{"id":{"repo_id":"varna","oai_identifier":"oai:repository.mu-varna.bg:nls/4135"},"canonical_url":"https://search.dev.ndltd.org/etd/varna/oai:repository.mu-varna.bg:nls/4135","repository":{"repo_id":"varna","name":"Medical University of Varna","base_url":"https://repository.mu-varna.bg/oai/request"},"display":{"title":"Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином","abstract":"Concomitant use of several medications often increases the risk of adverse reactions and can compromise the treatment. Because of this, the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their mechanism of action, contraindications, drug interactions, and adverse reactions. On the other hand, patients also have comorbidities, which lead to the concomitant use of a large number of drugs and the intake of special foods, nutritional supplements and herbal products that patients prescribe themselves. The listed factors place the recognition of drug interactions as one of the main challenges for physicians. The main goal is to minimise adverse events related to drug interactions and to maximise clinical efficacy, leading to increased overall survival and improved quality of life. The thesis summarises the available and collected information by using online platforms for detecting drug-drug interactions and a publicly available database for reporting adverse drug reactions, which will increase knowledge in the field of drug interactions in the treatment of non-small-cell lung cancer with epidermal growth factor receptor inhibitors.","abstract_html":"Concomitant use of several medications often increases the risk of adverse reactions and can compromise the treatment. Because of this, the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their mechanism of action, contraindications, drug interactions, and adverse reactions. On the other hand, patients also have comorbidities, which lead to the concomitant use of a large number of drugs and the intake of special foods, nutritional supplements and herbal products that patients prescribe themselves. The listed factors place the recognition of drug interactions as one of the main challenges for physicians. The main goal is to minimise adverse events related to drug interactions and to maximise clinical efficacy, leading to increased overall survival and improved quality of life. The thesis summarises the available and collected information by using online platforms for detecting drug-drug interactions and a publicly available database for reporting adverse drug reactions, which will increase knowledge in the field of drug interactions in the treatment of non-small-cell lung cancer with epidermal growth factor receptor inhibitors.","abstract_has_math":false,"creators":["Mutafova, Ivanka","Мутафова, Иванка"],"institution":"Medical University of Varna","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2025,"date_issued":"2025-07-29T13:28:58Z","date_published":"2025-07-29T13:28:58Z","updated_at":"2026-07-27T21:56:59Z","subjects":["drug-drug interactions","adverse reaction","EGFR inhibitors","Фармакология / Pharmacology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://repository.mu-varna.bg/handle/nls/4135","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Mutafova, Ivanka","Мутафова, Иванка"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2025-07-29T13:28:58Z","2025"]},{"key":"dc:publisher","label":"Institution","values":["Medical University of Varna"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["drug-drug interactions","adverse reaction","EGFR inhibitors","Фармакология / Pharmacology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://repository.mu-varna.bg/handle/nls/4135"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Concomitant use of several medications often increases the risk of adverse reactions and can compromise the treatment. Because of this, the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their mechanism of action, contraindications, drug interactions, and adverse reactions. On the other hand, patients also have comorbidities, which lead to the concomitant use of a large number of drugs and the intake of special foods, nutritional supplements and herbal products that patients prescribe themselves. The listed factors place the recognition of drug interactions as one of the main challenges for physicians. The main goal is to minimise adverse events related to drug interactions and to maximise clinical efficacy, leading to increased overall survival and improved quality of life. The thesis summarises the available and collected information by using online platforms for detecting drug-drug interactions and a publicly available database for reporting adverse drug reactions, which will increase knowledge in the field of drug interactions in the treatment of non-small-cell lung cancer with epidermal growth factor receptor inhibitors.","Едновременната употреба на няколко лекарства често повишава риска от нежелани реакции и може да компрометира лечението. Ето защо в клиничната практика