{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4259"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4259","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Microbiological Profile of Purulent-Septic Diseases in Maxillofacial Surgery // Микробиологичен профил на гнойно-септичните заболявания в лицево-челюстната хирургия","abstract":"This thesis presents an in-depth retrospective analysis of the microbiological profile of purulent-septic diseases in the maxillofacial region (MFR), treated at St. Marina University Hospital – Varna city, Bulgaria, over a ten-year period (2015–2024). The aim is to create an up-to-date \"microbiological map\" for the region, supporting the optimisation of local therapeutic protocols and the fight against antimicrobial resistance. The study employs a retrospective, observational, and descriptive design, based on the analysis of 1735 microbiological results from samples (pus, aspirates, wound secretions) obtained from patients with a clinical diagnosis of MFR abscess or phlegmon. Each isolated pathogenic microorganism was recorded as a separate isolate. Samples were divided into odontogenic (n=1033) and non-odontogenic (n=702) infections, and temporal analysis was conducted across two 5-year periods (2015-2019 and 2020-2024). Microbiological methods include standard inoculation onto culture media (blood agar, chocolate agar) and incubation under aerobic, microaerophilic, and anaerobic conditions, followed by identification through macro- and micromorphological characteristics, Gram staining, and biochemical tests. Statistical analysis utilised descriptive statistics (absolute frequencies and relative proportions). The goals include: determining the overall etiological structure of infections; conducting a comparative analysis of the microbiological profile in odontogenic and non-odontogenic origins; tracking the dynamics of the main causative agents over time (before and after the Covid-19 pandemic); and analysing the frequency of polymicrobial infections and samples without a proven causative agent, discussing the possible reasons. The expected results will provide valuable scientific information on dominant pathogens, trends in their distribution, etiological differences, and diagnostic challenges, contributing to the improvement of local therapeutic practice and the fight against antimicrobial resistance.","abstract_html":"This thesis presents an in-depth retrospective analysis of the microbiological profile of purulent-septic diseases in the maxillofacial region (MFR), treated at St. Marina University Hospital – Varna city, Bulgaria, over a ten-year period (2015–2024). The aim is to create an up-to-date "microbiological map" for the region, supporting the optimisation of local therapeutic protocols and the fight against antimicrobial resistance. The study employs a retrospective, observational, and descriptive design, based on the analysis of 1735 microbiological results from samples (pus, aspirates, wound secretions) obtained from patients with a clinical diagnosis of MFR abscess or phlegmon. Each isolated pathogenic microorganism was recorded as a separate isolate. Samples were divided into odontogenic (n=1033) and non-odontogenic (n=702) infections, and temporal analysis was conducted across two 5-year periods (2015-2019 and 2020-2024). Microbiological methods include standard inoculation onto culture media (blood agar, chocolate agar) and incubation under aerobic, microaerophilic, and anaerobic conditions, followed by identification through macro- and micromorphological characteristics, Gram staining, and biochemical tests. Statistical analysis utilised descriptive statistics (absolute frequencies and relative proportions). The goals include: determining the overall etiological structure of infections; conducting a comparative analysis of the microbiological profile in odontogenic and non-odontogenic origins; tracking the dynamics of the main causative agents over time (before and after the Covid-19 pandemic); and analysing the frequency of polymicrobial infections and samples without a proven causative agent, discussing the possible reasons. The expected results will provide valuable scientific information on dominant pathogens, trends in their distribution, etiological differences, and diagnostic challenges, contributing to the improvement of local therapeutic practice and the fight against antimicrobial resistance.","abstract_has_math":false,"creators":["Mechkarova, Iliana","Мечкарова, Илиана"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-12-19T11:52:36Z","date_published":"2025-12-19T11:52:36Z","updated_at":"2026-07-27T21:56:56Z","subjects":["septic