{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4258"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4258","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Centralised Preparation of Medicinal Products for Systemic Treatment of Malignant Diseases in Hospital Pharmacies in Bulgaria – Specifics, Challenges and Prospects // Централизирано разтваряне на лекарствени продукти за системно лечение на злокачествени заболявания в болничните аптеки в България – специфики, предизвикателства и перспективи","abstract":"A legal change to introduce centralised preparation of medicinal products for systemic treatment of malignant diseases in Bulgaria was made at the end of 2015, and there is no regulatory document that specifies exactly what competencies are required to perform it. The purpose of this thesis is to study and analyse the process and the training of personnel for the implementation of this specific pharmaceutical activity. To achieve the goal, the following main tasks were addressed: studying, analysing, and providing recommendations to the legislation governing the process; and studying hospitals and pharmaceutical personnel related to the centralised preparation of cytotoxics. The unusable residues of dissolved drugs reimbursed by the NHIF were analysed. Historical, documentary, statistical, and graphical methods were used, as well as the interview method, through which the study was conducted. The results obtained show that: - The number of hospitals in which the process is carried out is increasing, but not all of them comply with the regulations. - The value of unused cytostatic residues reimbursed by the NHIF is increasing annually, with the trend being a decrease in active units and an increase in value. - Pharmacists preparing solutions are mainly female master pharmacists, aged 36-50, most of whom have undergone some training voluntarily. - The legislation needs improvement. The study analyses the centralised preparation of cytostatics in Bulgaria for the first time.","abstract_html":"A legal change to introduce centralised preparation of medicinal products for systemic treatment of malignant diseases in Bulgaria was made at the end of 2015, and there is no regulatory document that specifies exactly what competencies are required to perform it. The purpose of this thesis is to study and analyse the process and the training of personnel for the implementation of this specific pharmaceutical activity. To achieve the goal, the following main tasks were addressed: studying, analysing, and providing recommendations to the legislation governing the process; and studying hospitals and pharmaceutical personnel related to the centralised preparation of cytotoxics. The unusable residues of dissolved drugs reimbursed by the NHIF were analysed. Historical, documentary, statistical, and graphical methods were used, as well as the interview method, through which the study was conducted. The results obtained show that: - The number of hospitals in which the process is carried out is increasing, but not all of them comply with the regulations. - The value of unused cytostatic residues reimbursed by the NHIF is increasing annually, with the trend being a decrease in active units and an increase in value. - Pharmacists preparing solutions are mainly female master pharmacists, aged 36-50, most of whom have undergone some training voluntarily. - The legislation needs improvement. The study analyses the centralised preparation of cytostatics in Bulgaria for the first time.","abstract_has_math":false,"creators":["Grigorova, Velina","Григорова, Велина"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-12-19T11:42:03Z","date_published":"2025-12-19T11:42:03Z","updated_at":"2026-07-27T21:56:54Z","subjects":["centralised preparation","hazardous drugs","residues","systemic treatment","training","hospital pharmacy","Болнична фармация / Hospital pharmacy"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4258","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Grigorova, Velina","Григорова, Велина"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-12-19T11:42:03Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["centralised preparation","hazardous drugs","residues","systemic treatment","training","hospital pharmacy","Болнична фармация / Hospital pharmacy"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4258"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A legal change to introduce centralised preparation of medicinal products for systemic treatment of malignant diseases in Bulgaria was made at the end of 2015, and there is no regulatory document that specifies exactly what competencies are required to perform it. The purpose of this thesis is to study and analyse the process and the training of personnel for the implementation of this specific pharmaceutical activity. To achieve the goal, the following main tasks were addressed: studying, analysing, and providing recommendations to the legislation governing the process; and studying hospitals and pharmaceutical personnel related to the centralised preparation of cytotoxics. The unusable residues of dissolved drugs reimbursed by the NHIF were analysed. Historical, documentary, statistical, and graphical methods were used, as well as the interview method, through which the study was conducted. The results obtained show that: - The number of hospitals in which the process is carried out is increasing, but not all of them comply with the regulations. - The value of unused cytostatic residues reimbursed by the NHIF is increasing annually, with the trend being a decrease in active units and an increase in value. - Pharmacists preparing solutions are mainly female master pharmacists, aged 36-50, most of whom have undergone some training voluntarily. - The legislation needs