Predictive Factors for Mortality in Young and Middle-Aged Patients with Ischemic Stroke // Предиктивни фактори за смъртен изход при пациенти с исхемичен мозъчен инсулт в млада и средна възраст

The thesis investigates the independent determinants of in-hospital mortality among patients aged 18–59 years with acute ischemic stroke. In this age group, the disease has considerable clinical and social significance, as it frequently results in long-term disability, premature death, and a substantial socioeconomic burden. A retrospective cohort, single-centre study was conducted, including 168 patients admitted to the Second Clinic of Neurology at St. Marina University Hospital – Varna between 2017 and 2022, of whom 67 died during hospitalisation, and 101 survived. Clinical, laboratory, and neuroimaging data were analysed, along with the duration of hospitalisation and the type of treatment administered. Neurological status was assessed using the NIHSS and GCS scales, while ischemic changes were evaluated by ASPECTS. Statistical analysis was performed with SPSS 20.0 and included descriptive statistics, the Mann–Whitney U test, the χ² test, and logistic regression with a significance threshold of p < 0.05. Low systolic blood pressure (≤120 mmHg), severe neurological deficit (NIHSS >15), and chronic left-sided heart failure were identified as the strongest independent predictors of fatal outcome. The study presents an original analysis of clinical, laboratory, and imaging parameters in patients aged 18–59 years, outlining a specific prognostic profile for this population.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2026

Authors dc:creator

• Kulicheva, Paola
• Куличева, Паола

• acute ischemic stroke
• neurological deficit
• heart failure
• Неврология / Neurology

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/4321

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/4321