{"id":{"repo_id":"uwo","oai_identifier":"oai:uwo.scholaris.ca:20.500.14721/36971"},"canonical_url":"https://search.dev.ndltd.org/etd/uwo/oai:uwo.scholaris.ca:20.500.14721/36971","repository":{"repo_id":"uwo","name":"Western University","base_url":"https://uwo.scholaris.ca/server/oai/request"},"display":{"title":"Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity","abstract":"Hemiplegic cerebral palsy is characterized by unilateral upper limb impairment and patients often compensate by performing most tasks with their unaffected arm. Constraint-induced movement therapy (CIMT) directly combats this learned non-use by casting the unaffected arm and forcing the patient to repetitively practice skills with the hemiplegic limb. Subjects with hemiplegic cerebral palsy were recruited from Holland Bloorview Kids Rehabilitation Hospital, Thames Valley Children’s Centre and McMaster Children’s Hospital. MRI acquisitions and clinical evaluations were collected at baseline, 1 and 6-months later. The case group participated in a CIMT camp after baseline evaluations and was compared to an untreated control group. Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) acquisitions quantify global network organization and neural integrity, respectively, and found alterations in multiple resting state network connectivity patterns and significantly different fractional anisotropy and mean diffusivity in the affected corticospinal tract. Asymmetric baseline sensorimotor network organization was predictive of a positive and continuous functional response to CIMT. Clinically correlated network reorganization provides further evidence of neuroplastic mechanisms related to CIMT.","abstract_html":"Hemiplegic cerebral palsy is characterized by unilateral upper limb impairment and patients often compensate by performing most tasks with their unaffected arm. Constraint-induced movement therapy (CIMT) directly combats this learned non-use by casting the unaffected arm and forcing the patient to repetitively practice skills with the hemiplegic limb. Subjects with hemiplegic cerebral palsy were recruited from Holland Bloorview Kids Rehabilitation Hospital, Thames Valley Children’s Centre and McMaster Children’s Hospital. MRI acquisitions and clinical evaluations were collected at baseline, 1 and 6-months later. The case group participated in a CIMT camp after baseline evaluations and was compared to an untreated control group. Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) acquisitions quantify global network organization and neural integrity, respectively, and found alterations in multiple resting state network connectivity patterns and significantly different fractional anisotropy and mean diffusivity in the affected corticospinal tract. Asymmetric baseline sensorimotor network organization was predictive of a positive and continuous functional response to CIMT. Clinically correlated network reorganization provides further evidence of neuroplastic mechanisms related to CIMT.","abstract_has_math":false,"creators":["Manning, Kathryn Y"],"institution":"The University of Western Ontario","degree_name":"M Sc","degree_level":null,"degree_discipline":"Medical Biophysics","degree_department":null,"school":null,"contributors":[],"advisors":["Ravi Menon"],"committee_chairs":[],"committee_members":[],"year":2014,"date_issued":"2014-03-21","date_published":"2014-03-21","updated_at":"2026-07-27T21:56:16Z","subjects":["Functional magnetic resonance imaging","diffusion tensor imaging","resting state network","hemiplegic cerebral palsy","constraint-induced movement therapy","neuroplasticity"],"languages":["en_ca"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/20.500.14721/36971","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Ravi Menon"]},{"key":"dc:creator","label":"Author","values":["Manning, Kathryn Y"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2025-07-10T21:28:02Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2025-07-10T21:28:02Z"]},{"key":"dc:date.issued","label":"Date","values":["2014-03-21"]},{"key":"dc:publisher","label":"Institution","values":["The University of Western Ontario"]},{"key":"dc:type","label":"Dc Type","values":["thesis"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medical Biophysics"]},{"key":"thesis:degree_name","label":"Degree Name","values":["M Sc"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Functional magnetic resonance imaging","diffusion tensor imaging","resting state network","hemiplegic cerebral palsy","constraint-induced movement therapy","neuroplasticity"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_ca"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/20.500.14721/36971"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."]},{"key":"dc:description.abstract","label":"Abstract","values":["Hemiplegic cerebral palsy is characterized by unilateral upper limb impairment and patients often compensate by performing most tasks with their unaffected arm. Constraint-induced movement therapy (CIMT) directly combats this learned non-use by casting the unaffected arm and forcing the patient to repetitively practice skills with the hemiplegic limb. Subjects with hemiplegic cerebral palsy were recruited from Holland Bloorview Kids Rehabilitation Hospital, Thames Valley Children’s Centre and McMaster Children’s Hospital. MRI acquisitions and clinical evaluations were collected at baseline, 1 and 6-months later. The case group participated in a CIMT camp after baseline evaluations and was compared to an untreated control group. Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) acquisitions quantify global network organization and neural integrity, respectively, and found alterations in multiple resting state network connectivity patterns and significantly different fractional anisotropy and mean diffusivity in the affected corticospinal tract. Asymmetric baseline sensorimotor network organization was predictive of a positive and continuous functional response to CIMT. Clinically correlated network reorganization provides further evidence of neuroplastic mechanisms related to CIMT."]},{"key":"dc:title","label":"Title","values":["Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity"]}]}],"canonical_facts":{"dc:contributor.advisor":["Ravi Menon"],"dc:creator":["Manning, Kathryn Y"],"dc:date.accessioned":["2025-07-10T21:28:02Z"],"dc:date.available":["2025-07-10T21:28:02Z"],"dc:date.issued":["2014-03-21"],"dc:description":["The thesis cover page in the PDF document includes references to Western University’s previous institutional repository platform, known as Scholarship@Western, and links to that platform (beginning with ir.lib.uwo.ca). In citing or referring to this thesis, use the DOI or handle from this page instead. Sample citation: Author name, \"Thesis title.\" (Year). Western University Open Repository. https://doi.org/10.71858/123456."],"dc:description.abstract":["Hemiplegic cerebral palsy is characterized by unilateral upper limb impairment and patients often compensate by performing most tasks with their unaffected arm. Constraint-induced movement therapy (CIMT) directly combats this learned non-use by casting the unaffected arm and forcing the patient to repetitively practice skills with the hemiplegic limb. Subjects with hemiplegic cerebral palsy were recruited from Holland Bloorview Kids Rehabilitation Hospital, Thames Valley Children’s Centre and McMaster Children’s Hospital. MRI acquisitions and clinical evaluations were collected at baseline, 1 and 6-months later. The case group participated in a CIMT camp after baseline evaluations and was compared to an untreated control group. Resting state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) acquisitions quantify global network organization and neural integrity, respectively, and found alterations in multiple resting state network connectivity patterns and significantly different fractional anisotropy and mean diffusivity in the affected corticospinal tract. Asymmetric baseline sensorimotor network organization was predictive of a positive and continuous functional response to CIMT. Clinically correlated network reorganization provides further evidence of neuroplastic mechanisms related to CIMT."],"dc:identifier.uri":["https://hdl.handle.net/20.500.14721/36971"],"dc:language.iso":["en_ca"],"dc:publisher":["The University of Western Ontario"],"dc:subject":["Functional magnetic resonance imaging","diffusion tensor imaging","resting state network","hemiplegic cerebral palsy","constraint-induced movement therapy","neuroplasticity"],"dc:title":["Resting State Functional Magnetic Resonance and Diffusion Tensor Imaging of Hemiplegic Cerebral Palsy Patients Treated with Constraint-Induced Movement Therapy: Predictors and Clinically Correlated Evidence of Neuroplasticity"],"dc:type":["thesis"],"thesis:degree_discipline":["Medical Biophysics"],"thesis:degree_name":["M Sc"]},"updated_at":"2026-07-27T21:56:16Z"}