improvement. The study analyses the centralised preparation of cytostatics in Bulgaria for the first time.","Законова промяна за въвеждане на централизираното разтваряне на лекарства за системно лечение на злокачествени заболявания в България се прави в края на 2015 г. като няма нормативен документ, който да указва какви точно са необходимите компетенции за извършване му. Целта на настоящия дисертационен труд е проучване и анализиране на процеса и подготовката на персонала за осъществяването на тази специфична фармацевтична дейност. За постигане на целта са решени следните основни задачи: проучване, анализ и препоръки към законодателството обуславящо процеса; изследване на болниците и фармацевтичния персонал свързани с централизираното приготвяне на цитостатици. Анализирани са реимбурсираните от НЗОК неизползваеми остатъци от разтворените лекарства. Използвани са исторически, документален, статистически и графичен метод, както и метод-интервю, чрез които се извърши изследването. Получените резултати показват, че: - броят на болниците, в които се извършва процесът, се увеличава, но не всички спазват нормативната уредба; - стойността на реимбурсираните от НЗОК неизползваеми остатъци от цитостатици се увеличава ежегодно, като тенденцията е намаляване на активните единици, а увеличаване на стойността; - Фармацевтите, приготвящи разтвори, са предимно жени магистър-фармацевти, на възраст 36-50 г., повечето от които са минали някакво обучение доброволно; - законодателството се нуждае от усъвършенстване. Настоящият труд прави за пръв път анализ на централизираното разтваряне на цитостатици у нас."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Centralised Preparation of Medicinal Products for Systemic Treatment of Malignant Diseases in Hospital Pharmacies in Bulgaria – Specifics, Challenges and Prospects // Централизирано разтваряне на лекарствени продукти за системно лечение на злокачествени заболявания в болничните аптеки в България – специфики, предизвикателства и перспективи"]}]}],"canonical_facts":{"dc:creator":["Grigorova, Velina","Григорова, Велина"],"dc:date":["2025-12-19T11:42:03Z","2025"],"dc:description":["A legal change to introduce centralised preparation of medicinal products for systemic treatment of malignant diseases in Bulgaria was made at the end of 2015, and there is no regulatory document that specifies exactly what competencies are required to perform it. The purpose of this thesis is to study and analyse the process and the training of personnel for the implementation of this specific pharmaceutical activity. To achieve the goal, the following main tasks were addressed: studying, analysing, and providing recommendations to the legislation governing the process; and studying hospitals and pharmaceutical personnel related to the centralised preparation of cytotoxics. The unusable residues of dissolved drugs reimbursed by the NHIF were analysed. Historical, documentary, statistical, and graphical methods were used, as well as the interview method, through which the study was conducted. The results obtained show that: - The number of hospitals in which the process is carried out is increasing, but not all of them comply with the regulations. - The value of unused cytostatic residues reimbursed by the NHIF is increasing annually, with the trend being a decrease in active units and an increase in value. - Pharmacists preparing solutions are mainly female master pharmacists, aged 36-50, most of whom have undergone some training voluntarily. - The legislation needs improvement. The study analyses the centralised preparation of cytostatics in Bulgaria for the first time.","Законова промяна за въвеждане на централизираното разтваряне на лекарства за системно лечение на злокачествени заболявания в България се прави в края на 2015 г. като няма нормативен документ, който да указва какви точно са необходимите компетенции за извършване му. Целта на настоящия дисертационен труд е проучване и анализиране на процеса и подготовката на персонала за осъществяването на тази специфична фармацевтична дейност. За постигане на целта са решени следните основни задачи: проучване, анализ и препоръки към законодателството обуславящо процеса; изследване на болниците и фармацевтичния персонал свързани с централизираното приготвяне на цитостатици. Анализирани са реимбурсираните от НЗОК неизползваеми остатъци от разтворените лекарства. Използвани са исторически, документален, статистически и графичен метод, както и метод-интервю, чрез които се извърши изследването. Получените резултати показват, че: - броят на болниците, в които се извършва процесът, се увеличава, но не всички спазват нормативната уредба; - стойността на реимбурсираните от НЗОК неизползваеми остатъци от цитостатици се увеличава ежегодно, като тенденцията е намаляване на активните единици, а увеличаване на стойността; - Фармацевтите, приготвящи разтвори, са предимно жени магистър-фармацевти, на възраст 36-50 г., повечето от които са минали някакво обучение доброволно; - законодателството се нуждае от усъвършенстване. Настоящият труд прави за пръв път анализ на централизираното разтваряне на цитостатици у нас."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4258"],"dc:publisher":["Medical University of Varna"],"dc:subject":["centralised preparation","hazardous drugs","residues","systemic treatment","training","hospital pharmacy","Болнична фармация / Hospital pharmacy"],"dc:title":["Centralised Preparation of Medicinal Products for Systemic Treatment of Malignant Diseases in Hospital Pharmacies in Bulgaria – Specifics, Challenges and Prospects // Централизирано разтваряне на лекарствени продукти за системно лечение на злокачествени заболявания в болничните аптеки в България – специфики, предизвикателства и перспективи"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:54Z"}