disease","maxillofacial","polymicrobial infection","Хирургия / Surgery"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4259","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mechkarova, Iliana","Мечкарова, Илиана"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-12-19T11:52:36Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["septic disease","maxillofacial","polymicrobial infection","Хирургия / Surgery"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4259"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["This thesis presents an in-depth retrospective analysis of the microbiological profile of purulent-septic diseases in the maxillofacial region (MFR), treated at St. Marina University Hospital – Varna city, Bulgaria, over a ten-year period (2015–2024). The aim is to create an up-to-date \"microbiological map\" for the region, supporting the optimisation of local therapeutic protocols and the fight against antimicrobial resistance. The study employs a retrospective, observational, and descriptive design, based on the analysis of 1735 microbiological results from samples (pus, aspirates, wound secretions) obtained from patients with a clinical diagnosis of MFR abscess or phlegmon. Each isolated pathogenic microorganism was recorded as a separate isolate. Samples were divided into odontogenic (n=1033) and non-odontogenic (n=702) infections, and temporal analysis was conducted across two 5-year periods (2015-2019 and 2020-2024). Microbiological methods include standard inoculation onto culture media (blood agar, chocolate agar) and incubation under aerobic, microaerophilic, and anaerobic conditions, followed by identification through macro- and micromorphological characteristics, Gram staining, and biochemical tests. Statistical analysis utilised descriptive statistics (absolute frequencies and relative proportions). The goals include: determining the overall etiological structure of infections; conducting a comparative analysis of the microbiological profile in odontogenic and non-odontogenic origins; tracking the dynamics of the main causative agents over time (before and after the Covid-19 pandemic); and analysing the frequency of polymicrobial infections and samples without a proven causative agent, discussing the possible reasons. The expected results will provide valuable scientific information on dominant pathogens, trends in their distribution, etiological differences, and diagnostic challenges, contributing to the improvement of local therapeutic practice and the fight against antimicrobial resistance.","Дисертацията представя задълбочен ретроспективен анализ на микробиологичния профил при гнойно-септични заболявания в лицево-челюстната област (ЛЧО), лекувани в УМБАЛ „Света Марина“ ЕАД – гр. Варна, за десетгодишен период (2015-2024 г.). Целта е създаване на актуална „микробиологична карта“ за региона, подпомагаща оптимизирането на локалните терапевтични протоколи и борбата с антимикробната резистентност. Изследването е с ретроспективен, наблюдателен и описателен дизайн, базиран на анализ на 1735 микробиологични резултата от проби (гной, пунктати, раневи секрети) от пациенти с клинична диагноза абсцес или флегмон в ЛЧО. Всеки изолиран патогенен микроорганизъм е отчетен като отделен изолат. Пробите са разделени на одонтогенни (n=1033) и неодонтогенни (n=702) инфекции, а времевият анализ е проведен в два 5-годишни периода (2015-2019 г. и 2020-2024 г.). Микробиологичните методи включват стандартно посяване върху хранителни среди (кръвен агар, шоколадов агар) и инкубация при аеробни, микроаерофилни и анаеробни условия, последвана от идентификация чрез макро- и микроморфологични характеристики, оцветяване по Грам и биохимични тестове. Статистическият анализ използва описателна статистика (абсолютни честоти и относителни дялове). Задачите включват: определяне на общата етиологична структура на инфекциите; сравнителен анализ на микробиологичния профил при одонтогенен и неодонтогенен произход; проследяване динамиката на основните причинители във времето (преди и след пандемията от Covid-19); и анализ на честотата на полимикробните инфекции и пробите без доказан причинител, обсъждайки възможните причини. Очакваните резултати ще предоставят ценна научна информация за доминиращите патогени, тенденциите в тяхното разпространение, разликите в етиологията и предизвикателствата пред диагностиката, допринасяйки за подобряване на локалната терапевтична практика и борбата с антимикробната резистентност."