Complex Evaluation of the Effectiveness of Biological Therapy in Patients with Active Ulcerative Colitis // Комплексна оценка на ефективността от биологична терапия при болни с активен язвен колит

Inflammatory bowel diseases (IBD), namely ulcerative colitis (UC) and Crohn's disease (CD), are chronic immune-mediated conditions with a high incidence in developed countries and a rapidly increasing incidence in highly industrialized countries. The pathogenesis of UC is complex and still unclear. The choice of therapy is determined by the course, extent, severity of disease, lack of response to treatment and safety. The main goals of therapy for UC are to induce and maintain clinical and endoscopic remission of the disease, reduce the risk of complications and improve quality of life. The therapeutic goals in IBD have changed with the introduction of biological therapy. These medications have demonstrated that control of mucosal inflammation is possible. Healing of the mucosa is accompanied by fewer complications and better patient parameters achieved. At present, symptom control, which is one of the primary treatment goals, appears insufficient. Today, the main task is mucosal healing. Achieving lasting remission is a major goal and a challenge that finds an answer and a solution in modern biological treatment. This determined our motivation for conducting this clinical observation on the efficacy and safety of biological therapy of active ulcerative colitis.

Grantor dc:publisher

Medical University of Varna

Year dc:date

2023

Authors dc:creator

• Petrova, Asiyana
• Петрова, Асияна

• ulcerative colitis
• inflammatory bowel disease
• Crohn's disease
• biological therapy
• mucosa
• Гастроентерология / Gastroenterology

Repository record dc:identifier

http://repository.mu-varna.bg/handle/nls/3459

OAI identifier oai:identifier

oai:repository.mu-varna.bg:nls/3459