New Aspects in the Pharmaceutical Analysis of Quinine and Some of Its Oxidation Products // Нови аспекти във фармацевтичния анализ на Quinine и някои негови продукти на окисление
The thesis explores various aspects of the qualitative analysis of the alkaloids quinine and quinotoxine – representatives of the general alkaloid set of cortex Chinae. Quinine is a pharmacopoeial representative currently used in the therapy of malaria, particularly in cases of its cerebral form. Quinotoxine has been used for approximately a decade in medical practice as a cerebral vasodilator. Numerous derivatives with radically different behaviour and activity have been obtained from both alkaloids. Therefore, every single aspect of the analysis of these alkaloids is significant and contributes to the general knowledge of this class of bioorganic compounds. Additionally, the qualitative analysis is an element of the general identification analysis of each pharmacopoeial and pharmacologically significant representative. In this regard, the methods of qualitative alkaloid analysis are the main topic of the present work. Although adapted, the analytical methods presented here have original features and innovations. In some, different interdisciplinary motives are combined – those of physics, photochemistry, and fine organic synthesis. Not every one of the presented methods is reflected in the scientific literature, but they are still considered valid within the context of additional research that goes beyond the generally accepted framework for a thesis.
quinine, quinotoxine, malaria, cerebral vasodilator, Химия / Chemistry
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