова роля в патогенезата на свързаните кардиоваскуларни усложнения. На тази основа формулирахме хипотеза, че при затлъстяване повишените нива на възпалителни и оксидативни маркери водят до по-изразена ендотелна и кардиомиоцитна дисфункция, стимулираща прогресията на кардиоваскуларни заболявания. Изследванията в тази област са предизвикателни поради сложността на механизмите, участващи в увреждането на ендотела и миокарда. Анализът на ендотелопротективни и антиоксидантни агенти може да подобри разбирането на процесите, свързани със защита и частично възстановяване на нарушената функция. Въпреки наличните данни, литературата остава ограничена по отношение на обратимите прояви на ендотелна дисфункция. Перспективен подход е използването на експериментални животински модели за възпроизвеждане на тези нарушения. Настоящото изследване цели да изясни молекулярните механизми на увреждане и потенциалната антиоксидантна защита, както и да очертае възможности за бъдещи терапевтични интервенции, насочени към подобряване на съдовата и сърдечната функция при затлъстяване."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Study of the relationship between obesity and cardiovascular damage in an experimental model of metabolic syndrome // Изследване на връзката затлъстяване и кардиоваскуларни увреждания в експериментален модел на метаболитен синдром"]}]}],"canonical_facts":{"dc:creator":["Kyuchukova, Diyana","Кючукова, Дияна"],"dc:date":["2026-04-02T12:51:08Z","2025"],"dc:description":["Obesity is a chronic, multifactorial disease in which the accumulation of body fat leads to adipose tissue dysfunction and the development of dyslipidemia, type 2 diabetes, atherosclerosis, and arterial hypertension—key components of the metabolic syndrome. Endothelial dysfunction, insulin resistance, chronic inflammation, and oxidative stress play crucial roles in the pathogenesis of the associated cardiovascular complications. Based on this, we formulated the hypothesis that in obesity, elevated inflammatory and oxidative markers lead to more pronounced endothelial and cardiomyocyte dysfunction, thereby promoting the progression of cardiovascular diseases. Research in this field is challenging due to the complexity of the mechanisms involved in endothelial and myocardial injury. The analysis of endothelial-protective and antioxidant agents may enhance our understanding of the processes related to the protection and partial restoration of impaired function. Despite existing data, the literature remains limited regarding the reversible manifestations of endothelial dysfunction. A promising approach is the use of experimental animal models to reproduce these alterations. The present study aims to elucidate the molecular mechanisms underlying endothelial and cardiomyocyte damage and the potential antioxidant protection, as well as to outline opportunities for future therapeutic interventions aimed at improving vascular and cardiac function in obesity.","Затлъстяването е хронично, мултифакторно заболяване, при което натрупването на телесни мазнини води до дисфункция на мастната тъкан и развитие на дислипидемия, диабет тип 2, атеросклероза и артериална хипертония – основни елементи на метаболитния синдром. Ендотелната дисфункция, инсулиновата резистентност, хроничното възпаление и оксидативният стрес играят ключова роля в патогенезата на свързаните кардиоваскуларни усложнения. На тази основа формулирахме хипотеза, че при затлъстяване повишените нива на възпалителни и оксидативни маркери водят до по-изразена ендотелна и кардиомиоцитна дисфункция, стимулираща прогресията на кардиоваскуларни заболявания. Изследванията в тази област са предизвикателни поради сложността на механизмите, участващи в увреждането на ендотела и миокарда. Анализът на ендотелопротективни и антиоксидантни агенти може да подобри разбирането на процесите, свързани със защита и частично възстановяване на нарушената функция. Въпреки наличните данни, литературата остава ограничена по отношение на обратимите прояви на ендотелна дисфункция. Перспективен подход е използването на експериментални животински модели за възпроизвеждане на тези нарушения. Настоящото изследване цели да изясни молекулярните механизми на увреждане и потенциалната антиоксидантна защита, както и да очертае възможности за бъдещи терапевтични интервенции, насочени към подобряване на съдовата и сърдечната функция при затлъстяване."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4376"],"dc:publisher":["Medical University of Varna"],"dc:subject":["obesity","adipose tissue","cardiovascular disease","antioxidant","Физиология и патофизиология / Physiology and Pathophysiology"],"dc:title":["Study of the relationship between obesity and cardiovascular damage in an experimental model of metabolic syndrome // Изследване на връзката затлъстяване и кардиоваскуларни увреждания в експериментален модел на метаболитен синдром"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:32Z"}