{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/37847"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/37847","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"The Effect of Selective Hypothermia on Stroke Volume","abstract":"Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was 26.5C. Mean time from start of perfusion to moderate hypothermia (< 30 C) was 25.4 minutes. Mean stroke volumes were reduced by 38.4-44.2% in the hypothermia group (p=0.292). Selective moderate hypothermia can be rapidly induced using endovascular technology. A promising reduction in stroke volumes is seen. Further study is warranted.","abstract_html":"Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was 26.5C. Mean time from start of perfusion to moderate hypothermia (&lt; 30 C) was 25.4 minutes. Mean stroke volumes were reduced by 38.4-44.2% in the hypothermia group (p=0.292). Selective moderate hypothermia can be rapidly induced using endovascular technology. A promising reduction in stroke volumes is seen. Further study is warranted.","abstract_has_math":false,"creators":["Mattingly, Thomas K"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["Stephen Lownie, MD"],"committee_chairs":[],"committee_members":[],"year":2013,"date_issued":"2013-05-14","date_published":"2013-05-14","updated_at":"2026-07-27T21:56:14Z","subjects":["selective hypothermia","focal cerebral ischemia","stroke","endovascular","porcinelar"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/37847","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Stephen Lownie, MD"]},{"key":"dc:creator","label":"Author","values":["Mattingly, Thomas K"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:43:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:43:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2013-05-14"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["selective hypothermia","focal cerebral ischemia","stroke","endovascular","porcinelar"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/37847"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was 26.5C. Mean time from start of perfusion to moderate hypothermia (< 30 C) was 25.4 minutes. Mean stroke volumes were reduced by 38.4-44.2% in the hypothermia group (p=0.292). Selective moderate hypothermia can be rapidly induced using endovascular technology. A promising reduction in stroke volumes is seen. Further study is warranted."]},{"key":"dc:title","label":"Title","values":["The Effect of Selective Hypothermia on Stroke Volume"]}]}],"canonical_facts":{"dc:contributor.advisor":["Stephen Lownie, MD"],"dc:creator":["Mattingly, Thomas K"],"dc:date.accessioned":["2025-07-10T21:43:08Z"],"dc:date.available":["2025-07-10T21:43:08Z"],"dc:date.issued":["2013-05-14"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Hypothermia is a well-established neuroprotectant. Selective hypothermia to the ischemic area may eliminate side effects while improving induction time. We studied the effect of selective hypothermia on stroke volumes in adult domestic swine. Under general anesthesia, one MCA was occluded transcranially for 3 hours followed by 3 hours of reperfusion. In half the animals, hypothermia was induced during reperfusion via a dual-lumen balloon occlusion catheter placed in the carotid ipsilateral to the ischemic region. Following reperfusion, the animals were sacrificed. Brain MRI and histology were evaluated blinded to the intervention. In a series of animals, the mean temperature achieved was 26.5C. Mean time from start of perfusion to moderate hypothermia (< 30 C) was 25.4 minutes. Mean stroke volumes were reduced by 38.4-44.2% in the hypothermia group (p=0.292). Selective moderate hypothermia can be rapidly induced using endovascular technology. A promising reduction in stroke volumes is seen. Further study is warranted."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/37847"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["selective hypothermia","focal cerebral ischemia","stroke","endovascular","porcinelar"],"dc:title":["The Effect of Selective Hypothermia on Stroke Volume"],"dc:type":["thesis"],"thesis:degree_discipline":["Medical Biophysics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:14Z"}