{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4196"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4196","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Relationship of Periodontal Status and Periodontal Infection with Coronary Artery Disease // Връзка на пародонталния статус и пародонталната инфекция с коронарната болест","abstract":"The thesis examines the relationship between coronary artery disease and periodontitis. Both diseases are extremely common worldwide, and a relationship between the two has been discussed for decades, without any definitive proof. We investigated the relationship between the severity of periodontal disease, measured by clinical indicators of periodontal status, and the severity of coronary disease, measured by the SYNTAX score, in 199 patients. The influence of infection with three known periodontal pathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola, on periodontal and cardiac clinical indicators was also investigated. We found that the severity of periodontitis is associated with a more frequent presence of coronary artery atherosclerosis, and the amount of P. gingivalis in subgingival plaque correlates with the levels of C-reactive protein in the blood. The results of the study support the hypothesis of periodontal infection as a risk factor for the development of coronary artery disease and establish P. gingivalis as a mediator of systemic inflammation in the body. The study emphasises the need for enhanced periodontal prophylaxis and an integrated multidisciplinary approach in the treatment of coronary artery disease.","abstract_html":"The thesis examines the relationship between coronary artery disease and periodontitis. Both diseases are extremely common worldwide, and a relationship between the two has been discussed for decades, without any definitive proof. We investigated the relationship between the severity of periodontal disease, measured by clinical indicators of periodontal status, and the severity of coronary disease, measured by the SYNTAX score, in 199 patients. The influence of infection with three known periodontal pathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola, on periodontal and cardiac clinical indicators was also investigated. We found that the severity of periodontitis is associated with a more frequent presence of coronary artery atherosclerosis, and the amount of P. gingivalis in subgingival plaque correlates with the levels of C-reactive protein in the blood. The results of the study support the hypothesis of periodontal infection as a risk factor for the development of coronary artery disease and establish P. gingivalis as a mediator of systemic inflammation in the body. The study emphasises the need for enhanced periodontal prophylaxis and an integrated multidisciplinary approach in the treatment of coronary artery disease.","abstract_has_math":false,"creators":["Nyagolova, Atanaska","Няголова, Атанаска"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-11-06T14:37:29Z","date_published":"2025-11-06T14:37:29Z","updated_at":"2026-07-27T21:56:40Z","subjects":["coronary artery disease","periodontitis","plaque","prophylaxis","Зъболечение / Dental Treatment"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4196","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Nyagolova, Atanaska","Няголова, Атанаска"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-11-06T14:37:29Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["coronary artery disease","periodontitis","plaque","prophylaxis","Зъболечение / Dental Treatment"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4196"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis examines the relationship between coronary artery disease and periodontitis. Both diseases are extremely common worldwide, and a relationship between the two has been discussed for decades, without any definitive proof. We investigated the relationship between the severity of periodontal disease, measured by clinical indicators of periodontal status, and the severity of coronary disease, measured by the SYNTAX score, in 199 patients. The influence of infection with three known periodontal pathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola, on periodontal and cardiac clinical indicators was also investigated. We found that the severity of periodontitis is associated with a more frequent presence of coronary artery atherosclerosis, and the amount of P. gingivalis in subgingival plaque correlates with the levels of C-reactive protein in the blood. The results of the study support the hypothesis of periodontal infection as a risk factor for the development of coronary artery disease and establish P. gingivalis as a mediator of systemic inflammation in the body. The study emphasises the need for enhanced periodontal prophylaxis and an integrated multidisciplinary approach in the treatment of coronary artery disease.","Дисертационният труд разглежда връзката между коронарната болест на сърцето и пародонтита. И двете заболявания са изключително разпространени в световен мащаб, като от десетилетия се дискутира връзка между двете, без такава да е категорично доказана. В настоящият дисертационен труд е изследвана връзката между тежестта на пародонталното заболяване, измерена чрез клиничните показатели на пародонталния статус, и тежестта на коронарната болест, измерена чрез SYNTAX score при 199 пациента. Беше изследвано и влиянието на инфекцията с три известни пародонтални патогени: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis и Treponema denticola, върху пародонталните и кардиологичните клинични показатели. Установихме, че тежестта на пародонтита се асоциира с по-често наличие на атеросклероза на коронарните артерии, а количеството на P. gingivalis в субгингивалната плака корелира с нивата на C-реактивен протеин в кръвта. Резултатите от изследването подкрепят хипотезата за пародонталната инфекция като рисков фактор за развитие на коронарна болест и утвърждават P. gingivalis като медиатор на системно възпаление в организма. Изследването подчертава нуждите от засилена пародонтална профилактика и интегриран мултидисциплинарен подход в лечението на коронарната артериална болест."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Relationship of Periodontal Status and Periodontal Infection with Coronary Artery Disease // Връзка на пародонталния статус и пародонталната инфекция с коронарната болест"]}]}],"canonical_facts":{"dc:creator":["Nyagolova, Atanaska","Няголова, Атанаска"],"dc:date":["2025-11-06T14:37:29Z","2025"],"dc:description":["The thesis examines the relationship between coronary artery disease and periodontitis. Both diseases are extremely common worldwide, and a relationship between the two has been discussed for decades, without any definitive proof. We investigated the relationship between the severity of periodontal disease, measured by clinical indicators of periodontal status, and the severity of coronary disease, measured by the SYNTAX score, in 199 patients. The influence of infection with three known periodontal pathogens: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis and Treponema denticola, on periodontal and cardiac clinical indicators was also investigated. We found that the severity of periodontitis is associated with a more frequent presence of coronary artery atherosclerosis, and the amount of P. gingivalis in subgingival plaque correlates with the levels of C-reactive protein in the blood. The results of the study support the hypothesis of periodontal infection as a risk factor for the development of coronary artery disease and establish P. gingivalis as a mediator of systemic inflammation in the body. The study emphasises the need for enhanced periodontal prophylaxis and an integrated multidisciplinary approach in the treatment of coronary artery disease.","Дисертационният труд разглежда връзката между коронарната болест на сърцето и пародонтита. И двете заболявания са изключително разпространени в световен мащаб, като от десетилетия се дискутира връзка между двете, без такава да е категорично доказана. В настоящият дисертационен труд е изследвана връзката между тежестта на пародонталното заболяване, измерена чрез клиничните показатели на пародонталния статус, и тежестта на коронарната болест, измерена чрез SYNTAX score при 199 пациента. Беше изследвано и влиянието на инфекцията с три известни пародонтални патогени: Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis и Treponema denticola, върху пародонталните и кардиологичните клинични показатели. Установихме, че тежестта на пародонтита се асоциира с по-често наличие на атеросклероза на коронарните артерии, а количеството на P. gingivalis в субгингивалната плака корелира с нивата на C-реактивен протеин в кръвта. Резултатите от изследването подкрепят хипотезата за пародонталната инфекция като рисков фактор за развитие на коронарна болест и утвърждават P. gingivalis като медиатор на системно възпаление в организма. Изследването подчертава нуждите от засилена пародонтална профилактика и интегриран мултидисциплинарен подход в лечението на коронарната артериална болест."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4196"],"dc:publisher":["Medical University of Varna"],"dc:subject":["coronary artery disease","periodontitis","plaque","prophylaxis","Зъболечение / Dental Treatment"],"dc:title":["Relationship of Periodontal Status and Periodontal Infection with Coronary Artery Disease // Връзка на пародонталния статус и пародонталната инфекция с коронарната болест"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:40Z"}