{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4296"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4296","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение","abstract":"The thesis explores the role of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination of patients with advanced fibrosis, including examination of serum hyaluronate levels. Five risk factors for bridging fibrosis were defined: age at infection of 35 years; disease duration of 15 years; overweight; significant alcohol consumption; and transfusion route of infection. Fibrosis regression was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.","abstract_html":"The thesis explores the role of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination of patients with advanced fibrosis, including examination of serum hyaluronate levels. Five risk factors for bridging fibrosis were defined: age at infection of 35 years; disease duration of 15 years; overweight; significant alcohol consumption; and transfusion route of infection. Fibrosis regression was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.","abstract_has_math":false,"creators":["Ivanova, Irina","Иванова, Ирина"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2026,"date_issued":"2026-02-03T14:30:04Z","date_published":"2026-02-03T14:30:04Z","updated_at":"2026-07-27T21:56:56Z","subjects":["liver fibrosis","hepatitis C","virus infection","Гастроентерология / Gastroenterology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4296","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Ivanova, Irina","Иванова, Ирина"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2026-02-03T14:30:04Z","2004"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["liver fibrosis","hepatitis C","virus infection","Гастроентерология / Gastroenterology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4296"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis explores the role of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination of patients with advanced fibrosis, including examination of serum hyaluronate levels. Five risk factors for bridging fibrosis were defined: age at infection of 35 years; disease duration of 15 years; overweight; significant alcohol consumption; and transfusion route of infection. Fibrosis regression was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.","Темата. изследва ролята на съвременните методи за комплексна диагноза на чернодробната фиброза и резултатите от приложението им при 205 пациенти с хронична хепатит С-вирусна инфекция: чернодробна биопсия с оценка на некроинфламаторната активност и фиброзата; автоматичен морфометричен анализ с изчисляване на площта на фиброза; клинични и лабораторни показатели за неинвазивно определяне на пациентите с напреднала фиброза, включващо изследване серумното ниво на хиалуроната. Дефинираха 5 рискови фактори за мостова фиброза: възраст при заразяване 35 год.; давност на заболяването 15 год.; наднормено тегло; значима алкохолна консумация и трансфузионен път на инфектиране. Установява регресия на фиброзата след терапия с интерферон-алфа и рибавирин в 50 процента от случаите с вирусна ерадикация и прогресия на фиброзата при не отговорили на лечението."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение"]}]}],"canonical_facts":{"dc:creator":["Ivanova, Irina","Иванова, Ирина"],"dc:date":["2026-02-03T14:30:04Z","2004"],"dc:description":["The thesis explores the role of modern methods for comprehensive diagnosis of liver fibrosis and the results of their application in 205 patients with chronic hepatitis C virus infection: liver biopsy with assessment of necroinflammatory activity and fibrosis; automatic morphometric analysis with calculation of the area of fibrosis; clinical and laboratory indicators for non-invasive determination of patients with advanced fibrosis, including examination of serum hyaluronate levels. Five risk factors for bridging fibrosis were defined: age at infection of 35 years; disease duration of 15 years; overweight; significant alcohol consumption; and transfusion route of infection. Fibrosis regression was observed after interferon-alpha and ribavirin therapy in 50 percent of the cases, with viral eradication and fibrosis progression in those who did not respond to treatment.","Темата. изследва ролята на съвременните методи за комплексна диагноза на чернодробната фиброза и резултатите от приложението им при 205 пациенти с хронична хепатит С-вирусна инфекция: чернодробна биопсия с оценка на некроинфламаторната активност и фиброзата; автоматичен морфометричен анализ с изчисляване на площта на фиброза; клинични и лабораторни показатели за неинвазивно определяне на пациентите с напреднала фиброза, включващо изследване серумното ниво на хиалуроната. Дефинираха 5 рискови фактори за мостова фиброза: възраст при заразяване 35 год.; давност на заболяването 15 год.; наднормено тегло; значима алкохолна консумация и трансфузионен път на инфектиране. Установява регресия на фиброзата след терапия с интерферон-алфа и рибавирин в 50 процента от случаите с вирусна ерадикация и прогресия на фиброзата при не отговорили на лечението."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4296"],"dc:publisher":["Medical University of Varna"],"dc:subject":["liver fibrosis","hepatitis C","virus infection","Гастроентерология / Gastroenterology"],"dc:title":["Liver Fibrosis in Chronic Hepatitis C Virus Infection: Diagnosis, Dynamics, And Clinical Significance // Чернодробна фиброза при хроничната хепатит C-вирусна инфекция:диагностика, динамика и клинично значение"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:56Z"}