{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/37052"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/37052","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Characterization of Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy (DMD) Using Echocardiography, DCE-CT, and PET-FDG","abstract":"Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disease that is the result of a loss of functional dystrophin, which causes cardiomyocyte fibrosis and death, leading to cardiomyopathy. In this thesis, I have utilized dynamic contrast-enhanced computed tomography (DCE-CT), positron emission tomography-fluorodeoxyglucose (PET-FDG), echocardiography, and traditional histology to longitudinally assess disease progression and degree of cardiomyopathy in a murine model of DMD (mdx:utrn-/-). No significant changes were observed in the blood flow, blood volume, or cardiac volume measured via DCE-CT, nor in standard uptake value (SUV) of glucose as measured by PET-FDG in the left myocardium between and within the two study groups (of mdx:utrn -/- mice and healthy wild-type mice) over time. Our pilot echocardiography study and histological results show possible morphological/architectural and functional changes in affected myocardia of mdx:utrn-/- mice. These findings may provide us with an avenue to longitudinally characterize the progression of cardiomyopathy in the murine model of DMD, mdx:utrn -/- , in addition to providing a potential baseline for a comparison with future therapeutics.","abstract_html":"Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disease that is the result of a loss of functional dystrophin, which causes cardiomyocyte fibrosis and death, leading to cardiomyopathy. In this thesis, I have utilized dynamic contrast-enhanced computed tomography (DCE-CT), positron emission tomography-fluorodeoxyglucose (PET-FDG), echocardiography, and traditional histology to longitudinally assess disease progression and degree of cardiomyopathy in a murine model of DMD (mdx:utrn-/-). No significant changes were observed in the blood flow, blood volume, or cardiac volume measured via DCE-CT, nor in standard uptake value (SUV) of glucose as measured by PET-FDG in the left myocardium between and within the two study groups (of mdx:utrn -/- mice and healthy wild-type mice) over time. Our pilot echocardiography study and histological results show possible morphological/architectural and functional changes in affected myocardia of mdx:utrn-/- mice. These findings may provide us with an avenue to longitudinally characterize the progression of cardiomyopathy in the murine model of DMD, mdx:utrn -/- , in addition to providing a potential baseline for a comparison with future therapeutics.","abstract_has_math":false,"creators":["Moazami, Seyed Hamed"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["Lisa Hoffman"],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012-11-20","date_published":"2012-11-20","updated_at":"2026-07-27T21:56:01Z","subjects":["Duchenne Muscular Dystrophy","Cardiomyopathy","Dynamic contrast enhanced computed tomography","Positron emission tomography","Echocardiography","Mdx:utrn-/-"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/37052","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Lisa Hoffman"]},{"key":"dc:creator","label":"Author","values":["Moazami, Seyed Hamed"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:29:13Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:29:13Z"]},{"key":"dc:date.issued","label":"Date","values":["2012-11-20"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Duchenne Muscular Dystrophy","Cardiomyopathy","Dynamic contrast enhanced computed tomography","Positron emission tomography","Echocardiography","Mdx:utrn-/-"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/37052"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disease that is the result of a loss of functional dystrophin, which causes cardiomyocyte fibrosis and death, leading to cardiomyopathy. In this thesis, I have utilized dynamic contrast-enhanced computed tomography (DCE-CT), positron emission tomography-fluorodeoxyglucose (PET-FDG), echocardiography, and traditional histology to longitudinally assess disease progression and degree of cardiomyopathy in a murine model of DMD (mdx:utrn-/-). No significant changes were observed in the blood flow, blood volume, or cardiac volume measured via DCE-CT, nor in standard uptake value (SUV) of glucose as measured by PET-FDG in the left myocardium between and within the two study groups (of mdx:utrn -/- mice and healthy wild-type mice) over time. Our pilot echocardiography study and histological results show possible morphological/architectural and functional changes in affected myocardia of mdx:utrn-/- mice. These findings may provide us with an avenue to longitudinally characterize the progression of cardiomyopathy in the murine model of DMD, mdx:utrn -/- , in addition to providing a potential baseline for a comparison with future therapeutics."]},{"key":"dc:title","label":"Title","values":["Characterization of Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy (DMD) Using Echocardiography, DCE-CT, and PET-FDG"]}]}],"canonical_facts":{"dc:contributor.advisor":["Lisa Hoffman"],"dc:creator":["Moazami, Seyed Hamed"],"dc:date.accessioned":["2025-07-10T21:29:13Z"],"dc:date.available":["2025-07-10T21:29:13Z"],"dc:date.issued":["2012-11-20"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Duchenne muscular dystrophy (DMD) is an X-linked recessive neuromuscular disease that is the result of a loss of functional dystrophin, which causes cardiomyocyte fibrosis and death, leading to cardiomyopathy. In this thesis, I have utilized dynamic contrast-enhanced computed tomography (DCE-CT), positron emission tomography-fluorodeoxyglucose (PET-FDG), echocardiography, and traditional histology to longitudinally assess disease progression and degree of cardiomyopathy in a murine model of DMD (mdx:utrn-/-). No significant changes were observed in the blood flow, blood volume, or cardiac volume measured via DCE-CT, nor in standard uptake value (SUV) of glucose as measured by PET-FDG in the left myocardium between and within the two study groups (of mdx:utrn -/- mice and healthy wild-type mice) over time. Our pilot echocardiography study and histological results show possible morphological/architectural and functional changes in affected myocardia of mdx:utrn-/- mice. These findings may provide us with an avenue to longitudinally characterize the progression of cardiomyopathy in the murine model of DMD, mdx:utrn -/- , in addition to providing a potential baseline for a comparison with future therapeutics."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/37052"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Duchenne Muscular Dystrophy","Cardiomyopathy","Dynamic contrast enhanced computed tomography","Positron emission tomography","Echocardiography","Mdx:utrn-/-"],"dc:title":["Characterization of Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy (DMD) Using Echocardiography, DCE-CT, and PET-FDG"],"dc:type":["thesis"],"thesis:degree_discipline":["Medical Biophysics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:01Z"}