идентифицирането и оценката на потенциални лекарствени взаимодействия има важно значение. Въвеждането на таргетната терапия доведе до нови предизвикателства. Това са лекарства, отскоро въведени в практиката и недобре познати на специалистите като механизъм на действие, противопоказания, лекарствени взаимодействия, нежелани реакции. Много често пациентите имат и други придружаващи заболявания, което води до едновременната употреба на голям брой лекарства и прием на специални храни, хранителни добавки и билкови продукти, които пациентите си предписват сами. Изброените фактори поставят разпознаването на лекарствените взаимодействия като едно от основните предизвикателства пред лекарите. Основна цел е да бъдат сведени до минимум нежеланите събития, свързани с лекарствени взаимодействия, и да се увеличи максимално клиничната ефикасност водеща до повишена обща преживяемост и подобрено качество на живот. В настоящият дисертационен труд се обобщава наличната и получена информация от използване на онлайн платформи за откриване на лекарствени взаимодействия и публично достъпни база данни за докладване на нежелани лекарствени реакции, която да обогати познанията в областта на лекарствените взаимодействия при лечението на недребноклетъчен белодробен карцином с инхибитори на рецептора на епидермалния растежен фактор."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином"]}]}],"canonical_facts":{"dc:creator":["Mutafova, Ivanka","Мутафова, Иванка"],"dc:date":["2025-07-29T13:28:58Z","2025"],"dc:description":["Concomitant use of several medications often increases the risk of adverse reactions and can compromise the treatment. Because of this, the identification and assessment of potential drug-drug interactions in clinical practice is important. The introduction of targeted therapy has led to new challenges. These drugs have been recently introduced into clinical practice and are not well-known to specialists in terms of their mechanism of action, contraindications, drug interactions, and adverse reactions. On the other hand, patients also have comorbidities, which lead to the concomitant use of a large number of drugs and the intake of special foods, nutritional supplements and herbal products that patients prescribe themselves. The listed factors place the recognition of drug interactions as one of the main challenges for physicians. The main goal is to minimise adverse events related to drug interactions and to maximise clinical efficacy, leading to increased overall survival and improved quality of life. The thesis summarises the available and collected information by using online platforms for detecting drug-drug interactions and a publicly available database for reporting adverse drug reactions, which will increase knowledge in the field of drug interactions in the treatment of non-small-cell lung cancer with epidermal growth factor receptor inhibitors.","Едновременната употреба на няколко лекарства често повишава риска от нежелани реакции и може да компрометира лечението. Ето защо в клиничната практика идентифицирането и оценката на потенциални лекарствени взаимодействия има важно значение. Въвеждането на таргетната терапия доведе до нови предизвикателства. Това са лекарства, отскоро въведени в практиката и недобре познати на специалистите като механизъм на действие, противопоказания, лекарствени взаимодействия, нежелани реакции. Много често пациентите имат и други придружаващи заболявания, което води до едновременната употреба на голям брой лекарства и прием на специални храни, хранителни добавки и билкови продукти, които пациентите си предписват сами. Изброените фактори поставят разпознаването на лекарствените взаимодействия като едно от основните предизвикателства пред лекарите. Основна цел е да бъдат сведени до минимум нежеланите събития, свързани с лекарствени взаимодействия, и да се увеличи максимално клиничната ефикасност водеща до повишена обща преживяемост и подобрено качество на живот. В настоящият дисертационен труд се обобщава наличната и получена информация от използване на онлайн платформи за откриване на лекарствени взаимодействия и публично достъпни база данни за докладване на нежелани лекарствени реакции, която да обогати познанията в областта на лекарствените взаимодействия при лечението на недребноклетъчен белодробен карцином с инхибитори на рецептора на епидермалния растежен фактор."],"dc:format":["application/pdf"],"dc:identifier":["http://repository.mu-varna.bg/handle/nls/4135"],"dc:publisher":["Medical University of Varna"],"dc:subject":["drug-drug interactions","adverse reaction","EGFR inhibitors","Фармакология / Pharmacology"],"dc:title":["Study of Potential Drug Interactions of Epidermal Growth Factor Receptor Inhibitors (EGFR inhibitors) in the Treatment of Non-Small-Cell Lung Cancer // Проучване на потенциални лекарствени взаимодействия при използване на инхибитори на рецептора на епидермалния растежен фактор (EGFR-инхибитори) при лечение на недребноклетъчен белодробен карцином"],"dc:type":["thesis"]},"updated_at":"2026-07-27T21:56:59Z"}