Pharmacological Investigation with Anethole in an Experimental Model of Obesity // Фармакологични проучвания с анетол в експериментален модел на затлъстяване

The thesis aims to investigate and summarise the pharmacological activity of monoterpene anethole administered orally in increasing doses to rats in a model of obesity induced by a high-calorie diet. For this purpose, 50 male Wistar rats, divided into 5 groups, consumed a high-calorie diet and were treated with three different doses of anethole for 10 weeks (65, 125 and 250 ml/kg). Behavioural, biochemical, histological and immunohistochemical tests were performed. For the first time in diet-induced obesity, anethole has been found to increase caloric intake, improve spatial memory, and suppress lipid peroxidation in the brain. For the first time, data were obtained on the effects of anethole on programmed cell death in retroperitoneal adipose tissue and liver in rats with an experimental model of diet-induced obesity.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2024

Authors dc:creator

• Rafailova, Elis
• Рафаилова, Елис

• anethole
• obesity
• high-calorie diet
• diet-induced obesity
• cell death
• Фармакология / Pharmacology

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/3878

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/3878