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Microbiological Profile of Purulent-Septic Diseases in Maxillofacial Surgery // Микробиологичен профил на гнойно-септичните заболявания в лицево-челюстната хирургия"]}]}],"canonical_facts":{"dc:creator":["Mechkarova, Iliana","Мечкарова, Илиана"],"dc:date":["2025-12-19T11:52:36Z","2025"],"dc:description":["This thesis presents an in-depth retrospective analysis of the microbiological profile of purulent-septic diseases in the maxillofacial region (MFR), treated at St. Marina University Hospital – Varna city, Bulgaria, over a ten-year period (2015–2024). The aim is to create an up-to-date \"microbiological map\" for the region, supporting the optimisation of local therapeutic protocols and the fight against antimicrobial resistance. The study employs a retrospective, observational, and descriptive design, based on the analysis of 1735 microbiological results from samples (pus, aspirates, wound secretions) obtained from patients with a clinical diagnosis of MFR abscess or phlegmon. Each isolated pathogenic microorganism was recorded as a separate isolate. Samples were divided into odontogenic (n=1033) and non-odontogenic (n=702) infections, and temporal analysis was conducted across two 5-year periods (2015-2019 and 2020-2024). Microbiological methods include standard inoculation onto culture media (blood agar, chocolate agar) and incubation under aerobic, microaerophilic, and anaerobic conditions, followed by identification through macro- and micromorphological characteristics, Gram staining, and biochemical tests. Statistical analysis utilised descriptive statistics (absolute frequencies and relative proportions). The goals include: determining the overall etiological structure of infections; conducting a comparative analysis of the microbiological profile in odontogenic and non-odontogenic origins; tracking the dynamics of the main causative agents over time (before and after the Covid-19 pandemic); and analysing the frequency of polymicrobial infections and samples without a proven causative agent, discussing the possible reasons. The expected results will provide valuable scientific information on dominant pathogens, trends in their distribution, etiological differences, and diagnostic challenges, contributing to the improvement of local therapeutic practice and the fight against antimicrobial resistance.","Дисертацията представя задълбочен ретроспективен анализ на микробиологичния профил при гнойно-септични заболявания в лицево-челюстната област (ЛЧО), лекувани в УМБАЛ „Света Марина“ ЕАД – гр. Варна, за десетгодишен период (2015-2024 г.). Целта е създаване на актуална „микробиологична карта“ за региона, подпомагаща оптимизирането на локалните терапевтични протоколи и борбата с антимикробната резистентност. Изследването е с ретроспективен, наблюдателен и описателен дизайн, базиран на анализ на 1735 микробиологични резултата от проби (гной, пунктати, раневи секрети) от пациенти с клинична диагноза абсцес или флегмон в ЛЧО. Всеки изолиран патогенен микроорганизъм е отчетен като отделен изолат. Пробите са разделени на одонтогенни (n=1033) и неодонтогенни (n=702) инфекции, а времевият анализ е проведен в два 5-годишни периода (2015-2019 г. и 2020-2024 г.). Микробиологичните методи включват стандартно посяване върху хранителни среди (кръвен агар, шоколадов агар) и инкубация при аеробни, микроаерофилни и анаеробни условия, последвана от идентификация чрез макро- и микроморфологични характеристики, оцветяване по Грам и биохимични тестове. Статистическият анализ използва описателна статистика (абсолютни честоти и относителни дялове). Задачите включват: определяне на общата етиологична структура на инфекциите; сравнителен анализ на микробиологичния профил при одонтогенен и неодонтогенен произход; проследяване динамиката на основните причинители във времето (преди и след пандемията от Covid-19); и анализ на честотата на полимикробните инфекции и пробите без доказан причинител, обсъждайки възможните причини. Очакваните резултати ще предоставят ценна научна информация за доминиращите патогени, тенденциите в тяхното разпространение, разликите в етиологията и предизвикателствата пред диагностиката, допринасяйки за подобряване на локалната терапевтична практика и борбата с антимикробната резистентност."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4259"],"dc:publisher":["Medical University of Varna"],"dc:subject":["septic disease","maxillofacial","polymicrobial infection","Хирургия / Surgery"],"dc:title":["Microbiological Profile of Purulent-Septic Diseases in Maxillofacial Surgery // Микробиологичен профил на гнойно-септичните заболявания в лицево-челюстната хирургия"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:56Z"}