{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/37955"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/37955","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse","abstract":"Mouse models lack affordable genomic technologies slowing the identification of candidate variants contributing to complex phenotypes. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution platform permitting genomic diversity assessment. Using a validated list of >500,000 single nucleotide polymorphisms (SNPs), we applied the first comprehensive analysis of SNP differences to detect genetic distance across 362 Mus musculus samples. Genetic distance measured between distantly and closely related mice correlates with known phylogeny and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic mosaicism. Genotype differences detected within a mouse are a complex mixture of technical errors and biological differences. Detailed reconstruction experiments are therefore required to determine array sensitivity at detecting true biological variants. The MDGA shows promise for analyzing mutation accumulation with development, aging, environmental mutagenesis and diseases such as cancers.","abstract_html":"Mouse models lack affordable genomic technologies slowing the identification of candidate variants contributing to complex phenotypes. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution platform permitting genomic diversity assessment. Using a validated list of >500,000 single nucleotide polymorphisms (SNPs), we applied the first comprehensive analysis of SNP differences to detect genetic distance across 362 Mus musculus samples. Genetic distance measured between distantly and closely related mice correlates with known phylogeny and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic mosaicism. Genotype differences detected within a mouse are a complex mixture of technical errors and biological differences. Detailed reconstruction experiments are therefore required to determine array sensitivity at detecting true biological variants. The MDGA shows promise for analyzing mutation accumulation with development, aging, environmental mutagenesis and diseases such as cancers.","abstract_has_math":false,"creators":["Eitutis, Susan T"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Biology","degree_department":null,"school":null,"contributors":[],"advisors":["Kathleen Hill"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-07-23","date_published":"2013-07-23","updated_at":"2026-07-27T21:55:56Z","subjects":["Single nucleotide polymorphism","Genotyping","Genomic","Mutation","Genetic Distance","Genetic Background","Mus musculus","Mouse Diversity Genotyping Array","genetic variation","somatic mosaicism"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/37955","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Kathleen Hill"]},{"key":"dc:creator","label":"Author","values":["Eitutis, Susan T"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:45:24Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:45:24Z"]},{"key":"dc:date.issued","label":"Date","values":["2013-07-23"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Biology"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Single nucleotide polymorphism","Genotyping","Genomic","Mutation","Genetic Distance","Genetic Background","Mus musculus","Mouse Diversity Genotyping Array","genetic variation","somatic mosaicism"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/37955"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Mouse models lack affordable genomic technologies slowing the identification of candidate variants contributing to complex phenotypes. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution platform permitting genomic diversity assessment. Using a validated list of >500,000 single nucleotide polymorphisms (SNPs), we applied the first comprehensive analysis of SNP differences to detect genetic distance across 362 Mus musculus samples. Genetic distance measured between distantly and closely related mice correlates with known phylogeny and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic mosaicism. Genotype differences detected within a mouse are a complex mixture of technical errors and biological differences. Detailed reconstruction experiments are therefore required to determine array sensitivity at detecting true biological variants. The MDGA shows promise for analyzing mutation accumulation with development, aging, environmental mutagenesis and diseases such as cancers."]},{"key":"dc:title","label":"Title","values":["Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse"]}]}],"canonical_facts":{"dc:contributor.advisor":["Kathleen Hill"],"dc:creator":["Eitutis, Susan T"],"dc:date.accessioned":["2025-07-10T21:45:24Z"],"dc:date.available":["2025-07-10T21:45:24Z"],"dc:date.issued":["2013-07-23"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Mouse models lack affordable genomic technologies slowing the identification of candidate variants contributing to complex phenotypes. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution platform permitting genomic diversity assessment. Using a validated list of >500,000 single nucleotide polymorphisms (SNPs), we applied the first comprehensive analysis of SNP differences to detect genetic distance across 362 Mus musculus samples. Genetic distance measured between distantly and closely related mice correlates with known phylogeny and genealogy. Variation detected between C57BL/6J mice is consistent with previous reports of variants within this strain. Putative genetic variation detected between and within tissues indicates somatic mosaicism. Genotype differences detected within a mouse are a complex mixture of technical errors and biological differences. Detailed reconstruction experiments are therefore required to determine array sensitivity at detecting true biological variants. The MDGA shows promise for analyzing mutation accumulation with development, aging, environmental mutagenesis and diseases such as cancers."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/37955"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Single nucleotide polymorphism","Genotyping","Genomic","Mutation","Genetic Distance","Genetic Background","Mus musculus","Mouse Diversity Genotyping Array","genetic variation","somatic mosaicism"],"dc:title":["Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse"],"dc:type":["thesis"],"thesis:degree_discipline":["Biology"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:55:56Z"}